公开(公告)号：US5583125A

公开(公告)日：1996-12-10

申请号：US132176

申请日：1993-10-06

申请人： Andreas Steinmeyer ,  G unter Neef ,  Gerald Kirsch ,  Katica Schwarz ,  Ruth Thieroff-Ekerdt ,  Herbert Wiesinger ,  Martin Haberey

发明人： Andreas Steinmeyer ,  G unter Neef ,  Gerald Kirsch ,  Katica Schwarz ,  Ruth Thieroff-Ekerdt ,  Herbert Wiesinger ,  Martin Haberey

IPC分类号： A61K31/59 ,  A61P3/02 ,  A61P3/08 ,  A61P11/00 ,  A61P17/00 ,  A61P31/12 ,  A61P35/00 ,  A61P37/00 ,  A61P37/04 ,  A61P43/00 ,  C07C401/00

CPC分类号： C07C401/00

摘要： New 25-carboxylic acid derivatives of general formula I, ##STR1## R.sup.19 and R.sup.19a each mean a hydrogen atom or together form an exocyclic methylene group,R.sup.21 and R.sup.21a independently of one another mean a hydrogen atom, a chlorine or fluorine atom, an alkyl group with 1 to 4 carbon atoms, together a methylene group, together with quaternary carbon atom 20 mean a 3-7 membered, saturated or unsaturated carboxylic ring,Y preferably means a derivatized carboxyl radical, and the other substituents have the meanings indicated in the description as well as process for their production, are described.The new compounds have vitamin D activity as well as proliferation-inhibiting and cell-differentiating effects and are suitable for the production of pharmaceutical agents.

摘要翻译： 通式I，（I）R 19和R 19a的新的25-羧酸衍生物各自表示氢原子或一起形成环外亚甲基，R 21和R 21a彼此独立地表示氢原子，氯或氟原子 ，具有1至4个碳原子的烷基，一起亚甲基与季碳原子20一起表示3-7元饱和或不饱和羧基，Y优选是衍生化的羧基，其它取代基具有以下含义： 在描述中指出了它们的生产过程。 新化合物具有维生素D活性以及增殖抑制和细胞分化作用，适用于制药。