Hypoxanthine-guanine phosphoribosyl transferase
    1.
    发明授权
    Hypoxanthine-guanine phosphoribosyl transferase 失效
    次黄嘌呤 - 鸟嘌呤磷酸核糖转移酶

    公开(公告)号:US06248577B1

    公开(公告)日:2001-06-19

    申请号:US07552744

    申请日:1990-07-16

    CPC classification number: C12Y204/02008 C12N9/1077

    Abstract: The present invention describes the previously unreported cloning and isolation of HGPRT cDNA containing an open reading frame corresponding to the HGPRT of Plasmodium falciparum, present the complete nucleotide sequence of the Plasmodium falciparum HGPRT Dral/Pstl cDNA fragment, and the expression of this gene product in an E. coli strain deficient in purine salvage.

    Abstract translation: 本发明描述了以前未报道的克隆和分离含有对应于恶性疟原虫的HGPRT的开放阅读框的HGPRT cDNA,其存在恶性疟原虫HGPRT Dral / Pst1 cDNA片段的完整核苷酸序列,并且该基因产物的表达 缺乏嘌呤补救的大肠杆菌菌株。

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