公开(公告)号：US07935837B2

公开(公告)日：2011-05-03

申请号：US12112229

申请日：2008-04-30

Applicant: Nai-Hsuan Hsu ,  Chu-Yi Pang ,  Chien-Jen Wu ,  Chi-Jen Huang ,  Chia-Jung Hsu ,  Peimin Lee

Inventor： Nai-Hsuan Hsu ,  Chu-Yi Pang ,  Chien-Jen Wu ,  Chi-Jen Huang ,  Chia-Jung Hsu ,  Peimin Lee

IPC: C07J3/00

CPC classification number: C07J3/00

Abstract: A process for synthesis of androstane 17-β carbothioic acid is provided. The process includes mixing an androstane 17-β carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-β carbothioic acid, wherein the androstane 17-β carbothioic acid has the formula (I): wherein R1 represents hydrogen or haloalkyl groups, R2 represents C1-8 linear alkyl groups, C1-8 branched alkyl groups, C1-6 unsaturated acyclic groups or aromatic groups, R3 represents hydrogen or hydroxyl, R4 represents hydrogen, bromine, chlorine or fluorine and R5 represents hydrogen, bromine, chlorine or fluorine. The process is a one-pot reaction.

Abstract translation: 雄甾烷17-＆bgr的合成方法 提供硫代酸。 该方法包括混合雄甾烷17-和bgr; 羧酸和偶联剂，并加入链烷硫醚以形成雄甾烷17-和bgr; 硫代硫酸，其中雄甾烷17-＆bgr; 硫代硫酸具有式（I）：其中R 1表示氢或卤代烷基，R 2表示C 1-8直链烷基，C 1-8支链烷基，C 1-6不饱和非环基或芳基，R 3表示氢或羟基，R 4 表示氢，溴，氯或氟，R5表示氢，溴，氯或氟。 该过程是一锅反应。

公开(公告)号：US20090275767A1

公开(公告)日：2009-11-05

申请号：US12112229

申请日：2008-04-30

Applicant: Nai-Hsuan Hsu ,  Chu-Yi Pang ,  Chien-Jen Wu ,  Chi-Jen Huang ,  Chia-Jung Hsu ,  Peimin Lee

Inventor： Nai-Hsuan Hsu ,  Chu-Yi Pang ,  Chien-Jen Wu ,  Chi-Jen Huang ,  Chia-Jung Hsu ,  Peimin Lee

IPC: C07J3/00

CPC classification number: C07J3/00

Abstract: A process for synthesis of androstane 17-β carbothioic acid is provided. The process includes mixing an androstane 17-β carboxylic acid and a coupling reagent, and adding an alkanethioic acid to form an androstane 17-β carbothioic acid, wherein the androstane 17-β carbothioic acid has the formula (I): wherein R1 represents hydrogen or haloalkyl groups, R2 represents C1-8 linear alkyl groups, C1-8 branched alkyl groups, C1-6 unsaturated acyclic groups or aromatic groups, R3 represents hydrogen or hydroxyl, R4 represents hydrogen, bromine, chlorine or fluorine and R5 represents hydrogen, bromine, chlorine or fluorine. The process is a one-pot reaction.

Abstract translation: 提供了一种合成雄甾烷17-β硫代硫酸的方法。 该方法包括混合雄甾烷17-β羧酸和偶联剂，并加入链烷硫酸以形成雄甾烷17-β硫代硫酸，其中雄甾烷17-β-硫代酸具有式（I）：其中R1表示氢 或卤代烷基，R 2表示C 1-8直链烷基，C 1-8支链烷基，C 1-6不饱和非环基或芳基，R 3表示氢或羟基，R 4表示氢，溴，氯或氟，R 5表示氢， 溴，氯或氟。 该过程是一锅反应。