公开(公告)号：US09029385B2

公开(公告)日：2015-05-12

申请号：US12739934

申请日：2008-10-23

申请人： Ganesh Raghu ,  Douglas Harry Unwin ,  Lola Maksumova

发明人： Ganesh Raghu ,  Douglas Harry Unwin ,  Lola Maksumova

IPC分类号： A61K31/522 ,  A61K31/198 ,  A61P1/16 ,  A61P9/00 ,  A61K45/06

CPC分类号： A61K45/06 ,  A61K31/198 ,  A61K31/522 ,  A61K2300/00

摘要： The present invention relates, in general, to fibroproliferative disorders, and, in particular, to methods and compositions for treating fibroproliferative disorders by administering to a mammal in need of treatment pharmacologically effective doses of a phosphodiesterase inhibitor, such as pentoxifylline, and an anti-oxidant which is a precursor of glutathione, such as N-acetyl-cysteine, or their derivatives or metabolites.

摘要翻译： 本发明一般涉及纤维增生性疾病，特别涉及通过向需要治疗的哺乳动物施用治疗药理学有效剂量的磷酸二酯酶抑制剂如己酮可可碱和抗 - 氧化剂，其是谷胱甘肽的前体，例如N-乙酰基半胱氨酸或其衍生物或代谢物。

公开(公告)号：US20110009431A1

公开(公告)日：2011-01-13

申请号：US12739934

申请日：2008-10-23

申请人： Raghu Ganesh ,  Douglas Harry Unwin ,  Lola Maksumova

发明人： Raghu Ganesh ,  Douglas Harry Unwin ,  Lola Maksumova

IPC分类号： A61K31/522 ,  A61K31/198 ,  A61P1/16 ,  A61P9/00

CPC分类号： A61K45/06 ,  A61K31/198 ,  A61K31/522 ,  A61K2300/00

摘要： The present invention relates, in general, to fibroproliferative disorders, and, in particular, to methods and compositions for treating fibroproliferative disorders by administering to a mammal in need of treatment pharmacologically effective doses of a phosphodiesterase inhibitor, such as pentoxifylline, and an anti-oxidant which is a precursor of glutathione, such as N-acetyl-cysteine, or their derivatives or metabolites.

摘要翻译： 本发明一般涉及纤维增生性疾病，特别涉及通过向需要治疗的哺乳动物施用治疗药理学有效剂量的磷酸二酯酶抑制剂如己酮可可碱和抗 - 氧化剂，其是谷胱甘肽的前体，例如N-乙酰基半胱氨酸或其衍生物或代谢物。

公开(公告)号：US20110288134A1

公开(公告)日：2011-11-24

申请号：US13126887

申请日：2009-10-28

申请人： Lola Maksumova ,  Douglas Harry Unwin

发明人： Lola Maksumova ,  Douglas Harry Unwin

IPC分类号： A61K31/198 ,  A61K31/4418 ,  A61P15/00 ,  A61P1/16 ,  A61P13/12 ,  A61P9/00 ,  A61K31/196 ,  A61P11/00

CPC分类号： A61K45/06 ,  A61K31/196 ,  A61K31/198 ,  A61K31/4415 ,  A61K2300/00

摘要： The present invention relates, in general, to fibroproliferative disorders, and, in particular, to a method of treating, preventing or reducing fibroproliferative disorders by administering to a mammal in need a composition comprising pharmacologically effective doses of a cytokine modifier, such as tranilast or pirfenidone, and an anti-oxidant which is a precursor of glutathione, such as N-acetyl-cysteine, or their pharmaceutically acceptable derivatives, salts, metabolites, or structural or functional analogues thereof.

摘要翻译： 本发明一般涉及纤维增生性疾病，特别涉及通过向需要的哺乳动物施用包含药理学有效剂量的细胞因子调节剂如曲尼司特或曲妥珠单抗的组合来治疗，预防或减少纤维增生性疾病的方法。 吡非尼酮和作为谷胱甘肽前体的抗氧化剂，例如N-乙酰半胱氨酸或其药学上可接受的衍生物，盐，代谢物或其结构或功能类似物。