公开(公告)号：US20110071129A1

公开(公告)日：2011-03-24

申请号：US12993928

申请日：2009-06-11

Applicant: Makoto Ando ,  Etsuki Hirose ,  Kouta Masutani ,  Minoru Moriya ,  Takao Suzuki

Inventor： Makoto Ando ,  Etsuki Hirose ,  Kouta Masutani ,  Minoru Moriya ,  Takao Suzuki

IPC: A61K31/4427 ,  C07D487/10 ,  A61K31/444 ,  A61P3/04 ,  A61P3/10 ,  A61P1/16 ,  A61P25/24 ,  A61P25/22 ,  A61K31/5025 ,  A61K31/497

CPC classification number: C07D471/20 ,  A61K31/13 ,  C07D487/10 ,  C07D519/00

Abstract: [Problem] To provide a melanin concentrating hormone receptor antagonist useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders.[Means for Resolution] Provided are compound of a formula (I): [wherein R1 a and R1 b each are a hydrogen atom, etc.; R2 is a hydrogen atom, a C1-6 alkyl, etc.; Ar1 is a 6-membered aromatic carbocyclic group or a 6-membered aromatic nitrogen-containing heterocyclic group; Ar2 is a group to be formed by removing two hydrogen atoms from a 6-membered aromatic carbon ring, a 6-membered aromatic nitrogen-containing hetero ring, etc.; Ar3 is a mono- or bi-cyclic aromatic carbon ring or aromatic hetero ring; m1, m2, m3 and m4 each are independently 0, 1, 2, 3 or 4, provided that the total of m1 and m2 is from 2 to 6, the total of m3 and m4 is from 2 to 6]. The compounds are useful as medicines for central system disorders, cardiovascular disorders, metabolic disorders.

Abstract translation: [问题]提供可用作中枢系统疾病，心血管疾病，代谢紊乱的药物的黑色素浓缩激素受体拮抗剂。 [分解方法]提供式（I）的化合物：[其中R1 a和R1b各自为氢原子等; R2是氢原子，C1-6烷基等; Ar 1是6元芳族碳环基或6元芳族含氮杂环基; Ar 2是通过从6元芳族碳环，6元芳族含氮杂环等除去2个氢原子而形成的基团; Ar 3是单环或双环芳族碳环或芳族杂环; m1，m2，m3和m4各自独立为0,1,2,3或4，条件是m1和m2的总和为2至6，m3和m4的总和为2至6]。 该化合物可用作中枢系统疾病，心血管疾病，代谢紊乱的药物。