公开(公告)号：US20100150423A1

公开(公告)日：2010-06-17

申请号：US12316497

申请日：2008-12-12

申请人： Dihui Hong ,  Avrum I. Cohen

发明人： Dihui Hong ,  Avrum I. Cohen

IPC分类号： G06K9/00

CPC分类号： G06K9/0014 ,  G06K9/342 ,  G06K9/48

摘要： Methods and systems for counting nuclei for cells in a cell-containing sample are disclosed, such as carried out on a computer. The methods comprise: receiving a raw image of the cell-containing sample; transforming the raw image into a segmented image comprising one or more nuclei clusters. The methods further comprise: for each of the one or more nuclei clusters, obtaining a convex hull of the nuclei cluster; locating any indentations on the nuclei cluster by comparing the nuclei cluster to the convex hull of the nuclei cluster; calculating a first nuclei count based on a tally of the indentations; and assigning the nuclei cluster to a cell among the plurality of cells. The methods further comprise: calculating a second nuclei count for each cell by totaling the first nuclei counts of its constituent nuclei clusters; and presenting a result based on the second nuclei count for at least one of the plurality of cells.

摘要翻译： 公开了用于计数含细胞样品中的细胞核的方法和系统，例如在计算机上进行的。 所述方法包括：接收含细胞样品的原始图像; 将原始图像转换成包括一个或多个核簇的分割图像。 所述方法还包括：对于所述一个或多个核簇中的每一个，获得所述核簇的凸包; 通过将核簇与核簇的凸包进行比较来确定核簇上的任何缺陷; 基于压痕的计数计算第一核计数; 以及将所述核簇分配给所述多个小区中的小区。 所述方法还包括：通过总计其组成核簇的第一核计数来计算每个细胞的第二核计数; 以及基于所述多个单元中的至少一个单元的第二核计数呈现结果。

公开(公告)号：US20130044940A1

公开(公告)日：2013-02-21

申请号：US13209992

申请日：2011-08-15

申请人： Avrum Cohen ,  Dihui Hong

发明人： Avrum Cohen ,  Dihui Hong

IPC分类号： G06K9/46 ,  G06K9/00 ,  G06K9/48

CPC分类号： G06K9/00134 ,  G06K9/0014 ,  G06T7/11 ,  G06T7/12 ,  G06T7/136 ,  G06T7/187 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/20064 ,  G06T2207/20084 ,  G06T2207/20152

摘要： A computer-implemented system and method of processing a microscopy image are provided. A microscopy image is received, and a configuration for an image section that includes a portion of the microscopy image is determined. Multiple image sections are respectively assigned to multiple processing units, and the processing units respectively process the image sections in parallel. One or more objects are determined to be respectively present in the image sections, and the objects present in the image sections are measured to obtain object data associated with the objects.

摘要翻译： 提供了一种计算机实现的系统和处理显微镜图像的方法。 接收显微镜图像，并且确定包括显微镜图像的一部分的图像部分的配置。 多个图像部分分别分配给多个处理单元，并且处理单元分别并行地处理图像部分。 确定一个或多个对象分别存在于图像部分中，并且测量存在于图像部分中的对象以获得与对象相关联的对象数据。

公开(公告)号：US08175369B2

公开(公告)日：2012-05-08

申请号：US12316497

申请日：2008-12-12

申请人： Dihui Hong ,  Avrum I. Cohen

发明人： Dihui Hong ,  Avrum I. Cohen

IPC分类号： G06K9/00

CPC分类号： G06K9/0014 ,  G06K9/342 ,  G06K9/48

摘要： Methods and systems for counting nuclei for cells in a cell-containing sample are disclosed, such as carried out on a computer. The methods comprise: receiving a raw image of the cell-containing sample; transforming the raw image into a segmented image comprising one or more nuclei clusters. The methods further comprise: for each of the one or more nuclei clusters, obtaining a convex hull of the nuclei cluster; locating any indentations on the nuclei cluster by comparing the nuclei cluster to the convex hull of the nuclei cluster; calculating a first nuclei count based on a tally of the indentations; and assigning the nuclei cluster to a cell among the plurality of cells. The methods further comprise: calculating a second nuclei count for each cell by totaling the first nuclei counts of its constituent nuclei clusters; and presenting a result based on the second nuclei count for at least one of the plurality of cells.

摘要翻译： 公开了用于计数含细胞样品中的细胞核的方法和系统，例如在计算机上进行的。 所述方法包括：接收含细胞样品的原始图像; 将原始图像转换成包括一个或多个核簇的分割图像。 所述方法还包括：对于所述一个或多个核簇中的每一个，获得所述核簇的凸包; 通过将核簇与核簇的凸包进行比较来确定核簇上的任何缺陷; 基于压痕的计数计算第一核计数; 以及将所述核簇分配给所述多个小区中的小区。 所述方法还包括：通过总计其组成核簇的第一核计数来计算每个细胞的第二核计数; 以及基于所述多个单元中的至少一个单元的第二核计数呈现结果。

公开(公告)号：US08731278B2

公开(公告)日：2014-05-20

申请号：US13209992

申请日：2011-08-15

申请人： Avrum Cohen ,  Dihui Hong

发明人： Avrum Cohen ,  Dihui Hong

IPC分类号： G06K9/00

CPC分类号： G06K9/00134 ,  G06K9/0014 ,  G06T7/11 ,  G06T7/12 ,  G06T7/136 ,  G06T7/187 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/20064 ,  G06T2207/20084 ,  G06T2207/20152

摘要： A computer-implemented system and method of processing a microscopy image are provided. A microscopy image is received, and a configuration for an image section that includes a portion of the microscopy image is determined. Multiple image sections are respectively assigned to multiple processing units, and the processing units respectively process the image sections in parallel. One or more objects are determined to be respectively present in the image sections, and the objects present in the image sections are measured to obtain object data associated with the objects.

摘要翻译： 提供了一种计算机实现的系统和处理显微镜图像的方法。 接收显微镜图像，并且确定包括显微镜图像的一部分的图像部分的配置。 多个图像部分分别分配给多个处理单元，并且处理单元分别并行地处理图像部分。 确定一个或多个对象分别存在于图像部分中，并且测量存在于图像部分中的对象以获得与对象相关联的对象数据。

公开(公告)号：US08577079B2

公开(公告)日：2013-11-05

申请号：US13225021

申请日：2011-09-02

申请人： Avrum Isaac Cohen ,  Dihui Hong

发明人： Avrum Isaac Cohen ,  Dihui Hong

IPC分类号： G06K9/00

CPC分类号： G06K9/00134 ,  G06K9/6253 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/136 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/20081 ,  G06T2207/20152 ,  G06T2207/30024

摘要： A computer-implemented method of processing a selected image using multiple processing operations is provided. An image analysis sequence having multiple processing steps is constructed. The image analysis sequence is constructed in response to receipt of multiple processing operation selections. Individual processing steps in the image analysis sequence are associated with a processing operation that is indicated in a corresponding processing operation selection. The processing steps are arranged in response to receipt of arrangement information that relates to a selective arrangement of the processing steps. At least one of the processing steps in the image analysis sequence is configured such that the processing operation associated with the processing step processes a specified input image to generate an output image when the processing step is performed. A display signal is generated for display of the output image at a display device.

摘要翻译： 提供了使用多个处理操作来处理所选图像的计算机实现的方法。 构建具有多个处理步骤的图像分析序列。 响应于接收到多个处理操作选择而构建图像分析序列。 图像分析序列中的各个处理步骤与在相应的处理操作选择中指示的处理操作相关联。 响应于接收到与处理步骤的选择性布置相关的布置信息来布置处理步骤。 图像分析序列中的至少一个处理步骤被配置为使得与处理步骤相关联的处理操作处理指定的输入图像以在执行处理步骤时生成输出图像。 生成用于在显示装置处显示输出图像的显示信号。

公开(公告)号：US20130058524A1

公开(公告)日：2013-03-07

申请号：US13225021

申请日：2011-09-02

申请人： Avrum Isaac Cohen ,  Dihui Hong

发明人： Avrum Isaac Cohen ,  Dihui Hong

IPC分类号： G06K9/00

CPC分类号： G06K9/00134 ,  G06K9/6253 ,  G06T7/0012 ,  G06T7/11 ,  G06T7/136 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/20081 ,  G06T2207/20152 ,  G06T2207/30024

摘要： A computer-implemented method of processing a selected image using multiple processing operations is provided. An image analysis sequence having multiple processing steps is constructed. The image analysis sequence is constructed in response to receipt of multiple processing operation selections. Individual processing steps in the image analysis sequence are associated with a processing operation that is indicated in a corresponding processing operation selection. The processing steps are arranged in response to receipt of arrangement information that relates to a selective arrangement of the processing steps. At least one of the processing steps in the image analysis sequence is configured such that the processing operation associated with the processing step processes a specified input image to generate an output image when the processing step is performed. A display signal is generated for display of the output image at a display device.

摘要翻译： 提供了使用多个处理操作来处理所选图像的计算机实现的方法。 构建具有多个处理步骤的图像分析序列。 响应于接收到多个处理操作选择而构建图像分析序列。 图像分析序列中的各个处理步骤与在相应的处理操作选择中指示的处理操作相关联。 响应于接收到与处理步骤的选择性布置相关的布置信息来布置处理步骤。 图像分析序列中的至少一个处理步骤被配置为使得与处理步骤相关联的处理操作在执行处理步骤时处理指定的输入图像以生成输出图像。 生成用于在显示装置处显示输出图像的显示信号。