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公开(公告)号：US11446354B2
公开(公告)日：2022-09-20
申请号：US17190013
申请日：2021-03-02
申请人： Hexima Limited
IPC分类号： A61K38/16 , A61K45/06 , A61K9/00 , A61K31/454 , A61K31/4174 , A61K31/137 , A61K31/496 , A61K31/69 , A61K31/4418 , A61K31/4196 , A61K31/5375
摘要： The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.
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公开(公告)号：US09540423B2
公开(公告)日：2017-01-10
申请号：US14352360
申请日：2012-10-19
发明人： Mark Darren Hulett , Fung Tso Lay
IPC分类号： C07K14/415 , A61K38/16 , A61K38/00
CPC分类号： C07K14/415 , A61K38/00 , A61K38/168 , C07K2319/00
摘要： The present invention relates to compositions and methods for preventing or treating proliferative diseases. In particular, the present invention relates to the use of compositions derived or derivable from plants, such as plant defensins, particularly in methods for the prevention or treatment of proliferative diseases such as cancer. The present invention also relates to associated uses, systems and kits.
摘要翻译： 本发明涉及预防或治疗增殖性疾病的组合物和方法。 特别地，本发明涉及衍生或衍生自植物的组合物如植物防御素的用途，特别是用于预防或治疗增殖性疾病例如癌症的方法。 本发明还涉及相关的用途，系统和试剂盒。
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公开(公告)号：US20150067917A1
公开(公告)日：2015-03-05
申请号：US14535111
申请日：2014-11-06
申请人： HEXIMA LIMITED
发明人： Robyn Louise HEATH , Marilyn Anne ANDERSON , Nicole Louise VAN DER WEERDEN , James Anthony MCKENNA , Simon POON
CPC分类号： C12N15/8282 , A01N37/46 , A01N65/00 , A01N65/385 , C12N15/8201 , C12N15/8279 , A01N2300/00
摘要： Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.
摘要翻译： 提供了一种保护植物免受害虫侵袭的系统，包括病原体如真菌。 特别地，植物防御素与蛋白酶抑制剂一起提供，保护植物免受有害生物侵袭或降低攻击的严重性。
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公开(公告)号：US20130269059A1
公开(公告)日：2013-10-10
申请号：US13837472
申请日：2013-03-15
申请人： Hexima Limited
发明人： Robyn Louise HEATH , Marilyn Anne Anderson , Nicole Louise van der Weerden , James Anthony McKenna , Simon Poon
IPC分类号： C12N15/82
CPC分类号： C12N15/8282 , A01N65/00 , A01N65/385 , C07K14/415 , C07K14/8139 , C12N15/8279 , A01N37/46 , A01N2300/00
摘要： Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.
摘要翻译： 提供了一种保护植物免受害虫侵袭的系统，包括病原体如真菌。 特别地，植物防御素与蛋白酶抑制剂一起提供，保护植物免受有害生物侵袭或降低攻击的严重性。
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公开(公告)号：US20130267459A1
公开(公告)日：2013-10-10
申请号：US13839745
申请日：2013-03-15
申请人： HEXIMA LIMITED
发明人： Robyn Louis Heath , Marilyn Anne Anderson , Nicole Louise van der Weerden , James Anthony McKenna , Simon Poon
IPC分类号： A61K38/56
CPC分类号： A61K38/56 , A01N65/00 , A01N65/385 , C07K14/415 , C07K14/8139 , C12N15/8279 , C12N15/8282 , A01N37/46 , A01N2300/00
摘要： Provided is a system for protecting plants from attack by pests, including pathogens such as fungi. Specifically, a plant defensin is provided in conjunction with a protease inhibitor protects a plant from pest attack or reduces severity of an attack.
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公开(公告)号：US20230077847A1
公开(公告)日：2023-03-16
申请号：US17973124
申请日：2022-10-25
发明人： Lu LIU , Amy LUM , Azalea S. ONG , Eric SCHEPERS , Ingrid UDRANSZKY , Xiaohong ZHONG
IPC分类号： C12N15/82
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
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公开(公告)号：US10973874B2
公开(公告)日：2021-04-13
申请号：US15494400
申请日：2017-04-21
申请人： Hexima Limited
IPC分类号： A61K38/16 , A61K45/06 , A61K9/00 , A61K31/454 , A61K31/4174 , A61K31/137 , A61K31/496 , A61K31/69 , A61K31/4418 , A61K31/4196 , A61K31/5375
摘要： The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.
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公开(公告)号：US20190327965A1
公开(公告)日：2019-10-31
申请号：US16357200
申请日：2019-03-18
申请人： Hexima Limited
IPC分类号： A01N37/46 , A61Q19/10 , A61Q5/02 , A61Q17/00 , A61K8/42 , C07K14/415 , A61K38/16 , A61K38/17 , A01N63/02 , C12N15/82 , A01N65/38 , A61K38/01
摘要： Pathogen infection and infestation can be controlled in humans, animals and plants by contacting the pathogen with an effective amount of a combination of a plant defensin or a functional natural or synthetic derivative or variant thereof and a non-defensin peptide. Pathogen contamination in environmental locales can also be controlled. The combination of the defensin and peptide are synergistic compared to the use of each alone at the same individual dose as used in the combination. The combinations can be presented in agents and natural and synthetic formulations and extracts.
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公开(公告)号：US09713632B2
公开(公告)日：2017-07-25
申请号：US14726400
申请日：2015-05-29
申请人： Hexima Limited
CPC分类号： A61K38/168 , A61K9/0014 , A61K31/137 , A61K31/4174 , A61K31/4196 , A61K31/4418 , A61K31/454 , A61K31/496 , A61K31/5375 , A61K31/69 , A61K45/06 , A61K2300/00
摘要： The present disclosure relates to the control of fungal infection of horn-like envelopes covering dorsal and terminal phalanges in humans and animals and related cerebral protrusions in animals as well as keratin comprising material on surfaces of humans and animals. Agents and natural and synthetic formulations and extracts useful for the control of fungal infection of these envelopes and related protrusions and keratin comprising material are also encompassed by the subject disclosure. In an embodiment, the present disclosure teaches the treatment of fungal infection of nails and in particular onychomycosis in humans.
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公开(公告)号：US20150283204A1
公开(公告)日：2015-10-08
申请号：US14646579
申请日：2013-11-22
申请人： HEXIMA LIMITED
IPC分类号： A61K38/16 , A61K45/06 , A01N65/38 , A01N65/08 , C12N15/82 , A01N65/44 , A01N65/12 , A01N65/28 , A01N65/40 , C07K14/415 , A61K9/00 , A01N65/20
CPC分类号： A61K38/168 , A01N37/46 , A01N65/00 , A01N65/08 , A01N65/12 , A01N65/20 , A01N65/28 , A01N65/38 , A01N65/385 , A01N65/40 , A01N65/44 , A61K9/0014 , A61K45/06 , C07K14/415 , C12N15/8279 , C12N15/8282 , C12N15/8286
摘要： The present disclosure teaches the protection of plants and human and non-human subjects from pathogens. The present disclosure enables a multivalent approach to inhibiting pathogen infection in plant and human and non-human animal subjects and to ameliorate damage to susceptible subjects.
摘要翻译： 本公开教导了植物和人和非人类受试者从病原体的保护。 本公开使得多价方法能够抑制植物和人和非人动物受试者中的病原体感染并改善对易感受试者的损伤。
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