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1.发明授权公开(公告)号：US08293776B2
公开(公告)日：2012-10-23
申请号：US12536390
申请日：2009-08-05
IPC分类号： A61K31/41
CPC分类号： G01N33/566 , A61K31/56 , G01N2500/02
摘要： The present invention provides compositions and methods for treating inflammatory conditions (e.g., of the bowel). In particular, the present invention provides methods of treating (e.g., therapeutically and/or prophylactically treating) inflammatory conditions (e.g., of the bowel), compositions useful for such methods (e.g., antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1a (AT1a)), and methods of identifying, characterizing and/or optimizing such compositions. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.
摘要翻译： 本发明提供用于治疗炎性病症（例如肠）的组合物和方法。 特别地，本发明提供了治疗（例如，治疗和/或预防性治疗）炎性病症（例如肠）的方法，用于这些方法的组合物（例如拮抗剂和/或血管紧张素II（AngII）受体的抑制剂） 类型1a（AT1a））以及鉴定，表征和/或优化这些组合物的方法。 本发明的组合物和方法尤其用于临床（例如治疗和预防性药物）和研究应用。
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公开(公告)号：US08268009B2
公开(公告)日：2012-09-18
申请号：US12420995
申请日：2009-04-09
申请人： Daniel H. Teitelbaum , Jonathan E. Luntz , Ariel U. Spencer , Diann E. Brei , Brent A. Utter , Joseph T. Belter , Jennifer L. Vermeesch , Alexander D. Farr , Makram P. Debbas
发明人： Daniel H. Teitelbaum , Jonathan E. Luntz , Ariel U. Spencer , Diann E. Brei , Brent A. Utter , Joseph T. Belter , Jennifer L. Vermeesch , Alexander D. Farr , Makram P. Debbas
CPC分类号： A61F2/04
摘要： A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.
摘要翻译： 可延伸到体内用于治疗短肠综合症的肠扩张装置。 肠扩张装置包括壳体和联接到壳体的可移位构件。 肠延伸装置构造成施加足以促进肠生长而不引起肠损伤的张力。 在一些实施例中，肠扩张装置可以与身体完全容纳。
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公开(公告)号：US07722560B2
公开(公告)日：2010-05-25
申请号：US11673193
申请日：2007-02-09
CPC分类号： A61F2/04
摘要： A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.
摘要翻译： 可延伸到体内用于治疗短肠综合症的肠扩张装置。 肠扩张装置包括壳体和联接到壳体的可移位构件。 肠延伸装置构造成施加足以促进肠生长而不引起肠损伤的张力。 在一些实施例中，肠扩张装置可以与身体完全容纳。
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公开(公告)号：US20090240339A1
公开(公告)日：2009-09-24
申请号：US12420995
申请日：2009-04-09
申请人： DANIEL H. TEITELBAUM , Jonathan E. Luntz , Ariel U. Spencer , Diann E. Brei , Brent A. Utter , Joseph T. Belter , Jehnifer L. Vermeesch , Alexander D. Farr , Makram P. Debbas
发明人： DANIEL H. TEITELBAUM , Jonathan E. Luntz , Ariel U. Spencer , Diann E. Brei , Brent A. Utter , Joseph T. Belter , Jehnifer L. Vermeesch , Alexander D. Farr , Makram P. Debbas
IPC分类号： A61F2/04
CPC分类号： A61F2/04
摘要： A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.
摘要翻译： 可延伸到体内用于治疗短肠综合症的肠扩张装置。 肠扩张装置包括壳体和联接到壳体的可移位构件。 肠延伸装置构造成施加足以促进肠生长而不引起肠损伤的张力。 在一些实施例中，肠扩张装置可以与身体完全容纳。
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5.发明申请公开(公告)号：US20100035852A1
公开(公告)日：2010-02-11
申请号：US12536390
申请日：2009-08-05
CPC分类号： G01N33/566 , A61K31/56 , G01N2500/02
摘要： The present invention provides compositions and methods for treating inflammatory conditions (e.g., of the bowel). In particular, the present invention provides methods of treating (e.g., therapeutically and/or prophylactically treating) inflammatory conditions (e.g., of the bowel), compositions useful for such methods (e.g., antagonists and/or inhibitors of angiotensin II (AngII) receptor Type 1a (AT1a)), and methods of identifying, characterizing and/or optimizing such compositions. Compositions and methods of the present invention find use in, among other things, clinical (e.g. therapeutic and preventative medicine) and research applications.
摘要翻译： 本发明提供用于治疗炎性病症（例如肠）的组合物和方法。 特别地，本发明提供了治疗（例如，治疗和/或预防性治疗）炎性病症（例如肠）的方法，用于这些方法的组合物（例如拮抗剂和/或血管紧张素II（AngII）受体的抑制剂） 类型1a（AT1a））以及鉴定，表征和/或优化这些组合物的方法。 本发明的组合物和方法尤其用于临床（例如治疗和预防性药物）和研究应用。
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公开(公告)号：US08080579B2
公开(公告)日：2011-12-20
申请号：US11542576
申请日：2006-10-03
IPC分类号： A61K31/40
CPC分类号： A61K31/00 , A61K9/0031 , A61K31/401 , A61K31/403 , A61K31/573 , A61K45/06 , A61K2300/00
摘要： The present invention provides compositions and methods for treating inflammatory bowel disease. In particular, the present invention provides methods of therapeutically treating symptoms of inflammatory bowel disease using compositions comprising an angiotensin converting enzyme (ACE) inhibitor and polyethylene glycol.
摘要翻译： 本发明提供治疗炎症性肠病的组合物和方法。 特别地，本发明提供使用包含血管紧张素转换酶（ACE）抑制剂和聚乙二醇的组合物治疗性治疗炎性肠病的症状的方法。
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公开(公告)号：US20080195224A1
公开(公告)日：2008-08-14
申请号：US11673193
申请日：2007-02-09
IPC分类号： A61F2/04
CPC分类号： A61F2/04
摘要： A bowel extension device implantable into a body for treatment of short bowel syndrome. The bowel extension device comprises a housing and a displaceable member coupled to the housing. The bowel extension device is configured to apply a tensile force sufficient to promote bowel growth without causing damage to the bowel. In some embodiments, the bowel extension device can be completely contained with the body.
摘要翻译： 可延伸到体内用于治疗短肠综合症的肠扩张装置。 肠扩张装置包括壳体和联接到壳体的可移位构件。 肠延伸装置构造成施加足以促进肠生长而不引起肠损伤的张力。 在一些实施例中，肠扩张装置可以与身体完全容纳。
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