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公开(公告)号：US07294719B2
公开(公告)日：2007-11-13
申请号：US11259672
申请日：2005-10-26
IPC分类号： C07D207/12 , C07C227/02
CPC分类号： C07D263/44 , C07D207/12
摘要： A process for producing N-carboxyanhydrides is disclosed. The process produces N-carboxyanhydrides as a product and HCl as a by-product. The HCl by-product is purged from the reaction mixture by passing a purge gas through the reaction mixture as a carbonylation reagent is reacting with an amino acid or a salt thereof. The N-carboxyanhydrides produced by this process have a relatively lower chloride impurity content, relatively higher yields can be achieved, and the N-carboxyanhydrides can be produced on a larger scale.
摘要翻译： 公开了一种生产N-羧酸酐的方法。 该方法产生作为产物的N-羧酸酐和作为副产物的HCl。 当羰基化试剂与氨基酸或其盐反应时，通过使清洗气体通过反应混合物，将HCl副产物从反应混合物中吹扫。 通过该方法制备的N-羧酸酐具有相对较低的氯化物杂质含量，可以获得相对较高的产率，并且可以以更大规模生产N-羧酸酐。
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公开(公告)号：US20120071612A1
公开(公告)日：2012-03-22
申请号：US13255126
申请日：2010-03-08
IPC分类号： C08G69/48
摘要： The present invention provides a method for the production of polyamino acid copolymers. In particular, the method may be utilized to produce high quality polyamino acid random copolymers.
摘要翻译： 本发明提供了制备聚氨基酸共聚物的方法。 特别地，该方法可用于生产高质量的聚氨基酸无规共聚物。
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3.发明申请Preparation of Low Molecular Weight Polylysine and Polyornithine in High Yield 有权低分子量聚赖氨酸和聚鸟氨酸在高产量下的制备公开(公告)号：US20110054146A1
公开(公告)日：2011-03-03
申请号：US12863131
申请日：2009-07-29
IPC分类号： C07K14/00
CPC分类号： C08G69/04 , C07K14/001 , C08G69/10
摘要： The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons. In preferred embodiments, the polymer is a homopolymer of poly-L-lysine.
摘要翻译： 本发明通常涉及通过制备重均分子量为约12,500道尔顿至约22,000道尔顿的聚赖氨酸或聚鸟氨酸，以高产率大规模（例如，大于1千克标度）制备低分子量聚赖氨酸或多聚赖氨酸 并水解，以产生重均分子量约为5,500道尔顿至约12,000道尔顿的聚赖氨酸或聚鸟氨酸。 在优选的实施方案中，聚合物是聚-L-赖氨酸的均聚物。
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公开(公告)号：US08791226B2
公开(公告)日：2014-07-29
申请号：US13759247
申请日：2013-02-05
IPC分类号： C08G69/10
CPC分类号： C08G69/04 , C07K14/001 , C08G69/10
摘要： The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons.
摘要翻译： 本发明通常涉及通过制备重均分子量为约12,500道尔顿至约22,000道尔顿的聚赖氨酸或聚鸟氨酸，以高产率大规模（例如，大于1千克标度）制备低分子量聚赖氨酸或多聚赖氨酸 并水解以产生重均分子量为约5,500道尔顿至约12,000道尔顿的聚赖氨酸或聚鸟氨酸。
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公开(公告)号：US20130172517A1
公开(公告)日：2013-07-04
申请号：US13759247
申请日：2013-02-05
IPC分类号： C08G69/04
CPC分类号： C08G69/04 , C07K14/001 , C08G69/10
摘要： The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons.
摘要翻译： 本发明通常涉及通过制备重均分子量为约12,500道尔顿至约22,000道尔顿的聚赖氨酸或聚鸟氨酸，以高产率大规模（例如，大于1千克标度）制备低分子量聚赖氨酸或多聚赖氨酸 并水解以产生重均分子量为约5,500道尔顿至约12,000道尔顿的聚赖氨酸或聚鸟氨酸。
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6.发明授权Preparation of low molecular weight polylysine and polyornithine in high yield 有权以高产率制备低分子量聚赖氨酸和聚鸟氨酸公开(公告)号：US08399600B2
公开(公告)日：2013-03-19
申请号：US12863131
申请日：2009-07-29
IPC分类号： C08G69/10
CPC分类号： C08G69/04 , C07K14/001 , C08G69/10
摘要： The present invention generally relates to the large-scale (e.g., greater than 1 kg scale) preparation of low molecular weight polylysine or polyornithine in high yield by preparing a polylysine or polyornithine having a weight average molecular weight from about 12,500 Daltons to about 22,000 Daltons and hydrolyzing it to produce a polylysine or polyornithine having a weight average molecular weight from about 5,500 Daltons to about 12,000 Daltons. In preferred embodiments, the polymer is a homopolymer of poly-L-lysine.
摘要翻译： 本发明通常涉及通过制备重均分子量为约12,500道尔顿至约22,000道尔顿的聚赖氨酸或聚鸟氨酸，以高产率大规模（例如，大于1千克标度）制备低分子量聚赖氨酸或多聚赖氨酸 并水解以产生重均分子量为约5,500道尔顿至约12,000道尔顿的聚赖氨酸或聚鸟氨酸。 在优选的实施方案中，聚合物是聚-L-赖氨酸的均聚物。
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公开(公告)号：US20120123094A1
公开(公告)日：2012-05-17
申请号：US13295183
申请日：2011-11-14
IPC分类号： C07K1/06
摘要： The present invention provides a greener method for the production of polyamino acid random copolymers containing alanine, glutamic acid, lysine and tyrosine. In particular, the present invention provides a greener method for the production of Copolymer 1 or a pharmaceutically acceptable salt thereof via a synthetic route that only requires a single deprotection step.
摘要翻译： 本发明提供了生产含有丙氨酸，谷氨酸，赖氨酸和酪氨酸的聚氨基酸无规共聚物的更环保的方法。 特别地，本发明提供了通过仅需要单一脱保护步骤的合成途径生产共聚物1或其药学上可接受的盐的更环保的方法。
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公开(公告)号：US07317070B1
公开(公告)日：2008-01-08
申请号：US11077450
申请日：2005-03-10
IPC分类号： C08G69/10
CPC分类号： C08G73/028
摘要： Among the various aspects of the present invention is an improved process for the preparation of polyamino acids generally, and more specifically, polyglutamic acid and polyaspartic acid. Another aspect is a process for the large scale (i.e. >1 kg) preparation of polyamino acids; particularly polyglutamic and polyaspartic acid.
摘要翻译： 本发明的各个方面是通常制备聚氨基酸，更具体地说是聚谷氨酸和聚天冬氨酸的改进方法。 另一方面是大规模（即> 1kg）制备聚氨基酸的方法; 特别是聚谷氨酸和聚天冬氨酸。
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公开(公告)号：US20060106229A1
公开(公告)日：2006-05-18
申请号：US11259672
申请日：2005-10-26
IPC分类号： C07D207/12 , C07C227/02
CPC分类号： C07D263/44 , C07D207/12
摘要： A process for producing N-carboxyanhydrides is disclosed. The process produces N-carboxyanhydrides as a product and HCl as a by-product. The HCl by-product is purged from the reaction mixture by passing a purge gas through the reaction mixture as a carbonylation reagent is reacting with an amino acid or a salt thereof. The N-carboxyanhydrides produced by this process have a relatively lower chloride impurity content, relatively higher yields can be achieved, and the N-carboxyanhydrides can be produced on a larger scale.
摘要翻译： 公开了一种生产N-羧酸酐的方法。 该方法产生作为产物的N-羧酸酐和作为副产物的HCl。 当羰基化试剂与氨基酸或其盐反应时，通过使清洗气体通过反应混合物，将HCl副产物从反应混合物中吹扫。 通过该方法制备的N-羧酸酐具有相对较低的氯化物杂质含量，可以获得相对较高的产率，并且可以以更大规模生产N-羧酸酐。
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