公开(公告)号：US06344571B2

公开(公告)日：2002-02-05

申请号：US09788344

申请日：2001-02-21

Applicant: Peter H. G. Wiegerinck ,  Duncan Sperling ,  Lesly Braamer ,  Eric W. P. Damen ,  Johan W. Scheeren ,  Dick de Vos

Inventor： Peter H. G. Wiegerinck ,  Duncan Sperling ,  Lesly Braamer ,  Eric W. P. Damen ,  Johan W. Scheeren ,  Dick de Vos

IPC: C07D30514

CPC classification number: C07D305/14

Abstract: The invention relates to water soluble antitumor analogs of paclitaxel of formula (I) wherein R1=C(O)CH2CH(OH)COOX, R2=H, C(O)CH2CH(OH)COOX, X=H, Li, Na or any other pharmaceutically acceptable counterion, as well as to a pharmaceutical composition comprising an antineoplastically effective amount of such analogs as an active ingredient.

Abstract translation: 本发明涉及式（I）的紫杉醇的水溶性抗肿瘤类似物，其中R1 = C（O）CH2CH（OH）COOX，R2 = H，C（O）CH2CH（OH）COOX，X = H，Li，Na或 任何其它药学上可接受的抗衡离子，以及包含抗肿瘤有效量的这些类似物作为活性成分的药物组合物。