Thioamides of beta-lactam antibiotics
    1.
    发明授权
    Thioamides of beta-lactam antibiotics 失效
    β-内酰胺抗生素的硫胺

    公开(公告)号:US4035354A

    公开(公告)日:1977-07-12

    申请号:US571426

    申请日:1975-04-24

    CPC分类号: C07D499/00

    摘要: The invention relates to compounds of the formula: ##STR1## wherein R stands forBenzyl,Phenoxymethyl,4-amino-4-carboxy-1-butyl,R.sup.3 o--, r.sup.3 s--, r.sup.3 r.sup.4 n-- whereinR.sup.3 is loweralkyl, aryl or arylloweralkyl,R.sup.4 is hydrogen or R.sup.3, andR.sup.2 is hydrogen or methoxy, andR.sup.1 is hydrogen or a cleavable radical such as--CH.sub.2 OCH.sub.3, loweralkyl, 2,2,2-trichloroethyl, benzyl, p-nitrobenzyl, benzhydryl, phenacyl or trimethylsilyl. The novel compounds are useful intermediates in the preparation of known penicillin and cephalosporin derivatives.

    摘要翻译: 本发明涉及下式的化合物:其中R代表苄基,苯氧基甲基,4-氨基-4-羧氧基-1-丁基,R3O-,R3S-,R3R4N-,其中R3是低级烷基,芳基或芳基低级烷基,R4 是氢或R3,R2是氢或甲氧基,R1是氢或可分解的基团,例如-CH2OCH3,低级烷基,2,2,2-三氯乙基,苄基,对硝基苄基,二苯甲基,苯甲酰甲基或三甲基甲硅烷基。 该新化合物是制备已知青霉素和头孢菌素衍生物的有用中间体。

    Thiazoleneazetidinones from dithiazeneazetidinones
    2.
    发明授权
    Thiazoleneazetidinones from dithiazeneazetidinones 失效
    噻吩并氮杂环丁酮的噻唑烷并氮杂环丁酮

    公开(公告)号:US4091026A

    公开(公告)日:1978-05-23

    申请号:US622627

    申请日:1975-10-15

    IPC分类号: C07D499/00 C07D513/04

    CPC分类号: C07D513/04 C07D499/00

    摘要: An improved process for preparing 4-thia-2,6-diazabicyclo[3,2,0]hept-2-ene-7-ones such as methyl 3-phenoxy-4-thia-2,6-diazabicyclo[3,2,0]hept-2-ene-7-one-6-isopropenylacetate which comprises extruding sulfur from dithiazeneazetidinones such as methyl 3-phenoxymethyl-4,5-dithia-2,7-diazabicyclo[4,2,0]-oct-2-ene-8-one-7-isopropenylacetate. The compounds obtained are useful intermediates in the preparation of certain 3-cephems.

    摘要翻译: 制备4-硫杂-2,6-二氮杂双环[3,2,0]庚-2-烯-7-酮的改进方法,例如3-苯氧基-4-硫杂-2,6-二氮杂双环[3,2 ,0]庚-2-烯-7-酮-6-异丙烯基乙酸酯,其包括从二苯并氮杂环丁酮如3-苯氧基甲基-4,5-二硫杂-2,7-二氮杂双环[4,2,0] - 辛烷 -2-烯-8-酮-7-基丙酸乙酯。 获得的化合物是制备某些3-口香糖的有用的中间体。

    1,2,4-Dithiaaz-3-enes
    3.
    发明授权

    公开(公告)号:US4006139A

    公开(公告)日:1977-02-01

    申请号:US571427

    申请日:1975-04-24

    CPC分类号: C07D499/00

    摘要: The invention relates to compounds of the formula: ##STR1## wherein R stands for benzyl, phenoxymethyl, 4-amino-4-carboxy-1-butyl, R.sup.3 O--, R.sup.3 S--, R.sup.3 R.sup.4 N-- wherein R.sup.3 is loweralkyl, aryl or arylloweralkyl, R.sup.4 is hydrogen or R.sup.3, and OH when the radicals R.sup.3 O--, R.sup.3 S-- and R.sup.3 R.sup.4 N--are hydrolyzed; R.sup. 2 is hydrogen or methoxy, and R.sup.1 is hydrogen or a cleavable radical such as --CH.sub.2 OCH.sub.3, loweralkyl, 2,2,2-trichloroethyl, benzyl, p-nitrobenzyl, benzhydryl, phenoxyethyl or trimethylsilyl. The novel compounds are useful intermediates in the preparation of known penicillin and cephalosporin derivatives.

    摘要翻译: 本发明涉及下式的化合物:其中R代表苄基,苯氧基甲基,4-氨基-4-羧基-1-丁基,R3O-,R3S-,R3R4N-,其中R3是低级烷基,芳基或芳基低级烷基,R4 当基团R3O-,R3S-和R3R4N-被水解时,是氢或R3,OH; R 2为氢或甲氧基,R 1为氢或可分解的基团,例如-CH 2 OCH 3,低级烷基,2,2,2-三氯乙基,苄基,对硝基苄基,二苯甲基,苯氧基乙基或三甲基甲硅烷基。 该新化合物是制备已知青霉素和头孢菌素衍生物的有用中间体。