公开(公告)号：US06360138B1

公开(公告)日：2002-03-19

申请号：US09543530

申请日：2000-04-06

申请人： Richard G. Coppola ,  David Biedermann ,  Charles Fort

发明人： Richard G. Coppola ,  David Biedermann ,  Charles Fort

IPC分类号： G06F1700

CPC分类号： G07F7/1008 ,  G06Q20/341 ,  G07F7/084 ,  G07F13/025 ,  G07G1/14 ,  H04L29/06 ,  H04L69/16 ,  H04L69/169

摘要： A fuel station site architecture includes at least one point-of-sale (POS) controller, at least one new generation fuel dispenser having advanced features, and a site forecourt controller coupled between the POS controller and the fuel dispenser. The site forecourt controller includes a device for interfacing the POS controller with the fuel dispenser by providing a protocol and electrical signal interface between a first protocol and electrical signal requirement of the POS controller and a second protocol and electrical signal requirement of the fuel dispenser, wherein the second protocol and electrical signal requirement include requirements for features which may not be supported by a prescribed POS controller.

摘要翻译： 燃料站站点架构包括至少一个销售点（POS）控制器，具有高级特征的至少一个新一代燃料分配器，以及耦合在POS控制器和燃料分配器之间的站点前场控制器。 场地前场控制器包括：通过在POS控制器的第一协议和电信号要求之间提供协议和电信号接口以及燃料分配器的第二协议和电信号要求来将POS控制器与燃料分配器接口的设备，其中 第二协议和电信号要求包括对规定的POS控制器可能不支持的特征的要求。

公开(公告)号：US20090325919A1

公开(公告)日：2009-12-31

申请号：US12443304

申请日：2007-09-25

申请人： Jan Sarek ,  Marian Hajduch ,  Michal Svoboda ,  Katerina Novakova ,  Pavia Spacilova ,  Tomas Kubelka ,  David Biedermann

发明人： Jan Sarek ,  Marian Hajduch ,  Michal Svoboda ,  Katerina Novakova ,  Pavia Spacilova ,  Tomas Kubelka ,  David Biedermann

IPC分类号： A61K31/58 ,  C07J71/00 ,  C07D307/77 ,  A61K31/343 ,  C07C69/76 ,  A61K31/215 ,  C07J1/00 ,  A61K31/56

CPC分类号： C07J71/0047 ,  A61K31/56 ,  A61K47/6951 ,  B82Y5/00 ,  C07J63/008

摘要： The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a substituent selected from the group comprising substituents of general formula Xa bound to the hydroxy group of the terpenoid, wherein Xa is —OC—R—COOH, substituents of general formula Xa bound to the amino group of the terpenoid, wherein Xa is —OC—R—COOH, quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is —(CH2)nN+R3Y—, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je —(CH2)nR+Y—, substituents of general formula Xd bound to the carboxy group of the terpenoid, wherein Xd represents —R—COOH, glycosylic substituents Xe bound by alpha or beta glycosidic bond to the hydroxy group or to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lactosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetracyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation.

公开(公告)号：US08653056B2

公开(公告)日：2014-02-18

申请号：US12443304

申请日：2007-09-25

申请人： Jan Sarek ,  Marian Hajduch ,  Michal Svoboda ,  Katerina Novakova ,  Pavla Spacilova ,  Tomas Kubelka ,  David Biedermann

发明人： Jan Sarek ,  Marian Hajduch ,  Michal Svoboda ,  Katerina Novakova ,  Pavla Spacilova ,  Tomas Kubelka ,  David Biedermann

IPC分类号： A61K31/56 ,  C07J1/00

CPC分类号： C07J71/0047 ,  A61K31/56 ,  A61K47/6951 ,  B82Y5/00 ,  C07J63/008

摘要： The invention relates to a method of preparation of a soluble formulation of water-insoluble pentacyclic and tetracyclic terpenoids, wherein the water-insoluble terpenoid having a free carboxylic, hydroxy or amino functional group is derivatized on this functional group with a substituent selected from the group comprising substituents of general formula Xa bound to the hydroxy group of the terpenoid, wherein Xa is —OC—R—COOH, substituents of general formula Xa bound to the amino group of the terpenoid, wherein Xa is —OC—R—COOH, quarternary ammonium substituents of general formula Xb bound to the carboxy group of the terpenoid, wherein Xb is —(CH2)nN+R3Y—, quarternary ammonium substituents of general formula Xc bound to the carboxy group of the terpenoid, wherein Xc je —(CH2)nR+Y—, substituents of general formula Xd bound to the carboxy group of the terpenoid, wherein Xd represents —R—COOH, glycosylic substituents Xe bound by alpha or beta glycosidic bond to the hydroxy group or to the carboxy group of the terpenoid, wherein Xe is selected from the group comprising glucosyl, galactosyl, arabinosyl, rhamnosyl, lactosyl, cellobiosyl, maltosyl and the 2-deoxyanalogues thereof, and subsequently, the prepared derivative is dissolved in the solution containing water, a cyclodextrin and optionally pharmaceutically acceptable auxiliary substances, forming an inclusion derivative with the cyclodextrin. Object of the invention is further a soluble formulation of a pentacyclic or tetracyclic triterpenoid, containing an inclusion complex of the derivatized pentacyclic or tetracyclic terpenoid with a cyclodextrin, and optionally water and pharmaceutically acceptable auxiliary substances and further a pharmaceutical composition containing the soluble formulation.