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1.发明授权Intraoral dosing method of administering trifluorobenzodiazepines, propoxyphene, and nefazodone 失效三氟苯二氮卓，丙氧芬和奈法唑酮的口服给药方法
公开(公告)号：US5504086A
公开(公告)日：1996-04-02
申请号：US321246
申请日：1994-10-11
Applicant: Everett H. Ellinwood, Jr. , Samir K. Gupta
Inventor： Everett H. Ellinwood, Jr. , Samir K. Gupta
IPC: A61K31/137 , A61K31/222 , A61K31/496 , A61K31/5513 , A61K31/495 , A61K31/50
CPC classification number: A61K31/496 , A61K31/137 , A61K31/222 , A61K31/5513
Abstract: A method of therapeutically administering certain BZ.sub.1 specific trifluorobenzodiazepines in order to maximize the BZ.sub.1 effects and minimize the BZ.sub.2 effects on the human central nervous system in order to maximize the anti-anxiety, anticonvulsant and hypnotic effects and minimize the ataxic and incoordination effects of the drug. Also, a method of sublingual administration of trifluorobenzodiazepines and certain other compounds, such as propoxyphene and nefazodone, in order to decrease unwanted metabolites.
Abstract translation: 一种治疗性施用某些BZ1特异性三氟苯并二氮杂卓的方法，以使BZ1效应最大化并使BZ2对人中枢神经系统的作用最小化，以最大化抗焦虑，抗惊厥和催眠作用，并使药物的共济失调和不协调作用最小化 。 另外，一种舌下给予三氟苯并二氮杂类物质和某些其它化合物如丙氧芬和奈法唑酮的方法，以减少不必要的代谢物。
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公开(公告)号：US5739136A
公开(公告)日：1998-04-14
申请号：US622829
申请日：1996-03-27
Applicant: Everett H. Ellinwood, Jr. , Samir K. Gupta
Inventor： Everett H. Ellinwood, Jr. , Samir K. Gupta
IPC: A61K31/137 , A61K31/496 , A61K31/5513 , A61K31/495
CPC classification number: A61K31/5513 , A61K31/137 , A61K31/496
Abstract: A method of therapeutically administering certain medicaments in order to maximize the desired effects and minimize the unwanted metabolite effects on the human body, including the central nervous system, in order to maximize therapeutic effects, such as anti-anxiety, anticonvulsant and hypnotic effects, and minimize unwanted side effects, such as ataxic and incoordination effects, of the drug. Also, a method of sublingual or buccal administration of certain medicaments in order to decrease metabolism of the medicaments to unwanted metabolites.
Abstract translation: 治疗性施用某些药物的方法是为了最大化期望的效果并最小化对包括中枢神经系统在内的人体的不希望的代谢物作用，以最大限度地发挥治疗效果，例如抗焦虑，抗惊厥和催眠作用，以及 减少药物不希望有的副作用，如共济失调和不协调的影响。 而且，一种舌下或口腔给药某些药物的方法，以便将药物的代谢降低到不想要的代谢物。
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公开(公告)号：US4003379A
公开(公告)日：1977-01-18
申请号：US616294
申请日：1975-09-24
Applicant: Everett H. Ellinwood, Jr.
Inventor： Everett H. Ellinwood, Jr.
CPC classification number: A61M5/14276 , A61B5/0468 , A61B5/14532 , A61M5/14244 , A61M5/1723 , A61M2205/3507 , A61N5/1001 , Y10S128/01
Abstract: An apparatus for dispensing drugs and other medications within the body leaves the patient ambulatory and is adapted to be entirely implanted and to dispense such substances over a long period of time, e.g., one to several years, in accordance with the actual needs of the patient. A self-powered dispensing device stores a single or plural substances in powdered, liquid, or other dispensable form and utilizes a compressible container, i.e., a bellows, for withdrawing such substances from storage and dispensing to the body. The dispensing operation may be on a fixed schedule or may be controlled by monitoring single or plural sensors implanted in the body and evaluating the sensed data in order to control both the conditions under which and the kind of dispensing which takes place. Dual dispensers and dual medication may be employed.
Abstract translation: 用于在体内分配药物和其他药物的装置使患者走动，并且适于完全植入并根据患者的实际需要长时间（例如一至几年）分配这些物质 。 自动供电装置将单一或多种物质以粉末，液体或其它可分配形式储存，并且利用可压缩的容器即波纹管将这些物质从存储和分配中取出到身体。 分配操作可以是固定的时间表，或者可以通过监测植入在身体中的单个或多个传感器来评估感测数据来控制，以便控制发生的分配条件和种类。 可以使用双重分配器和双重药物。
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Patent Agency Ranking
公开(公告)号：US6048857A
公开(公告)日：2000-04-11
申请号：US9678
申请日：1998-01-20
Applicant: Everett H. Ellinwood, Jr. , Samir K. Gupta
Inventor： Everett H. Ellinwood, Jr. , Samir K. Gupta
IPC: A61K31/55
CPC classification number: A61K31/137 , A61K31/496 , A61K31/5513
Abstract: A method of therapeutically administering certain medicaments in order to maximize the desired effects and minimize the unwanted metabolite effects on the human body, including the central nervous system, in order to maximize therapeutic effects, such as anti-anxiety, anticonvulsant and hypnotic effects, and minimize unwanted side effects, such as ataxic and incoordination effects, of the medicament. Also, a method of inhalation administration or skin administration of certain medicaments in order to decrease metabolism of the medicaments to unwanted metabolites.
Abstract translation: 治疗性施用某些药物的方法是为了最大化期望的效果并最小化对包括中枢神经系统在内的人体的不希望的代谢物作用，以最大限度地发挥治疗效果，例如抗焦虑，抗惊厥和催眠作用，以及 最小化药物的不希望的副作用，如共济失调和不协调的作用。 此外，吸入给药或某些药物的皮肤给药方法是为了将药物的代谢降低为不需要的代谢物。
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5.发明授权Dosing method of administering medicaments via inhalation administration or skin administration 失效通过吸入给药或皮肤给药施用药物的给药方法
公开(公告)号：US6140323A
公开(公告)日：2000-10-31
申请号：US436676
申请日：1999-11-09
Applicant: Everett H. Ellinwood, Jr. , Samir K. Gupta
Inventor： Everett H. Ellinwood, Jr. , Samir K. Gupta
IPC: A61K31/55
CPC classification number: A61K31/137 , A61K31/496 , A61K31/5513
Abstract: A method of therapeutically administering certain medicaments in order to maximize the desired effects and minimize the unwanted metabolite effects on the human body, including the central nervous system, in order to maximize therapeutic effects, such as anti-anxiety, anticonvulsant and hypnotic effects, and minimize unwanted side effects, such as ataxic and incoordination effects, of the medicament. Also, a method of inhalation administration or skin administration of certain medicaments in order to decrease metabolism of the medicaments to unwanted metabolites.
Abstract translation: 治疗性施用某些药物的方法是为了最大化期望的效果并最小化对包括中枢神经系统在内的人体的不希望的代谢物作用，以最大限度地发挥治疗效果，例如抗焦虑，抗惊厥和催眠作用，以及 最小化药物的不希望的副作用，如共济失调和不协调的作用。 此外，吸入给药或某些药物的皮肤给药方法是为了将药物的代谢降低为不需要的代谢物。
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公开(公告)号：US5198436A
公开(公告)日：1993-03-30
申请号：US703049
申请日：1991-05-17
Applicant: Everett H. Ellinwood, Jr. , Samir K. Gupta
Inventor： Everett H. Ellinwood, Jr. , Samir K. Gupta
IPC: A61K31/137 , A61K31/496 , A61K31/55 , A61K31/5513
CPC classification number: A61K31/55 , A61K31/137 , A61K31/496 , A61K31/5513
Abstract: A method of therapeutically administering certain BZ.sub.1 specific trifluorobenzodiazepines in order to maximize the BZ.sub.1 effects and minimize the BZ.sub.2 effects on the human central nervous system in order to maximize the anti-anxiety, anticonvulsant and hypnotic effects and minimize the ataxic and incoordination effects of the drug.
Abstract translation: 一种治疗性施用某些BZ1特异性三氟苯并二氮杂卓的方法，以使BZ1效应最大化并使BZ2对人中枢神经系统的作用最小化，以最大化抗焦虑，抗惊厥和催眠作用，并使药物的共济失调和不协调作用最小化 。
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公开(公告)号：US4146029A
公开(公告)日：1979-03-27
申请号：US802118
申请日：1977-05-31
Applicant: Everett H. Ellinwood, Jr.
Inventor： Everett H. Ellinwood, Jr.
CPC classification number: A61N1/37211 , A61B5/0468 , A61B5/14532 , A61M5/14276 , A61M5/1723 , A61M2205/3507 , A61N1/37264 , A61N5/1001 , Y10S128/903
Abstract: A device and method for dispensing medication internally of the body utilize an implanted system which includes medication storage and dispensing control circuitry having control components which may be modified by means external of the body being treated to control the manner of dispensing the medication within such body. Coordinated pacemaking is also available.
Abstract translation: 用于在身体内部分配药物的装置和方法利用植入系统，其包括具有控制部件的药物储存和分配控制电路，所述控制部件可以通过被处理的身体的外部装置进行修改，以控制在该体内分配药物的方式。 协调的起搏也可用。
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公开(公告)号：US3692027A
公开(公告)日：1972-09-19
申请号：US3692027D
申请日：1971-04-23
Applicant: EVERETT H ELLINWOOD JR
Inventor： ELLINWOOD EVERETT H JR
CPC classification number: A61M5/14276
Abstract: A self-micro-powered implanted device contains a store of medicine in powdered, liquid or other dispensable form and which is gradually discharged incrementally over a substantially long period of time.
Abstract translation: 自体动力植入装置包含粉末状，液体状或其它可分配形式的药物储存体，并且在相当长的一段时间内逐渐逐渐排出。
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