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1.发明授权Knitting needle having anchoring means for a filler held in the needle shank 失效编织针具有用于保持在针柄中的填料的锚固装置
公开(公告)号：US5582038A
公开(公告)日：1996-12-10
申请号：US566124
申请日：1995-12-01
申请人： Erich Braun , Albert Teufel
发明人： Erich Braun , Albert Teufel
IPC分类号： D04B35/02
CPC分类号： D04B35/02
摘要： A stamped knitting tool includes a shank and a window which is provided in the shank and which is bounded by a surrounding window-framing edge of the shank. Along at least a length portion of the window-framing edge a chamfer is provided which borders the window. A heterogenous material fills the window and is fixedly connected with the shank. The chamfer projects into the heterogenous material.
摘要翻译： 冲压针织工具包括柄和窗，其设置在柄中并且由柄的周围的窗框边缘限定。 沿着窗框边缘的至少长度部分，提供了与窗口相邻的倒角。 异质材料填充窗口并与柄固定连接。 倒角投入异质材料。
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公开(公告)号：US1729204A
公开(公告)日：1929-09-24
申请号：US18652427
申请日：1927-04-25
申请人： ERICH BRAUN
发明人： ERICH BRAUN
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3.发明授权Heat shock protein peptides and methods for modulating autoimmune central nervous system disease 失效热休克蛋白肽和调节自身免疫性中枢神经系统疾病的方法
公开(公告)号：US5958416A
公开(公告)日：1999-09-28
申请号：US447154
申请日：1995-05-23
CPC分类号： C07K14/35 , C07K14/4713 , C12N9/16 , A61K38/00 , Y10S514/885 , Y10S514/903
摘要： The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. One class of peptides are antigens derived from mycobacterial heat shock proteins and may immunologically cross-react with or are homologous to myelin components. The peptides can also be derived from myelin components such as 2',3' cyclic nucleotide phosphodiesterase and immunologically cross-react with and/or are homologous to mycobacterial heat shock proteins. A method of the invention involves administering a pharmaceutical composition including at least one peptide to an animal in an amount effective to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are useful for the prevention, and treatment of autoimmune inflammatory central nervous system disease.
摘要翻译： 本发明提供了使用肽阻断或抑制对中枢神经系统组分的致病性自身免疫应答的肽和方法。 一类肽是来自分枝杆菌热休克蛋白的抗原，可与髓磷脂成分免疫交叉反应或与其同源。 肽还可以衍生自髓鞘组分如2'，3'环核苷酸磷酸二酯酶，并与分枝杆菌热休克蛋白免疫交叉反应和/或同源。 本发明的方法包括向动物施用包含至少一种肽的药物组合物，其量可有效阻断或抑制对中枢神经系统组分的致病性自身免疫应答。 该肽可用于预防和治疗自身免疫性中枢神经系统疾病。
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4.发明授权Heat shock protein peptides that share sequences with cyclic nucleotide phosphodiesterase and methods for modulating autoimmune central nervous system disease 失效与环状核苷酸磷酸二酯酶共享序列的热休克蛋白肽和调节自身免疫性中枢神经系统疾病的方法
公开(公告)号：US5874405A
公开(公告)日：1999-02-23
申请号：US368834
申请日：1994-12-16
CPC分类号： C07K14/35 , C07K14/4713 , C12N9/16 , A61K38/00
摘要： The invention provides for peptides and methods of using peptides to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are antigens derived from mycobacterial heat shock proteins and that immunologically crossreact with or are homologous to myelin components. The peptides can also be derived from myelin components such as 2',3' cyclic nucleotide phosphodiesterase and that immunologically crossreact and/or are homologous to mycobacterial heat shock proteins. A method of the invention involves administering a pharmaceutical composition including at least one peptide to an animal in an amount effective to block or inhibit a pathogenic autoimmune response to central nervous system components. The peptides are useful for the prevention, and treatment of autoimmune inflammatory central nervous system disease.
摘要翻译： 本发明提供了使用肽阻断或抑制对中枢神经系统组分的致病性自身免疫应答的肽和方法。 肽是来自分枝杆菌热休克蛋白的抗原，并且与髓鞘成分免疫交叉或与髓鞘成分同源。 肽还可以衍生自髓鞘组分如2'，3'环核苷酸磷酸二酯酶，并且与免疫交叉反应和/或与分枝杆菌热休克蛋白同源。 本发明的方法包括向动物施用包含至少一种肽的药物组合物，其量可有效阻断或抑制对中枢神经系统组分的致病性自身免疫应答。 该肽可用于预防和治疗自身免疫性中枢神经系统疾病。
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