公开(公告)号：US06218362B1

公开(公告)日：2001-04-17

申请号：US08924952

申请日：1997-09-08

申请人： Marc Lavoie ,  Marilaine Mota-Meira ,  Christophe Lacroix ,  Gisèle LaPointe

发明人： Marc Lavoie ,  Marilaine Mota-Meira ,  Christophe Lacroix ,  Gisèle LaPointe

IPC分类号： A61K3800

CPC分类号： C07K14/315 ,  A61K38/00

摘要： Mutacin are bactericidal substances of proteinaceous natures produced by Streptococcus mutans. Lantibiotics are antibacterial substances containing posttranslationnally modified amino acids such as lanthionine. The present invention teaches a simple method of purifying mutacin B-Ny266 from Streptococcus mutans strain Ny266 to homogeneity. The present invention further teaches the primary amino acid sequence of mutacin B-Ny266 as well as its proposed modified structure. Further, the present invention teaches compositions comprising mutacin B-Ny266 as well as methods for the treatment and/or prophylaxy of bacterial infections comprising an administration of a suitable dose of composition comprising mutacin B-Ny266.

摘要翻译： 变态链霉菌是由变形链球菌产生的蛋白质性质的杀菌物质。 拉链抗生素是含有经过翻译后修饰的氨基酸如羊毛硫蛋白的抗菌物质。 本发明教导了将Mutacin B-Ny266从变异链球菌菌株Ny266纯化为均质的简单方法。 本发明进一步教导了Mutacin B-Ny266的初级氨基酸序列以及其提出的修饰结构。 此外，本发明教导了包含mutacin B-Ny266的组合物以及用于治疗和/或预防细菌感染的方法，包括给予包含Mutacin B-Ny266的合适剂量的组合物。

公开(公告)号：US06699839B1

公开(公告)日：2004-03-02

申请号：US09691150

申请日：2000-10-19

申请人： Marc Lavoie ,  Marilaine Mota-Meira ,  Christophe Lacroix ,  Gisèle Lapointe

发明人： Marc Lavoie ,  Marilaine Mota-Meira ,  Christophe Lacroix ,  Gisèle Lapointe

IPC分类号： A61K3800

CPC分类号： C07K14/315 ,  A61K38/00

摘要： Mutacin are bactericidal substances of proteinaceous natures produced by Streptococcus mutans. Lantibiotics are antibacterial substances containing posttranslationnally modified amino acids such as lanthionine. The present invention teaches a simple method of purifying mutacin B-Ny266 from Streptococcus mutans strain Ny266 to homogeneity. The present invention further teaches the primary amino acid sequence of mutacin B-Ny266 as well as its proposed modified structure. Further, the present invention teaches compositions comprising mutacin B-Ny266 as well as methods for the treatment and/or prophylaxy of bacterial infections comprising an administration of a suitable dose of composition comprising mutacin B-Ny266.

摘要翻译： 变态链霉菌是由变形链球菌产生的蛋白质性质的杀菌物质。 拉链抗生素是含有经过翻译后修饰的氨基酸如羊毛硫蛋白的抗菌物质。 本发明教导了将Mutacin B-Ny266从变异链球菌菌株Ny266纯化为均质的简单方法。 本发明进一步教导了Mutacin B-Ny266的初级氨基酸序列以及其提出的修饰结构。 此外，本发明教导了包含mutacin B-Ny266的组合物以及用于治疗和/或预防细菌感染的方法，包括给予包含Mutacin B-Ny266的合适剂量的组合物。