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公开(公告)号：US08703187B2
公开(公告)日：2014-04-22
申请号：US12148987
申请日：2008-04-24
IPC分类号： A61K9/20
CPC分类号： A61K9/2077 , A61K9/2009 , A61K9/2095 , A61K31/59 , A61K33/10 , A61K2300/00
摘要： New dosage forms of vitamin D and calcium carbonate having improved content uniformity are described. The improvements are realized through modifications to the formulation, the raw material specifications, and the process of manufacture.
摘要翻译： 描述了具有改善的含量均匀性的维生素D和碳酸钙的新剂型。 通过对配方，原材料规格和制造过程进行修改来实现改进。
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2.发明授权公开(公告)号：US08580302B2
公开(公告)日：2013-11-12
申请号：US11070995
申请日：2005-03-03
CPC分类号： A61K9/284 , A61K9/2846 , A61K9/2886 , A61K9/4891 , A61K31/196
摘要： The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) 1:2, poly(methacrylic acid, methyl methacrylate) 1:1, and mixtures thereof; and c. an outer coating layer comprising an enteric polymer or film coating material; wherein the inner coating layer is not the same as the outer coating layer; wherein if the inner coating layer is poly(methacrylic acid, methyl methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, methyl methacrylate) 1:2 or is not a mixture of poly(methacrylic acid, methyl methacrylate) 1:1 and poly(methacrylic acid, methyl methacrylate) 1:2; and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent. This invention further relates to a method of maintaining the desired site of delivery of a therapeutic agent in the gastrointestinal tract by administering the above compositions to a human or lower animal.
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公开(公告)号：US20090022792A1
公开(公告)日：2009-01-22
申请号：US12148987
申请日：2008-04-24
CPC分类号： A61K9/2077 , A61K9/2009 , A61K9/2095 , A61K31/59 , A61K33/10 , A61K2300/00
摘要： New dosage forms of vitamin D and calcium carbonate having improved content uniformity are described. The improvements are realized through modifications to the formulation, the raw material specifications, and the process of manufacture.
摘要翻译： 描述了具有改善的含量均匀性的维生素D和碳酸钙的新剂型。 通过对配方，原材料规格和制造过程进行修改来实现改进。
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4.发明授权公开(公告)号：US06893662B2
公开(公告)日：2005-05-17
申请号：US09996555
申请日：2001-11-15
CPC分类号： A61K9/284 , A61K9/2846 , A61K9/2886 , A61K9/4891 , A61K31/196
摘要： The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent; b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) 1:2, poly(methacrylic acid, methyl methacrylate) 1:1, and mixtures thereof; and c. an outer coating layer comprising an enteric polymer or film coating material; wherein the inner coating layer is not the same as the outer coating layer; wherein if the inner coating layer is poly(methacrylic acid, methyl methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, methyl methacrylate) 1:2 or is not a mixture of poly(methacrylic acid, methyl methacrylate) 1:1 and poly(methacrylic acid, methyl methacrylate) 1:2; and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent. This invention further relates to a method of maintaining the desired site of delivery of a therapeutic agent in the gastrointestinal tract by administering the above compositions to a human or lower animal.
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