公开(公告)号：US12178655B2

公开(公告)日：2024-12-31

申请号：US18132086

申请日：2023-04-07

Applicant: BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY ACADEMY CO., LTD. ,  GENERAL HOSPITAL OF CHINESE PLA ,  SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

Inventor： Yukun Luo ,  Xiang Fei ,  Xirui Zhang ,  Maodong Sang ,  Lei Zhu ,  Yuxin Chen ,  Yan Zhang ,  Fang Xie ,  Yiru Wang ,  Duo Dong

IPC: A61B8/08 ,  A61B8/00 ,  A61B8/06

Abstract: Embodiments of the present disclosure provide a contrast enhanced ultrasound imaging method and an ultrasound imaging device. The method may include: determining a target imaging mode from preset imaging modes in response to the first instruction, where the preset imaging modes comprise a first contrast enhanced imaging mode and a second contrast enhanced imaging mode which have different frame rate; transmitting ultrasound waves to a target object and receiving ultrasound echoes returned from the target object according to the determined target imaging mode to obtain ultrasound echo signals; and generating a contrast enhanced image according to the ultrasound echo signals. An ultrasound imaging device is also be provided.

公开(公告)号：US11020450B2

公开(公告)日：2021-06-01

申请号：US15748621

申请日：2016-04-19

Applicant: GENERAL HOSPITAL OF CHINESE PLA NORTHERN THEATER COMMAND

Inventor： Yaling Han ,  Chenghui Yan ,  Dan Liu ,  Xiaoxiang Tian ,  Yang Li ,  Xiaolin Zhang ,  Haixu Song ,  Meili Liu

IPC: A61K38/00 ,  C07K14/00 ,  A61K38/17 ,  G01N33/68 ,  C07K14/47 ,  A01K67/027 ,  A61P9/10 ,  C12N15/52 ,  A61K48/00

Abstract: The present invention relates to a medical use of Cellular Repressor of E1A-stimulated Genes (CREG), in particular to a use of CREG protein or active fragment thereof in manufacture of a medicament for preventing and/or treating myocardial infarction, a use in manufacture of a medicament for preventing and/or treating ventricular remodeling after myocardial infarction and heart failure after myocardial infarction, a use in manufacture of a medicament for prevention and/or treatment of myocardial ischemia-reperfusion injury, a use in manufacture of a medicament for prevention and/or treatment of salt-sensitive hypertensive myocardial fibrosis.

公开(公告)号：US20200281571A1

公开(公告)日：2020-09-10

申请号：US16883884

申请日：2020-05-26

Applicant: BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY ACADEMY CO., LTD. ,  GENERAL HOSPITAL OF CHINESE PLA ,  SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

Inventor： Yukun LUO ,  Xiang FEI ,  Xirui ZHANG ,  Maodong SANG ,  Lei ZHU ,  Yuxin CHEN ,  Yan ZHANG ,  Fang XIE ,  Yiru WANG ,  Duo DONG

IPC: A61B8/08 ,  A61B8/06 ,  A61B8/00

Abstract: Embodiments of the present disclosure provide a contrast enhanced ultrasound imaging method and an ultrasound imaging device. The method may include: determining a target imaging mode from preset imaging modes in response to the first instruction, where the preset imaging modes comprise a first contrast enhanced imaging mode and a second contrast enhanced imaging mode which have different frame rate; transmitting ultrasound waves to a target object and receiving ultrasound echoes returned from the target object according to the determined target imaging mode to obtain ultrasound echo signals; and generating a contrast enhanced image according to the ultrasound echo signals. An ultrasound imaging device is also be provided.

公开(公告)号：US20230240660A1

公开(公告)日：2023-08-03

申请号：US18132086

申请日：2023-04-07

Applicant: BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY ACADEMY CO., LTD. ,  GENERAL HOSPITAL OF CHINESE PLA ,  SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

Inventor： Yukun LUO ,  Xiang FEI ,  Xirui ZHANG ,  Maodong SANG ,  Lei ZHU ,  Yuxin CHEN ,  Yan ZHANG ,  Fang XIE ,  Yiru WANG ,  Duo DONG

IPC: A61B8/08 ,  A61B8/06 ,  A61B8/00

CPC classification number: A61B8/5207 ,  A61B8/06 ,  A61B8/461 ,  A61B8/481

Abstract: Embodiments of the present disclosure provide a contrast enhanced ultrasound imaging method and an ultrasound imaging device. The method may include: determining a target imaging mode from preset imaging modes in response to the first instruction, where the preset imaging modes comprise a first contrast enhanced imaging mode and a second contrast enhanced imaging mode which have different frame rate; transmitting ultrasound waves to a target object and receiving ultrasound echoes returned from the target object according to the determined target imaging mode to obtain ultrasound echo signals; and generating a contrast enhanced image according to the ultrasound echo signals. An ultrasound imaging device is also be provided.

公开(公告)号：US11672512B2

公开(公告)日：2023-06-13

申请号：US16883884

申请日：2020-05-26

Applicant: BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY ACADEMY CO., LTD. ,  GENERAL HOSPITAL OF CHINESE PLA ,  SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

Inventor： Yukun Luo ,  Xiang Fei ,  Xirui Zhang ,  Maodong Sang ,  Lei Zhu ,  Yuxin Chen ,  Yan Zhang ,  Fang Xie ,  Yiru Wang ,  Duo Dong

IPC: A61B8/08 ,  A61B8/06 ,  A61B8/00

CPC classification number: A61B8/5207 ,  A61B8/06 ,  A61B8/461 ,  A61B8/481

Abstract: Embodiments of the present disclosure provide a contrast enhanced ultrasound imaging method and an ultrasound imaging device. The method may include: determining a target imaging mode from preset imaging modes in response to the first instruction, where the preset imaging modes comprise a first contrast enhanced imaging mode and a second contrast enhanced imaging mode which have different frame rate; transmitting ultrasound waves to a target object and receiving ultrasound echoes returned from the target object according to the determined target imaging mode to obtain ultrasound echo signals; and generating a contrast enhanced image according to the ultrasound echo signals. An ultrasound imaging device is also provided.

公开(公告)号：US20190216894A1

公开(公告)日：2019-07-18

申请号：US16323950

申请日：2017-07-26

Applicant: GENERAL HOSPITAL OF CHINESE PLA NORTHERN THEATER COMMAND

Inventor： Yaling HAN ,  Xiaoxiang TIAN ,  Chenghui YAN ,  Quanyu ZHANG ,  Xiaolin ZHANG ,  Dan LIU

IPC: A61K38/17 ,  A61P3/04 ,  A61P3/08 ,  A61P3/06 ,  A61P1/16

CPC classification number: A61K38/1709 ,  A61K38/17 ,  A61P1/16 ,  A61P3/04 ,  A61P3/06 ,  A61P3/08 ,  A61P5/50

Abstract: Described is the use of an E1A activating gene repressor (CREG) protein, in particular to a use of a CREG protein or an active fragment thereof in manufacture of a medicament for prevention and/or treatment of overweight, obesity, insulin resistance, hyperlipidemia and related diseases. Also described is the use of a recombinant vector or recombinant cell expressing a CREG protein or an active fragment thereof in manufacture of a medicament for prevention and/or treatment of overweight, obesity, insulin resistance, hyperlipidemia and related diseases.

公开(公告)号：US11737734B2

公开(公告)日：2023-08-29

申请号：US16849958

申请日：2020-04-15

Applicant: BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD. ,  GENERAL HOSPITAL OF CHINESE PLA ,  SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

Inventor： Xirui Zhang ,  Jie Tang ,  Yukun Luo ,  Mingbo Zhang ,  Maodong Sang ,  Lanxi Xiang ,  Donghai Qin ,  Wei Fan

IPC: A61B8/08 ,  G06T5/00 ,  G06T5/50 ,  G06T7/00

CPC classification number: A61B8/481 ,  G06T5/007 ,  G06T5/50 ,  G06T7/0012 ,  A61B8/5207 ,  G06T2207/10132 ,  G06T2207/20056

Abstract: An ultrasound imaging device and system, and an image enhancement method for ultrasound radiography and imaging. Image enhancement coefficients of location points in a examined biological tissue are computed first according to radiography channel data, and then, weighted processing is performed on the image enhancement coefficients and beam forming data.

公开(公告)号：US20200253586A1

公开(公告)日：2020-08-13

申请号：US16849958

申请日：2020-04-15

Applicant: BEIJING SHEN MINDRAY MEDICAL ELECTRONICS TECHNOLOGY RESEARCH INSTITUTE CO., LTD. ,  GENERAL HOSPITAL OF CHINESE PLA ,  SHENZHEN MINDRAY BIO-MEDICAL ELECTRONICS CO., LTD.

Inventor： Xirui ZHANG ,  Jie TANG ,  Yukun LUO ,  Mingbo ZHANG ,  Maodong SANG ,  Lanxi XIANG ,  Donghai QIN ,  Wei FAN

IPC: A61B8/08 ,  G06T7/00 ,  G06T5/00 ,  G06T5/50

Abstract: An ultrasound imaging device and system, and an image enhancement method for ultrasound radiography and imaging. Image enhancement coefficients of location points in a examined biological tissue are computed first according to radiography channel data, and then, weighted processing is performed on the image enhancement coefficients and beam forming data.

公开(公告)号：US20200147172A1

公开(公告)日：2020-05-14

申请号：US16474903

申请日：2017-12-21

Applicant: GENERAL HOSPITAL OF CHINESE PLA NORTHERN THEATER COMMAND

Inventor： Yaling HAN ,  Quanyu ZHANG ,  Chenghui YAN ,  Xiaoxiang TIAN

IPC: A61K38/17 ,  C12N15/85 ,  A61P3/10 ,  A01K67/027

Abstract: The present invention relates to a use of cellular repressor of E1A-stimulated genes (CREG) protein, and in particular to a use of a CREG protein or an active fragment thereof in manufacture of a medicament for the prevention and/or treatment of a fatty liver disease and type 2 diabetes. The present invention also relates to a use of a recombinant vector or recombinant cell expressing a CREG protein or an active fragment thereof in manufacture of a medicament for the prevention and/or treatment of a fatty liver disease and type 2 diabetes. The invention also relates to a corresponding kit, such as a kit used for the predication and/or evaluation of therapeutic effect and prognosis of a fatty liver disease and type 2 diabetes.