公开(公告)号：US20160153994A1

公开(公告)日：2016-06-02

申请号：US14896261

申请日：2014-06-10

Applicant: JPT Peptide Technologies GmbH ,  Chartié-Universitatsmedizin Berlin (Charité)

Inventor： Carmen Scheibenbogen ,  Hans-Dieter Volk ,  Josef Priller ,  Klemens Ruprecht ,  Ulf Reimer ,  Holger Wenschuh

IPC: G01N33/569 ,  C12Q1/70

CPC classification number: G01N33/56994 ,  C12Q1/705 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N2333/05 ,  G01N2469/10

Abstract: The present invention relates to an in vitro method for diagnosing Chronic Fatigue Syndrome by determining the presence, absence or the amount of at least one marker characteristic of an Epstein-Barr virus (EBV) infection in a sample obtained from the body of an individual. Specifically, the marker characteristic of EBV infection is selected from the group consisting of EBNA1, EBNA3, EBNA4, EBNA6, BZLF1, LMP1 and VP26. Furthermore, the invention relates to a device for the diagnosis of Chronic Fatigue Syndrome, wherein the device comprises a solid phase having immobilized thereon at least one marker or protein fragment thereof, wherein the marker is selected from the group consisting of EBNA1, EBNA3, EBNA4, EBNA6, BZLF1, LMP1 and VP26. In addition, the invention relates to the use of at least one marker or a protein fragment thereof for diagnosis of Chronic Fatigue, wherein the marker is selected from the group consisting of EBNA1 EBNA3, EBNA4, EBNA6, BZLF1, LMP1 and VP26.

Abstract translation: 本发明涉及一种用于诊断慢性疲劳综合症的体外方法，其通过确定从个体的体内获得的样品中至少一种爱泼斯坦 - 巴尔病毒（EBV）感染特征的特征的存在，不存在或数量。 具体地，EBV感染的标记特征选自EBNA1，EBNA3，EBNA4，EBNA6，BZLF1，LMP1和VP26。 此外，本发明涉及用于诊断慢性疲劳综合征的装置，其中该装置包括其上固定有至少一个标记物或蛋白质片段的固相，其中所述标记选自EBNA1，EBNA3，EBNA4 ，EBNA6，BZLF1，LMP1和VP26。 此外，本发明涉及至少一种标志物或其蛋白质片段用于诊断慢性疲劳的用途，其中所述标志物选自EBNA1 EBNA3，EBNA4，EBNA6，BZLF1，LMP1和VP26。