公开(公告)号：US09101298B2

公开(公告)日：2015-08-11

申请号：US13182067

申请日：2011-07-13

Applicant: Norman Hugh Hossack ,  Stephen Charles Davies ,  Donald Mamayek ,  Richard Scott Huennekens ,  Stephen M. Fry ,  Eric Vaughn Mott ,  Peter Smith ,  Scott Tennant Brownlie ,  Jon David Klingensmith ,  Richard Chester Klosinski, Jr. ,  Edward Anthony Oliver ,  Masood Ahmed ,  Gerald Lea Litzza

Inventor： Norman Hugh Hossack ,  Stephen Charles Davies ,  Donald Mamayek ,  Richard Scott Huennekens ,  Stephen M. Fry ,  Eric Vaughn Mott ,  Peter Smith ,  Scott Tennant Brownlie ,  Jon David Klingensmith ,  Richard Chester Klosinski, Jr. ,  Edward Anthony Oliver ,  Masood Ahmed ,  Gerald Lea Litzza

IPC: A61B8/14 ,  A61B8/00 ,  A61B8/12 ,  A61B1/00 ,  G06K19/077

CPC classification number: A61B8/12 ,  A61B1/00059 ,  A61B8/4438 ,  A61B8/4472 ,  A61B2090/0803 ,  G06K19/07749

Abstract: A method and system is provided for using backscattered data and known parameters to characterize vascular tissue. Specifically, methods and devices for identifying information about the imaging element used to gather the backscattered data are provided in order to permit an operation console having a plurality of Virtual Histology classification trees to select the appropriate VH classification tree for analyzing data gathered using that imaging element. In order to select the appropriate VH database for analyzing data from a specific imaging catheter, it is advantageous to know information regarding the function and performance of the catheter, such as the operating frequency of the catheter and whether it is a rotational or phased-array catheter. The present invention provides a device and method for storing this information on the imaging catheter and communicating the information to the operation console. In addition, information related to additional functions of the catheter may also be stored on the catheter and used to further optimize catheter performance and/or select the appropriate Virtual Histology classification tree for analyzing data from the catheter imaging element.

Abstract translation: 提供了一种使用反向散射数据和已知参数来表征血管组织的方法和系统。 具体地，提供了用于识别用于收集背散射数据的成像元件的信息的方法和装置，以便允许具有多个虚拟组织学分类树的操作控制台选择适当的VH分类树，以分析使用该成像元件收集的数据 。 为了选择用于分析来自特定成像导管的数据的适当的VH数据库，有利的是知道关于导管的功能和性能的信息，例如导管的操作频率以及它是旋转的还是相控阵的 导管。 本发明提供了一种用于将该信息存储在成像导管上并将信息传送到操作台的装置和方法。 此外，与导管的附加功能相关的信息也可以存储在导管上并且用于进一步优化导管性能和/或选择适当的虚拟组织学分类树来分析来自导管成像元件的数据。

公开(公告)号：US20100028860A1

公开(公告)日：2010-02-04

申请号：US12548597

申请日：2009-08-27

Applicant: Michael Roof ,  Eric Vaughn ,  Wesley Johnson

Inventor： Michael Roof ,  Eric Vaughn ,  Wesley Johnson

IPC: C12Q1/70

CPC classification number: C12N7/00 ,  C12N2770/10031

Abstract: A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.

Abstract translation: 提供了一种预测新型或非特异性PRRS病毒株的毒力的方法，其中将菌株注射到猪中并允许复制约3-15天的时间。 在此期间，确定病毒增长率和/或病毒血症的大小，并将该数据与已知毒力的PRRS病毒株的相应生长速率和/或病毒血症量进行比较，作为毒力 新的或未表征的菌株。

公开(公告)号：US20080279893A1

公开(公告)日：2008-11-13

申请号：US11414764

申请日：2006-04-28

Applicant: Eric Vaughn ,  Merrill Schaeffer ,  Yajie Liang

Inventor： Eric Vaughn ,  Merrill Schaeffer ,  Yajie Liang

IPC: A61K39/00 ,  C07K14/00 ,  C12N15/11 ,  C12N15/00 ,  G01N33/569 ,  A61K31/70 ,  A61K38/00

CPC classification number: C07K14/195 ,  C07K16/12 ,  G01N33/56911 ,  G01N2469/20

Abstract: The present invention provides nucleic acid and amino acid sequences useful as the immunogenic portion of vaccines or immunogenic compositions effective for lessening the severity of the clinical symptoms associated with Lawsonia intracellularis infection or conferring protective immunity to an animal susceptible to such infection. Preferred amino acid sequences are selected from the group consisting of 1) a polypeptide comprising a sequence selected from the group consisting of SEQ ID Nos.: 1-455, SEQ ID No 466, or the polypeptide encoded by SEQ ID No: 456, SEQ ID No: 457 or SEQ ID No: 466; 2) any polypeptide that has at least 85% sequence homology, more preferably at least about 90% sequence homology, still more preferably at least about 95% sequence homology, even more preferably at least about 97% sequence homology, still even more preferably at least about 98% sequence homology, and even more preferably at least about 99% sequence homology to the polypeptide of 1); 3) any immunogenic portion of the polypeptides of 1) and/or 2) 4) the immunogenic portion of 3), comprising at least 300, 290, 280, 270, 260, 250, 240, 230, 220, 210, 200, 190, 180, 170, 160, 150, 140, 130, 120, 110, 100, 90, 80, 70, 60, 50, 45, 40, 35, 30, 25, 20, 18, 15, 13, 10, or most preferably 9 contiguous amino acids included in the sequences of SEQ ID No: 1-455, SEQ ID No: 456, or the amino acid sequence encoded by SEQ ID No: 457 or SEQ ID No: 466; and/or 5) a polypeptide that is encoded by a DNA that codes for a peptide comprising the sequence of SEQ ID No: 1-455 or SEQ ID No: 466. Thus, the nucleic acid sequences encoding such proteins, or the proteins themselves are included in vaccine compositions, together with veterinary-acceptable carrier and administered to an animal in need thereof.

Abstract translation: 本发明提供了可用作疫苗或免疫原性组合物的免疫原性部分的核酸和氨基酸序列，其有效减轻与胞内劳森氏菌感染相关的临床症状的严重性或赋予对这种感染易感的动物的保护性免疫。 优选的氨基酸序列选自1）包含选自SEQ ID No：1-455，SEQ ID No 466或由SEQ ID No：456编码的多肽的序列的SEQ ID NO：456所示的多肽 ID号：457或SEQ ID No：466; 2）与序列同源性至少85％，更优选至少约90％的序列同源性，更优选至少约95％的序列同源性，甚至更优选至少约97％的序列同源性的任何多肽，甚至更优选在 至少约98％的序列同源性，甚至更优选至少约99％与1）多肽的序列同源性; 3）1）和/或2）的多肽的任何免疫原性部分和/或2）4）3）的免疫原性部分，其包含至少300,290,280,270,260,250,240,230,220,210,2200， 190，180，170，160，150，140，130，120，110，100，90，80，70，60，50，45，40，35，30，25，20，18，15，13， 或最优选9个连续氨基酸，包括在SEQ ID No：1-455，SEQ ID No：456或由SEQ ID No：457或SEQ ID No：466编码的氨基酸序列中; 和/或5）由编码包含SEQ ID No：1-455或SEQ ID No：466的序列的肽的DNA编码的多肽。因此，编码这些蛋白质或蛋白质本身的核酸序列 包括在疫苗组合物中，以及兽医学可接受的载体并且施用于有需要的动物。

公开(公告)号：US08838308B2

公开(公告)日：2014-09-16

申请号：US13117602

申请日：2011-05-27

Applicant: Eric Vaughn Meyers

Inventor： Eric Vaughn Meyers

IPC: B60L11/00

CPC classification number: B62K11/10 ,  B60L3/04 ,  B60L15/2036 ,  B60L2200/12 ,  B60L2200/24 ,  B60L2220/44 ,  B62J17/00 ,  B62K2204/00 ,  B62K2208/00 ,  Y02T10/645 ,  Y02T10/72 ,  Y02T10/7275 ,  Y02T90/16

Abstract: A two wheeled vehicle includes a main body, a first wheel that is coupled to the main body, and a second wheel that is coupled to the main body. The vehicle also includes a motor that is supported by the main body and that drives at least one of the first and second wheels in rotation relative to the main body. Moreover, the vehicle includes a controller assembly including a controller and a controller housing. The controller is operable to control the motor to thereby control driving rotation of the at least one of the first and second wheels. The controller is housed within the controller housing, and the controller housing is coupled to the main body. The controller and the motor are in severable but operable communication when the controller housing is coupled to the main body.

Abstract translation: 两轮车包括主体，联接到主体的第一轮和联接到主体的第二轮。 车辆还包括由主体支撑并驱动相对于主体旋转的第一和第二轮中的至少一个的马达。 此外，车辆包括控制器组件，其包括控制器和控制器壳体。 控制器可操作以控制马达，从而控制第一和第二轮中的至少一个的驱动旋转。 控制器容纳在控制器壳体内，并且控制器壳体联接到主体。 当控制器壳体耦合到主体时，控制器和电动机是可分离的但可操作的通信。

公开(公告)号：US08383131B2

公开(公告)日：2013-02-26

申请号：US13085692

申请日：2011-04-13

Applicant: Michael Roof ,  Eric Vaughn ,  Wesley Johnson

Inventor： Michael Roof ,  Eric Vaughn ,  Wesley Johnson

IPC: A61K39/00 ,  C12N7/00

CPC classification number: C12N7/00 ,  C12N2770/10031

Abstract: A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.

公开(公告)号：US20110195088A1

公开(公告)日：2011-08-11

申请号：US13085692

申请日：2011-04-13

Applicant: Michael Roof ,  Eric Vaughn ,  Wesley Johnson

Inventor： Michael Roof ,  Eric Vaughn ,  Wesley Johnson

IPC: A61K39/12 ,  C12N7/01 ,  A61P31/14

CPC classification number: C12N7/00 ,  C12N2770/10031

Abstract: A method of predicting the virulence of a new or uncharacterized PRRS virus strain is provided wherein the strain is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus strain of known virulence, as a measure of the virulence of the new or uncharacterized strain.

Abstract translation: 提供了一种预测新型或非特异性PRRS病毒株的毒力的方法，其中将菌株注射到猪中并允许复制约3-15天的时间。 在此期间，确定病毒增长率和/或病毒血症的大小，并将该数据与已知毒力的PRRS病毒株的相应生长速率和/或病毒血症量进行比较，作为毒力 新的或未表征的菌株。

公开(公告)号：US20110117129A1

公开(公告)日：2011-05-19

申请号：US13055590

申请日：2009-08-24

Applicant: Michael B. Roof ,  Eric Vaughn

Inventor： Michael B. Roof ,  Eric Vaughn

IPC: A61K39/225 ,  A61P37/00

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/552 ,  C12N2770/10034

Abstract: The present invention is related to methods and attenuated viral compositions for use in preventing and treating a high fever disease forms associated with porcine reproductive and respiratory syndrome (PRRS), such as highly pathogenic porcine reproductive and respiratory syndrome (HP PRRS), a viral disease affecting swine.

Abstract translation: 本发明涉及用于预防和治疗与猪繁殖与呼吸综合征（PRRS）相关的高发病形式的方法和减毒病毒组合物，例如高致病性猪繁殖与呼吸综合征（HP PRRS），病毒性疾病 影响猪。

公开(公告)号：US20090148474A1

公开(公告)日：2009-06-11

申请号：US12332127

申请日：2008-12-10

Applicant: Michael Roof ,  Eric Vaughn ,  Wesley Johnson

Inventor： Michael Roof ,  Eric Vaughn ,  Wesley Johnson

IPC: A61K39/12 ,  C12Q1/70 ,  A61K49/00

CPC classification number: C12N7/00 ,  C12N2770/10031 ,  C12Q1/701

Abstract: A method of predicting the virulence of a new or uncharacterized PRRS virus isolate is provided wherein the isolate is injected into swine and allowed to replicate for a period of from about 3-15 days. During this period, the rate of virus growth and/or the magnitude of viremia is determined, and this data is compared with a corresponding growth rate and/or viremia magnitude of a PRRS virus isolate of known virulence, as a measure of the virulence of the new or uncharacterized isolate. Additionally, a method of selecting an isolate for inclusion in an immunogenic composition based on the predicted virulence is also provided, together with compositions incorporating attenuated forms of viruses predicted to be virulent.

Abstract translation: 提供了一种预测新型或未表征的PRRS病毒分离物的毒力的方法，其中所述分离物被注射到猪中并允许复制约3-15天的时间。 在此期间，确定病毒生长率和/或病毒血症的大小，并将该数据与已知毒力的PRRS病毒分离株的相应生长速率和/或病毒血症量进行比较，作为毒力 新的或非特异性的分离物。 此外，还提供了基于预测的毒力选择包含在免疫原性组合物中的分离物的方法以及预测为有毒性的减毒病毒形式的组合物。

公开(公告)号：US20080222773A1

公开(公告)日：2008-09-18

申请号：US12077538

申请日：2008-03-17

Applicant: Eric Vaughn

Inventor： Eric Vaughn

IPC: A41D19/01

CPC classification number: A41D19/0017 ,  A41D19/01

Abstract: A hand covering configured to enclose a human hand, fingers and thumb, having a dorsal side and a palm side. The hand covering includes a wrist portion and a hand portion. The hand portion includes at least one digit receptacle and a thumb receptacle. An opening is formed in the dorsal side of the hand covering, and extends from a location rearward of the thumb receptacle, across the dorsal side, to a side of the hand covering opposite the thumb receptacle. The opening is configured to allow the digit receptacle and the thumb receptacle to be removed from the digits and thumb of the wearer, while the wrist portion remains attached to the wearer and covers a dorsal side of the wearer's hand.

Abstract translation: 一种手套，其被构造成包围具有背侧和手掌侧的人的手，手指和拇指。 手套包括腕部和手部。 手部包括至少一个数字插座和拇指插座。 在手套的背侧形成有开口，并且从拇指容器的后方位于背侧延伸到手指盖的与拇指容器相对的一侧。 开口构造成允许数字插座和拇指插座从佩戴者的数字和拇指移除，同时腕部保持附接到佩戴者并且覆盖佩戴者的手的背侧。

公开(公告)号：US20060260022A1

公开(公告)日：2006-11-23

申请号：US11133069

申请日：2005-05-18

Applicant: Eric Vaughn

Inventor： Eric Vaughn

IPC: A41D19/00

CPC classification number: A41D19/0017 ,  A41D19/01

Abstract: A hand covering configured to enclose a human hand, fingers and thumb, having a dorsal side and a palm side. The hand covering includes a wrist portion and a hand portion. The hand portion includes at least one digit receptacle and a thumb receptacle. An opening is formed in the dorsal side of the hand covering, and extends from a location rearward of the thumb receptacle, across the dorsal side, to a side of the hand covering opposite the thumb receptacle. The opening is configured to allow the digit receptacle and the thumb receptacle to be removed from the digits and thumb of the wearer, while the wrist portion remains attached to the wearer and covers a dorsal side of the wearer's hand.

Abstract translation: 一种手套，其被构造成包围具有背侧和手掌侧的人的手，手指和拇指。 手套包括腕部和手部。 手部包括至少一个数字插座和拇指插座。 在手套的背侧形成有开口，并且从拇指容器的后方位于背侧延伸到手指盖的与拇指容器相对的一侧。 开口构造成允许数字插座和拇指插座从佩戴者的数字和拇指移除，同时腕部保持附接到佩戴者并且覆盖佩戴者的手的背侧。