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1.发明申请公开(公告)号：US20180140861A1
公开(公告)日：2018-05-24
申请号：US15674276
申请日：2017-08-10
CPC分类号： A61N2/02 , A41D13/1245 , A41D2400/32 , A42B1/242 , A47G9/00 , A47G9/10 , A61N1/0484 , A61N1/40
摘要： Pulsed electromagnetic field (PEMF) apparatuses and methods of making and using them. In particular, described herein are two-part PEMF apparatuses that include a self-contained, lightweight, small, compact (e.g., in some variations, wearable) generator unit that is adapted to releasably and replaceably mate with an applicator unit. The generator unit typically includes a power source and a controller that generated PEMF waveforms to be applied, including the shape and timing of the PEMF waveforms. The applicator unit typically includes a radio frequency (RF) power amplifier, a loop antenna, and impedance matching circuitry for matching the impedances for the connection between the antenna loop and the RF power amplifier. Thus, the generator module may control the application of PEMF signals without requiring impedance matching between the separable generator unit and the applicator unit. The applicator unit can include a plurality of variable capacitors that can be used to tune the PEMF signals.
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2.发明申请公开(公告)号：US20200044318A1
公开(公告)日：2020-02-06
申请号：US16485428
申请日：2018-02-23
摘要： Systems for converting personal communications devices (e.g., smart phones) into devices for directly or wirelessly delivering either the native RF communications EMF signal or shaped and calibrated electromagnetic signals to promote cell and tissue growth, repair, and maintenance in plants, animals and humans which can modulate biochemical signaling pathways. In particular, described herein are systems, devices and methods for converting mobile communications devices (including PDAs, cell phones, mobile phones, etc.) to provide therapeutically-relevant EMF therapy (e.g., PEMF therapy), as well as methods of treating a patient using personal communications devices (PCDs) running an application for the delivery and monitoring of EMF therapy to a patient from the PCD.
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公开(公告)号：US10426967B2
公开(公告)日：2019-10-01
申请号：US15217855
申请日：2016-07-22
摘要： Described herein are methods of treating neurological injury and conditions, in particular symptoms and complications arising from or caused by a stroke. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source and applying the pulsed electromagnetic field in proximity to a target region.
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公开(公告)号：US10350428B2
公开(公告)日：2019-07-16
申请号：US14932928
申请日：2015-11-04
发明人： Arthur A. Pilla
摘要： Embodiments of the invention include methods of treating a patient with physiological responses arising from an injury or condition, such as post-operative pain, traumatic brain injury, and cognitive defects. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source which is configured to simultaneously increase the rate of ion-dependent signaling, such as CaM/NO/cGMP signaling and to minimize the rate of inhibition of such signaling by natural compounds and applying the pulsed electromagnetic field in proximity to a target region affected by the injury or condition for a first treatment interval followed by an inter-treatment period with no electromagnetic field between treatment intervals to reduce a physiological response to the injury or condition.
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公开(公告)号：US10207122B2
公开(公告)日：2019-02-19
申请号：US14687716
申请日：2015-04-15
发明人： Arthur A. Pilla
摘要： Apparatus and methods for delivering electromagnetic signals configured specifically to accelerate the asymmetrical kinetics of the binding of intracellular ions to their respective intracellular buffers, to enhance the biochemical signaling pathways plant animal and human molecules, cells, tissues, organs, portions of entire organisms and entire organisms employ for growth, repair and maintenance. Described herein are devices and methods that utilize repetitive bursts of waveforms configured to maximize the bound concentration of intracellular ions at their associated molecular buffers to enhance the biochemical signaling pathways living systems employ for growth, repair and maintenance. For example the systems and methods described herein may drive the binding of calcium to calmodulin (CaM), thereby enhancing the CaM-dependent nitric oxide (NO)/cyclic guanosine monophosphate (cGMP) signaling pathway.
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6.发明申请公开(公告)号：US20200094068A1
公开(公告)日：2020-03-26
申请号：US16657827
申请日：2019-10-18
摘要： A method for controlling levels of glucose and lipids in the blood of a patient having non-alcoholic steatohepatitis (NASH) includes generating an electromagnetic signal and coupling the electromagnetic signal to a target structure in the patient's liver to a induce a pulsed magnetic field in the target structure. The signal may include bursts of sinusoidal, rectangular, chaotic, and/or random waveforms, having a frequency content in a range of about 0.01 Hz to about 100 MHz at about 1 to about 100,000 waveforms per second, a burst duration from about 1 μsec to about 100 msec, a burst repetition rate from about 0.01 to about 1000 bursts/second. The induced magnetic field may have a peak amplitude of between 2 and 20 μT. The treatment may be repeated between 1 and 3 times per day every day for at least one week.
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公开(公告)号：US10556121B2
公开(公告)日：2020-02-11
申请号：US15549748
申请日：2016-02-22
发明人： Blake Taylor Gurfein
摘要： Methods and apparatuses (including systems, devices, etc.) for the treatment of neurological disorders, and particularly multiple sclerosis (MS) by the application of electromagnetic fields (EMF), and in particular, pulsed electromagnetic fields (PEMF), including a subset of PEMF in a radio frequency domain (e.g., pulse-modulated radio frequency or PRF). This treatment may prevent or delay the onset, and/or may reduce the severity of the onset of MS and MS-related symptoms.
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公开(公告)号：US20190351249A1
公开(公告)日：2019-11-21
申请号：US16431561
申请日：2019-06-04
发明人： Arthur A Pilla
IPC分类号： A61N2/00
摘要： Embodiments of the invention include methods of treating a patient with physiological responses arising from an injury or condition, such as post-operative pain, traumatic brain injury, and cognitive defects. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source which is configured to simultaneously increase the rate of ion-dependent signaling, such as CaM/NO/cGMP signaling and to minimize the rate of inhibition of such signaling by natural compounds and applying the pulsed electromagnetic field in proximity to a target region affected by the injury or condition for a first treatment interval followed by an inter-treatment period with no electromagnetic field between treatment intervals to reduce a physiological response to the injury or condition.
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9.发明授权公开(公告)号：US10226640B2
公开(公告)日：2019-03-12
申请号：US14608140
申请日：2015-01-28
摘要： Described herein are devices and methods for treating degenerative joint diseases with electromagnetic fields using one or more waveforms that are configured to modulate Ca2+ binding to calmodulin and thereby modulate calmodulin-dependent nitric oxide signaling within joint and other affected tissue for the purpose of reducing pain and inflammation, as well as enhancing the healing and regeneration of such tissue.
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公开(公告)号：US20180200531A1
公开(公告)日：2018-07-19
申请号：US15920248
申请日：2018-03-13
发明人： Arthur A. Pilla
摘要： Embodiments of the invention include methods of treating a patient with physiological responses arising from an injury or condition, such as post-operative pain, traumatic brain injury, and cognitive defects. These treatment methods can include the steps of generating a pulsed electromagnetic field from a pulsed electromagnetic field source which is configured to simultaneously increase the rate of ion-dependent signaling, such as CaM/NO/cGMP signaling and to minimize the rate of inhibition of such signaling by natural compounds and applying the pulsed electromagnetic field in proximity to a target region affected by the injury or condition for a first treatment interval followed by an inter-treatment period with no electromagnetic field between treatment intervals to reduce a physiological response to the injury or condition.
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