公开(公告)号：US08486448B2

公开(公告)日：2013-07-16

申请号：US12336495

申请日：2008-12-16

申请人： Miloud Rahmouni ,  Angela Ferrada ,  Fouzia Soulhi ,  Sonia Gervais ,  Vinayak Sant ,  Damon Smith ,  Frederic Duffayet ,  Shams Rustom ,  Ali El-Jammal ,  Jean-Michel Ndong ,  Bobby-Ernst Boursiquot ,  Ali Bichara

发明人： Miloud Rahmouni ,  Angela Ferrada ,  Fouzia Soulhi ,  Sonia Gervais ,  Vinayak Sant ,  Damon Smith ,  Frederic Duffayet ,  Shams Rustom ,  Ali El-Jammal ,  Jean-Michel Ndong ,  Bobby-Ernst Boursiquot ,  Ali Bichara

IPC分类号： A61K9/20

CPC分类号： A61K9/2081 ,  A61K9/14 ,  A61K9/20 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/2027 ,  A61K9/2031 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/209 ,  A61K9/28 ,  A61K9/2813 ,  A61K9/282 ,  A61K9/284 ,  A61K9/2846 ,  A61K9/286 ,  A61K9/2866 ,  A61K9/50 ,  A61K31/00 ,  A61K31/135 ,  A61K31/137 ,  A61K31/167 ,  A61K31/485

摘要： Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the core, and a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed within the core, the coat, or both the core and the coat. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present in the core swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the formulation. Also disclosed is a method of using the misuse preventative, controlled release formulation to deliver a pharmaceutically active agent to a mammal, for example, a human, in need thereof.

摘要翻译： 公开了一种滥用预防性控制释放制剂，其包含包含超吸收材料（例如，聚卡波非）的核心，围绕该核心的控释包衣以及具有药物活性剂（例如，阿片样物质止痛剂）的多个控制释放微粒 ）设置在芯部，外壳中，或芯部和外壳两者之间。 当被故意地或意外地粉碎并暴露于含水介质时，存在于芯中的超吸收材料溶胀以包封微粒，其保持基本上完整，从而延缓药物活性剂从制剂中的释放。 还公开了使用滥用预防性控制释放制剂将药学活性剂递送至有需要的哺乳动物例如人的方法。

公开(公告)号：US20110027370A1

公开(公告)日：2011-02-03

申请号：US12905567

申请日：2010-10-15

申请人： Sonia Gervais ,  Damon Smith ,  Pauline Contamin ,  Rachid Ouzerourou ,  My Linh Ma

发明人： Sonia Gervais ,  Damon Smith ,  Pauline Contamin ,  Rachid Ouzerourou ,  My Linh Ma

IPC分类号： A61K9/00

CPC分类号： A61K9/2072 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/28 ,  A61K9/2866 ,  A61K31/135 ,  A61K31/16 ,  A61K31/167 ,  A61K31/4402 ,  A61K31/496

摘要： The invention relates to a sustained release formulation for delivering one or more pharmaceutically active agents. The formulation comprises cross-linked high amylose starch and at least one pharmaceutically active agent, and optionally can be subdivided into smaller dosage forms where the smaller dosage forms have substantially the same sustained release properties as the formulation from which they were derived. The formulations can provide sustained release for up to at least 24 hours, and because of their divisability permits a recipient of the active agent or the person administering the active agent to titrate the dosage of the agent.

摘要翻译： 本发明涉及用于递送一种或多种药物活性剂的持续释放制剂。 该制剂包含交联的高直链淀粉和至少一种药物活性剂，并且任选地可以分成更小的剂型，其中较小的剂型具有与其衍生的制剂基本相同的持续释放性质。 制剂可以提供至多24小时的持续释放，并且由于它们的分裂性使得活性剂的接受者或施用活性剂的人剂滴定该剂的剂量。

公开(公告)号：US20110021535A1

公开(公告)日：2011-01-27

申请号：US12892454

申请日：2010-09-28

申请人： Sonia Gervais ,  Damon Smith ,  Miloud Rahmouni ,  Pauline Contamin ,  Rachid Ouzerourou ,  My Linh Ma ,  Angela Ferrada ,  Fouzia Soulhi

发明人： Sonia Gervais ,  Damon Smith ,  Miloud Rahmouni ,  Pauline Contamin ,  Rachid Ouzerourou ,  My Linh Ma ,  Angela Ferrada ,  Fouzia Soulhi

IPC分类号： A61K31/496 ,  A61P25/20 ,  A61P25/24

CPC分类号： A61K9/2072 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/28 ,  A61K9/2866 ,  A61K31/135 ,  A61K31/16 ,  A61K31/167 ,  A61K31/4402 ,  A61K31/496

摘要： The invention relates to a once a day formulation of trazodone or a trazodone derivative. The formulation contains trazodone or a trazodone derivative and a controlled release excipient so that, once administered orally, the trazodone or the trazodone derivative is maintained at a therapeutic plasma concentration from at least 1 hour to at least 24 hours after initial administration. After administration, the initial therapeutic action takes effect within the first hour and lasts at least about 24 hours. This therapeutic effect remains relatively and substantially stable for the remaining period of 24 hours. The formulations can be used for treating depression and/or sleeping disorders.

摘要翻译： 本发明涉及曲唑酮或曲唑酮衍生物每天一次的制剂。 制剂含有曲唑酮或曲唑酮衍生物和控制释放赋形剂，使得一旦口服给药，曲唑酮或曲唑酮衍生物在治疗血浆浓度后维持在初次给药后至少1小时至至少24小时。 给药后，初始治疗作用在第一小时内生效，持续至少约24小时。 这种治疗效果在24小时的剩余时间内保持相对且基本稳定。 制剂可用于治疗抑郁症和/或睡眠障碍。

公开(公告)号：US20110015205A1

公开(公告)日：2011-01-20

申请号：US12892466

申请日：2010-09-28

申请人： Sonia Gervais ,  Damon Smith ,  Miloud Rahmouni ,  Pauline Contamin ,  Rachid Ouzerourou ,  My Linh Ma ,  Angela Ferrada ,  Fouzia Soulhi

发明人： Sonia Gervais ,  Damon Smith ,  Miloud Rahmouni ,  Pauline Contamin ,  Rachid Ouzerourou ,  My Linh Ma ,  Angela Ferrada ,  Fouzia Soulhi

IPC分类号： A61K31/496 ,  A61P25/24

CPC分类号： A61K9/2072 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/28 ,  A61K9/2866 ,  A61K31/135 ,  A61K31/16 ,  A61K31/167 ,  A61K31/4402 ,  A61K31/496

摘要： The invention relates to a once a day formulation of trazodone or a trazodone derivative. The formulation contains trazodone or a trazodone derivative and a controlled release excipient so that, once administered orally, the trazodone or the trazodone derivative is maintained at a therapeutic plasma concentration from at least 1 hour to at least 24 hours after initial administration. After administration, the initial therapeutic action takes effect within the first hour and lasts at least about 24 hours. This therapeutic effect remains relatively and substantially stable for the remaining period of 24 hours. The formulations can be used for treating depression and/or sleeping disorders.

公开(公告)号：US20100313530A1

公开(公告)日：2010-12-16

申请号：US12796104

申请日：2010-06-08

申请人： Damon SMITH ,  David Dronsfield

发明人： Damon SMITH ,  David Dronsfield

IPC分类号： B65B43/26

CPC分类号： B43M3/045

摘要： An apparatus for inserting a document into an envelope, the apparatus comprising: means for holding an envelope at an insert station; pivotally mounted fingers for opening the envelope; and means for moving the document to be inserted along a platform over the fingers and into the envelope; wherein the platform is pivoted at an upstream end and upwardly spring biased so that the platform is depressed against the spring bias, by an amount dependent on the weight of the insert document moving over, so that a light insert document follows a path which subtends a steeper angle to the horizontal compared to a heavy insert document.

摘要翻译： 一种用于将文件插入信封中的装置，所述装置包括：用于在插入台处保持信封的装置; 用于打开信封的枢转安装的手指; 以及用于将沿着平台的文档移动到手指上并进入信封的装置; 其中所述平台在上游端枢转并且向上弹簧偏置，使得所述平台抵抗所述弹簧偏压被减小一定量，所述量取决于所述插入文件移动的重量，使得光插入文件遵循与 与重型插入文件相比，水平面的角度更为陡峭。

公开(公告)号：US20090047345A9

公开(公告)日：2009-02-19

申请号：US11112008

申请日：2005-04-22

申请人： Vincent Lenaerts ,  Laure Ouadji-Njiki ,  Johnatan Bacon ,  Rachid Ouzerourou ,  Sonia Gervais ,  Miloud Rahmouni ,  Damon Smith

发明人： Vincent Lenaerts ,  Laure Ouadji-Njiki ,  Johnatan Bacon ,  Rachid Ouzerourou ,  Sonia Gervais ,  Miloud Rahmouni ,  Damon Smith

IPC分类号： A61K9/22

CPC分类号： A61K9/209 ,  A61K9/2059 ,  A61K9/2077 ,  A61K9/2095 ,  A61K9/2853 ,  A61K9/286

摘要： A sustained-release tramadol formulation oral administration is provided which, upon initial administration of one dose, provides an analgesic effect within 2 hours, which analgesic effect continues for at least 24 hours after administration

摘要翻译： 提供持续释放曲马多口服给药，其在初次给药一剂后，在2小时内提供镇痛作用，其镇痛作用在给药后持续至少24小时

公开(公告)号：US20060198891A1

公开(公告)日：2006-09-07

申请号：US11286301

申请日：2005-11-25

申请人： Francois Ravenelle ,  Sandra Gori ,  David Lessard ,  Laibin Luo ,  Dorothee Garrec ,  Damon Smith

发明人： Francois Ravenelle ,  Sandra Gori ,  David Lessard ,  Laibin Luo ,  Dorothee Garrec ,  Damon Smith

IPC分类号： A61K9/14

摘要： The instant invention relates to a solid product comprising a liquid biologically active agent which is intimately associated to a stabilizing agent; particularly a solid product that can be reconstituted to a clear, stable, stabilized nanodispersion or loaded micelles comprising a polymer as a stabilizing agent and a liquid, preferably water immiscible, biologically active agent. The instant invention is further directed toward a process for the production of the above solid product; particularly to micelles or nanodispersions produced by hydration of a cake or powder of the solid product, produced via an effective treatment of a stabilized solution comprising for example a polymer as a stabilizing agent, such as an amphiphilic block copolymer or a small molecular weight surfactant, loaded with a liquid biologically active agent, such as propofol, an optional additive, and a suitable solvent.

摘要翻译： 本发明涉及包含与稳定剂紧密结合的液体生物活性剂的固体产品; 特别是可以重构为透明，稳定，稳定的纳米分散体或负载胶束的固体产物，其包含作为稳定剂的聚合物和液体，优选与水不混溶的生物活性剂。 本发明进一步涉及生产上述固体产品的方法; 特别是通过有效处理包含例如作为稳定剂的聚合物如两亲性嵌段共聚物或小分子量表面活性剂的稳定溶液产生的固体产物的饼或粉末的水合产生的胶束或纳米分散体， 装载有液体生物活性剂，例如丙泊酚，任选的添加剂和合适的溶剂。

公开(公告)号：US08590694B2

公开(公告)日：2013-11-26

申请号：US12795927

申请日：2010-06-08

申请人： Damon Smith

发明人： Damon Smith

IPC分类号： B65G17/12 ,  B65G17/30

CPC分类号： B65H31/3081 ,  B43M3/04 ,  B65H2301/42266 ,  B65H2403/724 ,  B65H2404/311 ,  B65H2404/33 ,  B65H2515/32 ,  B65H2220/02

摘要： Apparatus for transporting documents in a paper handling system, comprising: a drive train; a document transport element connected to the drive train for moving documents; and means adapted to apply a relatively high voltage element to generate a high torque when the transport element is not loaded and to reduce the voltage and thus the torque a predetermined time after the transport element engages a document to be moved.

摘要翻译： 用于在纸张处理系统中运送文件的装置，包括：传动系; 文档传送元件，连接到用于移动文件的传动系; 以及适于在传送元件未被加载时施加相对较高的电压元件以产生高扭矩的装置，并且在传送元件接合要移动的文件之后的预定时间内减小电压并因此降低转矩。

公开(公告)号：US08453418B2

公开(公告)日：2013-06-04

申请号：US12796104

申请日：2010-06-08

申请人： Damon Smith ,  David Dronsfield

发明人： Damon Smith ,  David Dronsfield

IPC分类号： B43M3/04

CPC分类号： B43M3/045

摘要： An apparatus for inserting a document into an envelope. The apparatus includes a mechanism for holding an envelope at an insert station; pivotally mounted fingers for opening the envelope; and a platform for guiding the document over the fingers and into the envelope. The platform is pivoted at an upstream end and upwardly spring biased so that the platform is depressed against the spring bias, by an amount dependent on the weight of the insert document moving over, so that a light insert document follows a path which subtends a steeper angle to the horizontal compared to a heavy insert document.

摘要翻译： 一种将文件插入信封中的装置。 该装置包括用于在插入台处保持封套的机构; 用于打开信封的枢转安装的手指; 以及用于将文件引导到手指上并进入信封的平台。 平台在上游端枢转并且向上弹簧偏置，使得平台抵抗弹簧偏压被减小一定量，这取决于移动的插入物文件的重量，使得光插入物文档遵循一个路径，其对准较陡峭的 与重型插入文档相比，与水平方向的角度相比。

公开(公告)号：US20110033537A1

公开(公告)日：2011-02-10

申请号：US12905577

申请日：2010-10-15

申请人： Sonia Gervais ,  Damon Smith ,  Pauline Contamin ,  Rachid Ouzerourou ,  My Linh Ma

发明人： Sonia Gervais ,  Damon Smith ,  Pauline Contamin ,  Rachid Ouzerourou ,  My Linh Ma

IPC分类号： A61K9/22 ,  A61K9/10 ,  A61K31/496 ,  A61P29/00 ,  A61P25/24

CPC分类号： A61K9/2072 ,  A61K9/205 ,  A61K9/2054 ,  A61K9/2059 ,  A61K9/28 ,  A61K9/2866 ,  A61K31/135 ,  A61K31/16 ,  A61K31/167 ,  A61K31/4402 ,  A61K31/496

摘要： The invention relates to a sustained release formulation for delivering one or more pharmaceutically active agents. The formulation comprises cross-linked high amylose starch and at least one pharmaceutically active agent, and optionally can be subdivided into smaller dosage forms where the smaller dosage forms have substantially the same sustained release properties as the formulation from which they were derived. The formulations can provide sustained release for up to at least 24 hours, and because of their divisability permits a recipient of the active agent or the person administering the active agent to titrate the dosage of the agent.