公开(公告)号：US5948930A

公开(公告)日：1999-09-07

申请号：US927850

申请日：1997-09-11

Applicant: David M. Mayes ,  Daniel M. Wasleski ,  Gerd Grah ,  Hermann Seifert

Inventor： David M. Mayes ,  Daniel M. Wasleski ,  Gerd Grah ,  Hermann Seifert

IPC: C07F9/20 ,  C07F9/16

CPC classification number: C07F9/20

Abstract: The invention relates to process for the preparation of an O-alkyl, O-alkyl phosphorochloridothioate by 1) reacting A) a thiophosphoryl halide with B) an alcohol, in the presence of C) a tertiary amine acid acceptor and D) a solvent, and 2) reacting the resultant product with a second alcohol, different from the alcohol used in step 1). In the preferred embodiment, the intermediate product is not isolated before reaction with the second alcohol.

Abstract translation: 本发明涉及通过以下步骤制备O-烷基，O-烷基氯代硫代磷酸酯的方法：1）在C）叔胺酸受体和D）溶剂的存在下，使A）硫代磷酰卤与B）醇反应， 和2）使所得产物与不同于步骤1）中使用的醇的第二醇反应。 在优选的实施方案中，中间产物在与第二醇反应之前不分离。

公开(公告)号：US5895818A

公开(公告)日：1999-04-20

申请号：US989597

申请日：1997-12-12

Applicant: Vidyanatha A. Prasad ,  Peter E. Newallis ,  Daniel M. Wasleski ,  Jacqueline M. Applegate ,  Klaus Jelich

Inventor： Vidyanatha A. Prasad ,  Peter E. Newallis ,  Daniel M. Wasleski ,  Jacqueline M. Applegate ,  Klaus Jelich

IPC: C07D285/13 ,  A01N43/824 ,  C07D285/12

CPC classification number: C07D285/12

Abstract: The present invention relates to a process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-�(5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy!acetamide in an aprotic, aromatic solvent. The process includes the steps of: (a) reacting 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4-thiadiazole with N-(4-fluorophenyl)-2-hydroxy-N-(1-methylethyl)acetamide in the presence of an aprotic, aromatic solvent to form an aqueous phase and an organic phase; (b) acidifying the phases, (c) separating the phases; and (d) recovering the N-(4-fluorophenyl)-N-(1-methylethyl)-2-�(5-trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy!acetamide from the organic phase.

Abstract translation: 本发明涉及制备N-（4-氟苯基）-N-（1-甲基乙基）-2 - [（5-三氟甲基）-1,3,4-噻二唑-2-基）氧基]乙酰胺的方法 非质子，芳香族溶剂。 该方法包括以下步骤：（a）使2-（甲基磺酰基）-5-（三氟甲基）-1,3,4-噻二唑与N-（4-氟苯基）-2-羟基-N-（1-甲基乙基） 乙酰胺在非质子芳香族溶剂的存在下形成水相和有机相; （b）使相酸化，（c）分离相; 和（d）从有机相中回收N-（4-氟苯基）-N-（1-甲基乙基）-2 - [（5-三氟甲基）-1,3,4-噻二唑-2-基）氧基]乙酰胺 。

公开(公告)号：US5118842A

公开(公告)日：1992-06-02

申请号：US615829

申请日：1990-11-16

Applicant: Peter E. Newallis ,  Jeffrey D. Macke ,  Karl G. Steinbeck ,  Daniel M. Wasleski

Inventor： Peter E. Newallis ,  Jeffrey D. Macke ,  Karl G. Steinbeck ,  Daniel M. Wasleski

IPC: C07C381/12

CPC classification number: C07C381/12

Abstract: Trimethylsulfonium halides are made by reacting dimethyl sulfide and a methyl halide in the presence of a solvent mixture which includes water and a water-immiscible organic solvent. The organic water-immiscible solvent is generally present in an amount which is at least 40% but no more than 95% of the total solvent mixture. The reaction is preferably conducted under pressure.

Abstract translation: 三甲基锍卤化物通过二甲基硫醚和甲基卤化物在包括水和与水不混溶的有机溶剂的溶剂混合物存在下反应制备。 有机水不混溶溶剂的存在量通常为总溶剂混合物的至少40％但不超过95％。 反应优选在压力下进行。

公开(公告)号：US5792872A

公开(公告)日：1998-08-11

申请号：US989564

申请日：1997-12-12

Applicant: Vidyanatha A. Prasad ,  Jacqueline M. Applegate ,  Daniel M. Wasleski ,  Klaus Jelich

Inventor： Vidyanatha A. Prasad ,  Jacqueline M. Applegate ,  Daniel M. Wasleski ,  Klaus Jelich

IPC: A01N43/824 ,  C07D285/12 ,  C07D285/13

CPC classification number: C07D285/13

Abstract: The present invention relates to a process for making N-(4-fluorophenyl)-N-(1-methylethyl)-2-�(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy!acetamide, which process includes the steps of reacting 2-(methylsulfonyl)-5-(trifluoromethyl)-1,3,4,-thiadiazole with N-(4-fluorophenyl)-2-hydroxy-N(1-methylethyl)acetamide in an aprotic, aromatic solvent with aqueous alkali to form an aqueous phase and an organic phase, separating the aqueous and organic phases and recovering the N-(4-fluorophenyl)-N-(1-methylethyl)-2-�(5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)oxy!acetamide from the organic phase. A preferred solvent and aqueous alkali are toluene and aqueous sodium hydroxide, respectively.

Abstract translation: 本发明涉及制备N-（4-氟苯基）-N-（1-甲基乙基）-2 - [（5-（三氟甲基）-1,3,4-噻二唑-2-基）氧基]乙酰胺 ，该方法包括使2-（甲基磺酰基）-5-（三氟甲基）-1,3,4， - 噻二唑与N-（4-氟苯基）-2-羟基-N（1-甲基乙基）乙酰胺反应的步骤 非质子芳族溶剂与水溶液形成水相和有机相，分离水相和有机相，并回收N-（4-氟苯基）-N-（1-甲基乙基）-2 - [（5-（三氟甲基） ）-1,3,4-噻二唑-2-基）氧基]乙酰胺。 优选的溶剂和碱水溶液分别是甲苯和氢氧化钠水溶液。

公开(公告)号：US5877339A

公开(公告)日：1999-03-02

申请号：US743764

申请日：1996-11-07

Applicant: Daniel M. Wasleski ,  Peter E. Newallis ,  Dennis E. Jackman ,  David T. Erdman ,  Jeffrey D. Macke ,  Vidyanatha A. Prasad ,  Vijay C. Desai

Inventor： Daniel M. Wasleski ,  Peter E. Newallis ,  Dennis E. Jackman ,  David T. Erdman ,  Jeffrey D. Macke ,  Vidyanatha A. Prasad ,  Vijay C. Desai

IPC: C07C337/02

CPC classification number: C07C337/02

Abstract: Disclosed herein is an aqueous process for preparing high yields of methyl dithiocarbazinate by reacting carbon disulfide and hydrazine in an effective ratio, in an aqueous medium to form hydrazinium dithiocarbazinate salt followed by methylating the hydrazinium dithiocarbazinate with methyl bromide.

Abstract translation: 本文公开了一种水性方法，其通过使二硫化碳和肼以有效的比例在水性介质中反应制备高产率的二硫代肼基甲酸甲酯以形成二硫代肼基肼基肼盐，然后用甲基溴甲基化二硫代肼基肼。

公开(公告)号：US3666814A

公开(公告)日：1972-05-30

申请号：US3666814D

申请日：1970-03-03

Applicant: DELTA W GIER ,  DANIEL M WASLESKI

Inventor： GIER DELTA W ,  WASLESKI DANIEL M

IPC: C07C49/80

CPC classification number: C07C205/45

Abstract: Compounds of the formula WHERE R is alkyl, cycloalkyl, dihalo triazinyl, quinoxalinyl, alkyl quinoxalinyl, acetonyl, arylketoalkyl, epoxyalkyl, aminoarylketoalkyl, haloarylketoalkyl, X is halogen, Y is nitro, n is an integer of 1 to 3 and m is an integer of 1 to 2 have been found useful as nematocides, herbicides, fungicides and desiccants.

Abstract translation: 式的化合物，其中R是烷基，环烷基，二卤代三嗪基，喹喔啉基，烷基喹喔啉基，丙酮基，芳基酮基烷基，环氧烷基，氨基芳基酮烷基，卤代芳基酮烷基，X是卤素，Y是硝基，n是1至3的整数，m是整数 已发现1至2种可用作杀线虫剂，除草剂，杀真菌剂和干燥剂。

公开(公告)号：US6025514A

公开(公告)日：2000-02-15

申请号：US157483

申请日：1998-09-21

Applicant: Dennis E. Jackman ,  David T. Erdman ,  Peter E. Newallis ,  Daniel M. Wasleski ,  Vijay C. Desai ,  Jeffrey D. Macke ,  Vidyanatha A. Prasad

Inventor： Dennis E. Jackman ,  David T. Erdman ,  Peter E. Newallis ,  Daniel M. Wasleski ,  Vijay C. Desai ,  Jeffrey D. Macke ,  Vidyanatha A. Prasad

IPC: C07C337/02 ,  C07C333/28

CPC classification number: C07C337/02

Abstract: Disclosed herein is a process for preparing high yields of methyl dithiocarbazinate by reacting carbon disulfide, hydrazine and a base in an aqueous medium, in an effective ratio to form a dithiocarbazinate salt followed by methylating the dithiocarbazinate salt with methyl bromide.

Abstract translation: 本文公开了通过使二硫代肼，肼和碱在水性介质中以有效的比例以有效的比例反应制备高产率的二硫代肼基甲酸甲酯的方法，以形成二硫代肼基甲酸盐，然后用甲基溴甲基化二硫代肼基甲酸盐。

公开(公告)号：US5502190A

公开(公告)日：1996-03-26

申请号：US151322

申请日：1993-11-12

Applicant: Daniel M. Wasleski ,  David T. Erdman ,  Peter E. Newallis

Inventor： Daniel M. Wasleski ,  David T. Erdman ,  Peter E. Newallis

IPC: C07F9/6512

CPC classification number: C07F9/65125

Abstract: O,O-dialkyl pyrimidylphosphates are made by reacting an O,O-dialkyl phosphorohalothioate with a 5-hydroxypyrimidine in the presence of an imidazole phase transfer catalyst, an aromatic solvent and an alkali metal hydroxide at a pH of from about 8 to about 12 and a temperature of up to about 70.degree. C. The products of this process are obtained in high yield. These compounds are useful as pesticides and insecticides.

Abstract translation: O，O-二烷基嘧啶基磷酸酯通过在咪唑相转移催化剂，芳族溶剂和碱金属氢氧化物存在下，在约8至约12的pH下，使O，O-二烷基硫代磷酸酯与5-羟基嘧啶反应制备 并且温度高达约70℃。该方法的产物以高产率获得。 这些化合物可用作农药和杀虫剂。