公开(公告)号：US5455363A

公开(公告)日：1995-10-03

申请号：US957677

申请日：1992-10-07

申请人： Jacques Gosteli ,  Beat Sax ,  Fritz Dick ,  Rudolf Tanner

发明人： Jacques Gosteli ,  Beat Sax ,  Fritz Dick ,  Rudolf Tanner

IPC分类号： C07C237/06 ,  C07C271/22 ,  C07K1/06 ,  C07K7/04

CPC分类号： C07C237/06 ,  C07C271/22 ,  C07K1/066 ,  C07C2103/18 ,  Y02P20/55

摘要： Compounds of formula I are described, ##STR1## wherein n is equal to one or two, R.sub.1 stands for hydrogen or an amino protecting group, R.sub.2 represents hydrogen or a carboxyl protecting group and R.sub.3 4-methyltriphenylmethyl, 4,4'-dimethyltriphenylmethyl, 4,4',4"-trimethyltriphenylmethyl. Furthermore described are compounds of formula I which are reactive and suitable for coupling reactions and are derived from I with R.sub.2 =H by activation of the carboxyl group.The compounds mentioned above can be used as starting materials for the synthesis of peptides. They are more suitable than analogous compounds of formula I, wherein R.sub.3 represents hydrogen or a carbamoyl protecting group used hitherto.

摘要翻译： 描述式I化合物，其中n等于1或2，R1代表氢或氨基保护基，R2代表氢或羧基保护基，R3,4-甲基三苯基甲基，4,4'-二甲基三苯基甲基 ，4,4'，4“ - 三甲基三苯基甲基。 此外还描述了反应性和适用于偶联反应的式I化合物，并且通过活化羧基得到R 2 = H的I化合物。 上述化合物可以用作合成肽的起始原料。 它们比类似式I化合物更合适，其中R 3表示氢或迄今使用的氨基甲酰基保护基。