公开(公告)号：US06228881B1

公开(公告)日：2001-05-08

申请号：US09461446

申请日：1999-12-14

Applicant: John R. Regan ,  Pier F. Cirillo ,  Eugene R. Hickey ,  Neil Moss ,  Charles L. Cywin ,  Christopher Pargellis ,  Thomas A. Gilmore

Inventor： John R. Regan ,  Pier F. Cirillo ,  Eugene R. Hickey ,  Neil Moss ,  Charles L. Cywin ,  Christopher Pargellis ,  Thomas A. Gilmore

IPC: A61K3138

CPC classification number: C07D235/30 ,  C07D231/40 ,  C07D333/36

Abstract: Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are therefore useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.

Abstract translation: 新型芳香杂环化合物抑制参与免疫调节和炎症的细胞因子生成，如白细胞介素-1和肿瘤坏死因子的产生。 因此，化合物可用于治疗涉及炎症的疾病或病理状况的药物组合物，例如慢性炎性疾病。

公开(公告)号：US20050032797A1

公开(公告)日：2005-02-10

申请号：US10940898

申请日：2004-09-14

Applicant: Pier Cirillo ,  Abdelhakim Hammach ,  Victor Kamhi ,  Neil Moss ,  Paul Riska ,  Christopher Pargellis

Inventor： Pier Cirillo ,  Abdelhakim Hammach ,  Victor Kamhi ,  Neil Moss ,  Paul Riska ,  Christopher Pargellis

IPC: C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D401/12 ,  C07D405/12 ,  C07D521/00 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/506 ,  C07D413/04 ,  C07D43/04

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D239/34 ,  C07D239/47 ,  C07D239/52 ,  C07D401/12 ,  C07D405/12

Abstract: Disclosed are compounds of formula(I): wherein R1, R2, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Abstract translation: 公开了式（I）的化合物：其中式（I）的R 1，R 2，W和X在本文中定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US07279475B2

公开(公告)日：2007-10-09

申请号：US10940898

申请日：2004-09-14

Applicant: Pier Francesco Cirillo ,  Abdelhakim Hammach ,  Victor Kamhi ,  Neil Moss ,  Paul S Riska ,  Christopher Pargellis

Inventor： Pier Francesco Cirillo ,  Abdelhakim Hammach ,  Victor Kamhi ,  Neil Moss ,  Paul S Riska ,  Christopher Pargellis

IPC: A61K31/5377 ,  A61K31/496 ,  C07D413/06 ,  C07D403/06

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D239/34 ,  C07D239/47 ,  C07D239/52 ,  C07D401/12 ,  C07D405/12

Abstract: Disclosed are compounds of formula(I): wherein R1, R2, W and X of formula(I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Abstract translation: 公开了式（I）的化合物：其中式（I）的R 1，R 2，W和X如本文所定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US20070203141A1

公开(公告)日：2007-08-30

申请号：US11742975

申请日：2007-05-01

Applicant: Peter Grob ,  Jeffrey Madwed ,  Christopher Pargellis ,  Chan Yong

Inventor： Peter Grob ,  Jeffrey Madwed ,  Christopher Pargellis ,  Chan Yong

IPC: A61K31/5375

CPC classification number: A61K31/5377 ,  Y02A50/401

Abstract: Disclosed are methods of administering BIRB 796 BS, a p38 MAPK inhibitor, at particular dosages.

Abstract translation: 公开了以特定剂量施用BIRB 796 BS（一种p38MAPK抑制剂）的方法。

公开(公告)号：US06872726B2

公开(公告)日：2005-03-29

申请号：US10632998

申请日：2003-08-01

Applicant: Pier Francesco Cirillo ,  Abdelhakim Hammach ,  Victor Kamhi ,  Neil Moss ,  Paul S. Riska ,  Christopher Pargellis

Inventor： Pier Francesco Cirillo ,  Abdelhakim Hammach ,  Victor Kamhi ,  Neil Moss ,  Paul S. Riska ,  Christopher Pargellis

IPC: C07D239/34 ,  C07D239/46 ,  C07D239/52 ,  C07D401/12 ,  C07D405/12 ,  C07D521/00 ,  A61K31/505 ,  C07D239/24

CPC classification number: C07D249/08 ,  C07D231/12 ,  C07D233/56 ,  C07D239/34 ,  C07D239/47 ,  C07D239/52 ,  C07D401/12 ,  C07D405/12

Abstract: Disclosed are compounds of formula (I): wherein R1, R2, W and X of formula (I) are defined herein. The compounds inhibit production of cytokines involved in inflammatory processes and are thus useful for treating diseases and pathological conditions involving inflammation such as chronic inflammatory disease. Also disclosed are processes for preparing these compounds and pharmaceutical compositions comprising these compounds.

Abstract translation: 公开了式（I）的化合物：其中式（I）的R 1，R 2，W和X在本文中定义。 该化合物抑制涉及炎症过程的细胞因子的产生，因此可用于治疗涉及诸如慢性炎性疾病的炎症的疾病和病理状况。 还公开了制备这些化合物的方法和包含这些化合物的药物组合物。

公开(公告)号：US6080763A

公开(公告)日：2000-06-27

申请号：US181743

申请日：1998-10-29

Applicant: John R. Regan ,  Pier F. Cirillo ,  Eugene R. Hickey ,  Neil Moss ,  Charles L. Cywin ,  Christopher Pargellis ,  Thomas A. Gilmore

Inventor： John R. Regan ,  Pier F. Cirillo ,  Eugene R. Hickey ,  Neil Moss ,  Charles L. Cywin ,  Christopher Pargellis ,  Thomas A. Gilmore

IPC: A61K31/381 ,  A61K31/415 ,  A61K31/4184 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  A61K31/4439 ,  A61K31/4725 ,  A61P29/00 ,  C07D231/40 ,  C07D235/30 ,  C07D333/36 ,  C07D401/04 ,  C07D401/12 ,  C07D405/12 ,  C07D409/04 ,  A61K31/44 ,  C07D231/38

CPC classification number: C07D235/30 ,  C07D231/40 ,  C07D333/36

Abstract: Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are therefore useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.