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公开(公告)号：US20110093243A1
公开(公告)日：2011-04-21
申请号：US12741526
申请日：2008-11-11
CPC分类号： G06T7/0012 , G06F17/5018 , G06F2217/16 , G06T17/20 , G06T2207/10081 , G06T2207/10088 , G06T2207/20068 , G06T2207/30061 , G06T2210/24 , G06T2210/41 , G16H50/50
摘要： A structural and functional model for a lung or similar organ is virtually defined by encoding aspects of branching passageways. Larger passageways that are visible in medical images are surface mesh fitted to the anatomical surface geometry. Smaller distal passageways, beyond a given number of branch generations, are modeled by inference as linear passages with nominal diameters and branching characteristics, virtually filling the space within the outer envelope of the organ. The model encodes finite volumetric elements for elasticity and compliance in passageway walls, and for local pressure and flow conditions in passageway lumens during respiration. The modeling can assess organ performance, help to plan surgery or therapy, determine likely particle deposition, assess respiratory pharmaceutical dosing, and otherwise represent structural and functional organ parameters.
摘要翻译： 肺或类似器官的结构和功能模型实际上通过编码分支通道的方面来定义。 在医学图像中可见的更大的通道是适合于解剖表面几何形状的表面网格。 超过给定数量的分支代的较小的远端通道通过推理作为具有公称直径和分支特征的线性通道来建模，实际上填充了器官外部外壳内的空间。 该模型编码有限体积元素，用于通道壁中的弹性和顺应性，以及呼吸期间通道腔内的局部压力和流量条件。 建模可以评估器官表现，帮助计划手术或治疗，确定可能的颗粒沉积，评估呼吸药物给药，以及否则表示结构和功能器官参数。
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2.发明授权Method and apparatus for analyzing CT images to determine the presence of pulmonary tissue pathology 失效用于分析CT图像以确定肺组织病理学存在的方法和装置公开(公告)号：US06466687B1
公开(公告)日：2002-10-15
申请号：US09022093
申请日：1998-02-11
IPC分类号： G06K900
CPC分类号： G06T7/0012
摘要： A method and apparatus for analyzing CT images to determine the presence of pulmonary tissue pathology, such as in emphysema, IPF, sarcoid, etc. In accordance with one embodiment, a CT slice is selected to perform an automated, objective, and quantitative analysis of the slice. Initially, an image processing stage is performed, which includes segmentation and edgementation of the selected CT slice for preparation of a series of objective, quantitative measures to be performed on the slice. A region of interest (ROI) is selected on the CT slice in which these objective, quatitative measures are to be taken. The first set of objective, quantitative measures are first order texture measures that describe a frequency of occurrence of all gray levels assigned to pixels within the ROI of the image slice. The second set of objective, quantitative measures are second order texture measures that characterize the spatial interdependencies between particular pixels of the ROI. Fractal analysis could also be performed to provide additional objective, quantitative measures of the ROI. The ROI is classified to a particular tissue pathology class based upon an optimal subset of first or second order texture measures and fractal measures obtained. A color-coded output is displayed for visual presentation to a user indicating the different tissue pathology classes assigned to different regions of the CT slice.
摘要翻译： 用于分析CT图像以确定肺组织病理学的存在的方法和装置，例如在肺气肿，IPF，结节样等中。根据一个实施例，选择CT切片以执行自动化，客观和定量分析 切片。 最初，执行图像处理阶段，其包括所选择的CT切片的分割和分割，以准备在切片上执行的一系列客观的定量测量。 在CT切片上选择感兴趣区域（ROI），在这些切片中将采用这些客观的定量测量方法。 第一组客观量化措施是描述分配给图像切片ROI内的像素的所有灰度级发生频率的一阶纹理度量。 第二组客观的量化措施是表征ROI的特定像素之间的空间相互依赖性的二阶纹理度量。 还可以进行分形分析，以提供投资回报率的额外目标，定量测量。 基于获得的一阶或二阶纹理测量和分形测量的最佳子集，将ROI归类为特定的组织病理学类别。 显示颜色编码的输出，用于向用户呈现指示分配给CT切片的不同区域的不同组织病理学类别的用户。
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公开(公告)号：US20080134213A1
公开(公告)日：2008-06-05
申请号：US11857261
申请日：2007-09-18
申请人： Gail A. Alverson , Robert L. Alverson , Daniel C. Duval , Eric A. Hoffman , Laurence S. Kaplan , Matthew Kelly , Kazuya Okubo , Mark Swan , Asaph Zemach
发明人： Gail A. Alverson , Robert L. Alverson , Daniel C. Duval , Eric A. Hoffman , Laurence S. Kaplan , Matthew Kelly , Kazuya Okubo , Mark Swan , Asaph Zemach
IPC分类号： G06F13/00
CPC分类号： G06F11/0781 , G06F11/0709 , G06F11/3048 , G06F11/3072
摘要： An availability system is provided that includes a hierarchy of controllers for providing event notifications relating to availability of components of a scalable MPP system. A controller receives a subscription from a child controller that identifies an event type and a generator. The controller stores in a subscription store an indication that the subscription has been received from the child controller. When a parent controller has not yet been notified of a subscription with a matching event type and generator as indicated by the subscription store, the controller sends the subscription to the parent controller. When the parent controller has already been notified of a subscription with a matching event type and generator as indicated by the subscription store, the controller suppresses the sending of the subscription to the parent controller.
摘要翻译： 提供了一种可用性系统，其包括用于提供与可伸缩MPP系统的组件的可用性相关的事件通知的控制器层级。 控制器接收来自识别事件类型和发生器的子控制器的订阅。 控制器在订阅存储器中存储已经从子控制器接收到订阅的指示。 当父控制器尚未被通知订阅存储器所指示的匹配事件类型和生成器的订阅时，控制器将该订阅发送给父控制器。 当父控制器已被通知具有由订阅存储所指示的匹配事件类型和生成器的订阅时，控制器禁止向父控制器发送订阅。
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公开(公告)号：US07984453B2
公开(公告)日：2011-07-19
申请号：US11857261
申请日：2007-09-18
申请人： Gail A. Alverson , Robert L. Alverson , Daniel C. Duval , Eric A. Hoffman , Laurence S. Kaplan , Matthew Kelly , Kazuya Okubo , Mark Swan , Asaph Zemach
发明人： Gail A. Alverson , Robert L. Alverson , Daniel C. Duval , Eric A. Hoffman , Laurence S. Kaplan , Matthew Kelly , Kazuya Okubo , Mark Swan , Asaph Zemach
CPC分类号： G06F11/0781 , G06F11/0709 , G06F11/3048 , G06F11/3072
摘要： An availability system is provided that includes a hierarchy of controllers for providing event notifications relating to availability of components of a scalable MPP system. A controller receives a subscription from a child controller that identifies an event type and a generator. The controller stores in a subscription store an indication that the subscription has been received from the child controller. When a parent controller has not yet been notified of a subscription with a matching event type and generator as indicated by the subscription store, the controller sends the subscription to the parent controller. When the parent controller has already been notified of a subscription with a matching event type and generator as indicated by the subscription store, the controller suppresses the sending of the subscription to the parent controller.
摘要翻译： 提供了一种可用性系统，其包括用于提供与可伸缩MPP系统的组件的可用性相关的事件通知的控制器层级。 控制器接收来自识别事件类型和发生器的子控制器的订阅。 控制器在订阅存储器中存储已经从子控制器接收到订阅的指示。 当父控制器尚未被通知订阅存储器所指示的匹配事件类型和生成器的订阅时，控制器将该订阅发送给父控制器。 当父控制器已被通知具有由订阅存储所指示的匹配事件类型和生成器的订阅时，控制器禁止向父控制器发送订阅。
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公开(公告)号：US07885438B2
公开(公告)日：2011-02-08
申请号：US10251446
申请日：2002-09-20
IPC分类号： G06K9/00
CPC分类号： G06T7/0012
摘要： A method for automated analysis of textural differences present on an image volume. The image volume includes a plurality of volume elements, and each volume element has a gray level. The method includes defining a volume of interest (VOI); performing texture measures within the VOI; and classifying the VOI as belonging to a tissue pathology class based upon the texture measures. Computer readable media encoded with computer readable instructions for carrying out these functions. An apparatus that includes an image input adapted to receive a diagnostic medical image. The image includes a plurality of pixels, and each pixel has a particular gray level. The apparatus also includes a display for displaying a graphical user interface and the received image; and a processor adapted to perform texture measures on one or more groups of pixels within the image and classify each group of pixels to a tissue pathology class based upon the textures measures. The processor is further adapted to (1) associate a color to each group of pixels indicative of the group's tissue pathology class, (2) cause the display to display one or more of the colors on the image at the location of the associated group or groups of pixels, (3) permit a user to manually associate a tissue pathology class to a group of pixels, and (4) cause the display to display the manually-associated tissue pathology class.
摘要翻译： 用于自动分析图像体积上存在的纹理差异的方法。 图像体积包括多个体积元素，并且每个体积元素具有灰度级。 该方法包括定义感兴趣体积（VOI）; 在VOI内执行纹理测量; 并且基于纹理测量将VOI分类为属于组织病理学类别。 用计算机可读指令编码的用于执行这些功能的计算机可读介质。 一种包括适于接收诊断医学图像的图像输入的装置。 图像包括多个像素，并且每个像素具有特定的灰度级。 该装置还包括用于显示图形用户界面和接收到的图像的显示器; 以及处理器，其适于在所述图像内的一个或多个像素组上执行纹理测量，并且基于所述纹理测量将每组像素分类到组织病理类别。 处理器还适于（1）将颜色与指示组的组织病理类别的每组像素相关联，（2）使得显示器在相关联的组的位置处的图像上显示一种或多种颜色，或 （3）允许用户将组织病理学类别手动地关联到一组像素，以及（4）使显示器显示手动相关的组织病理学类。
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公开(公告)号：US5183038A
公开(公告)日：1993-02-02
申请号：US787510
申请日：1991-11-04
CPC分类号： A61M1/10 , A61M16/00 , A61M16/0009 , A61M2016/0036 , A61M2230/04
摘要： A ventiltor for ventilating the lungs of a patient is described as including a valve member connected to a fluid source and to the patient. The valve member controls the flow of fluid to the patient in response to a control signal. A programmable controller, connected to the valve member, generates the control signal for the valve member. The programmable controller includes a memory in which fluid flow rate information has been stored and a microprocessor. The controller is operative to determine a desired fluid flow rate in relation to the flow rate information and for generating the control signal in relation to the flow rate signal. In a preferred embodiment the valve member includes a plurality of first and second valves, wherein each of the second valves are operative to allow fluid to pass therethrough at flow rates which are multiples of a master flow rate. It is especially preferred for the multiple for each second valve to be equal to the value 2.sup.M, where M is an integer from zero to one less than the number of second valves. If the memory further has stored therein pressure information it is desireable to include a first monitor for generating a heart signal, a second monitor for generating a lung flow rate and a third monitor for generating a lung pressure signal. In such a situation it is preferred for the controller to be connected to receive the heart signal, the flow rate signal and the pressure signal, and for the control signal to be generated in response to such signals.
摘要翻译： 用于使患者的肺通气的透气器被描述为包括连接到流体源和患者的阀构件。 阀构件响应于控制信号控制流体到患者的流动。 连接到阀构件的可编程控制器产生阀构件的控制信号。 可编程控制器包括其中存储有流体流量信息的存储器和微处理器。 控制器用于确定与流量信息相关的期望流体流速并且用于相对于流量信号产生控制信号。 在优选实施例中，阀构件包括多个第一和第二阀，其中每个第二阀可操作以允许流体以以主流量的倍数的流速通过。 特别优选的是，每个第二阀的倍数等于值2M，其中M是从零到小于第二阀的数量的整数。 如果存储器还存储有压力信息，则期望包括用于产生心脏信号的第一监视器，用于产生肺流量的第二监视器和用于产生肺压力信号的第三监视器。 在这种情况下，优选的是控制器被连接以接收心脏信号，流量信号和压力信号，并且响应于这种信号而产生控制信号。
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公开(公告)号：US5188098A
公开(公告)日：1993-02-23
申请号：US787635
申请日：1991-11-04
IPC分类号： A61M16/00
CPC分类号： A61M16/00 , A61M2016/0021 , A61M2230/04
摘要： Method and apparatus for maximizing the volume of blood pumped by a heart and maximizing ventilation/perfusion matching in the lungs, wherein the lungs are ventilated by a respirator in response to a control signal, are shown to include a series of monitors for generating a heart signal such as an electrocardiogram, a lung air flow rate signal and a lung air pressure signal and a controller, connected to receive these signals and to the respirator. The controller monitors the signals and generates the control signal when the heart signal is representative of a desired in point in the pumping cycle of the heart and the other signals indicate desired flow rate and pressure in the lungs. In a preferred embodiment, the control signal is generated so as to maximize the augmentation of the pumping of the heart and to minimize the trapping of air in the lungs. Using the present invention, blood being pumped from the heart is assisted by the ventilation of the lungs. It is preferred for the controller to include a series of threshold detectors for detecting when the signals exceed threshold levels. It is especially preferred for the detector to detect a point during ventricular contraction. It is especially preferred for the apparatus to further include a delay mechanism, interposed between the respirator and the controller, for delaying the control signal.
摘要翻译： 用于使由心脏泵送的血液的体积最大化并且使肺中的通气/灌注匹配最大化的方法和装置，其中响应于控制信号，肺通过呼吸器通气，显示包括用于产生心脏的一系列监护仪 信号，例如心电图，肺空气流量信号和肺气压信号和控制器，连接以接收这些信号和呼吸器。 当心脏信号代表心脏的泵送周期中期望的点时，控制器监测信号并产生控制信号，而其它信号表示肺中所需的流速和压力。 在优选实施例中，生成控制信号以使心脏的泵送增加最大化并且使肺中空气的捕获最小化。 使用本发明，通过肺的通气辅助从心脏泵送的血液。 优选地，控制器包括一系列阈值检测器，用于检测何时信号超过阈值电平。 检测器特别优选在心室收缩期间检测点。 特别优选的是，该装置还包括延迟机构，介于呼吸器和控制器之间，用于延迟控制信号。
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