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公开(公告)号：US07524509B2
公开(公告)日：2009-04-28
申请号：US10094424
申请日：2002-03-11
IPC分类号： A16K39/02 , A16K39/095 , A16K39/116 , A16K39/385 , A16K47/00 , A16K45/00
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/36 , A61K39/39 , A61K2039/543 , A61K2039/55516 , A61K2039/55572 , A61K2039/70 , C12N2760/16134 , C12N2760/16151
摘要： An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols.
摘要翻译： 由与细菌脂糖复合的细菌外膜蛋白质蛋白质组成的辅助复合物被制备成在各种条件下含有组分。 可以用抗原物质配制复合物以形成免疫原性组合物，疫苗和免疫治疗剂。 诱导的免疫应答包括保护性抗体和/或1型细胞因子用于各种方案。
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公开(公告)号：US20090252762A1
公开(公告)日：2009-10-08
申请号：US12414497
申请日：2009-03-30
CPC分类号： C12N7/00 , A61K39/12 , A61K39/145 , A61K39/36 , A61K39/39 , A61K2039/543 , A61K2039/55516 , A61K2039/55572 , A61K2039/70 , C12N2760/16134 , C12N2760/16151
摘要： An adjuvant complex composed of bacterial outer membrane protein proteosomes complexed to bacterial liposaccharide is prepared to contain the component parts under a variety of conditions. The complex can be formulated with antigenic material to form immunogenic compositions, vaccines and immunotherapeutics. An induced immune response includes protective antibodies and/or type 1 cytokines is shown for a variety of protocols.
摘要翻译： 由与细菌脂糖复合的细菌外膜蛋白质蛋白质组成的辅助复合物被制备成在各种条件下含有组分。 可以用抗原物质配制复合物以形成免疫原性组合物，疫苗和免疫治疗剂。 诱导的免疫应答包括保护性抗体和/或1型细胞因子用于各种方案。
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公开(公告)号：US07399840B2
公开(公告)日：2008-07-15
申请号：US10771737
申请日：2004-02-03
申请人： David S. Burt , David H. Jones , George H. Lowell , Gregory L. White , Kirkor Torossian , Louis F. Fries, III , Martin Plante
发明人： David S. Burt , David H. Jones , George H. Lowell , Gregory L. White , Kirkor Torossian , Louis F. Fries, III , Martin Plante
IPC分类号： A23J1/00
CPC分类号： A61K39/39 , A61K39/12 , A61K39/145 , A61K2039/5252 , A61K2039/543 , A61K2039/55516 , A61K2039/55555 , A61K2039/70 , C12N2760/16134 , C12N2760/16234
摘要： Improved forms of vaccines which comprise proteosomes and protein antigens are described. Vaccines which contain influenza HA as the antigen are used for illustration as to demonstrate efficacy. Improvements in the preparation of the vaccines themselves and the proteosome component are also included.
摘要翻译： 描述了包含蛋白质体和蛋白质抗原的改进形式的疫苗。 含有流感HA作为抗原的疫苗用于说明以证明疗效。 还包括疫苗本身和蛋白质组分的制备的改进。
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4.发明授权Phosphate prodrugs of a farnesyl dibenzodiazepinone, processes for their production and their use as pharmaceuticals 失效法呢基二苯并二氮杂酮的磷酸酯前药，其制备方法及其作为药物的用途公开(公告)号：US07384935B2
公开(公告)日：2008-06-10
申请号：US11527581
申请日：2006-09-27
申请人： Mustapha Aouidate , James B. McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun H. Banskota , Maxime Ranger , Gregory L. White
发明人： Mustapha Aouidate , James B. McAlpine , Faustinus Yeboah , Ashraf Ibrahim , Arjun H. Banskota , Maxime Ranger , Gregory L. White
IPC分类号： C07D243/10 , A61K31/551 , A61P35/00
CPC分类号： C07D243/10 , C07F9/5535
摘要： This invention relates to phosphate prodrugs of a farnesylated dibenzodiazepinone, to processes of their manufacture, to pharmaceutical compositions comprising the prodrugs, and to their use in the treatment of neoplasms.
摘要翻译： 本发明涉及法呢基化二苯并二氮杂酮的磷酸酯前药，其制备方法，包含前药的药物组合物及其在治疗赘生物中的用途。
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