公开(公告)号：US20110224414A1

公开(公告)日：2011-09-15

申请号：US13130130

申请日：2009-11-23

Applicant: Shuguang Wang ,  Jin Zhong ,  Deyun Kong ,  Jue Hu ,  Bo Li ,  Wen Gao ,  Chunyan Gai ,  Changiong Zhuang ,  Haitao Mao

Inventor： Shuguang Wang ,  Jin Zhong ,  Deyun Kong ,  Jue Hu ,  Bo Li ,  Wen Gao ,  Chunyan Gai ,  Changiong Zhuang ,  Haitao Mao

IPC: C07H15/24 ,  C07C309/44 ,  C07C49/675

CPC classification number: A61K31/122 ,  A61K31/185 ,  A61K31/192 ,  A61K31/7004 ,  A61K31/704 ,  A61K36/482 ,  A61K36/708 ,  A61K36/74

Abstract: Use of 9,10-anthraquinone compounds of formula (I) or pharmaceutical salts thereof or plant extracts containing said compounds in the preparation of anti-HCV medicaments is disclosed, in which Y1 are Y2 are independently hydrogen, hydroxyl or groups of formula (II); and R1, R2, R3, R4, R5 and R6 are independently hydrogen, hydroxyl, carboxyl, cyano group, nitro group, groups of formula (III) or groups selected from those substituted or unsubstituted groups: amino, C1-C6 aliphatic hydrocarbon, C3-C7 cyclic aliphatic hydrocarbon, C1-C6 alkoxy, C2-C7 carbalkoxy, C1-C4 acyloxy, C6-C20 aryl, or 5 to 7 members heterocyclic or benzoheterocyclic thereof; or R5 and R6 form the group of formula (IV). The compounds of present invention are cheap, safe and effective, because that they mostly conic from traditional Chinese medicines and have better anti-HCV effects and lighter side effects.

Abstract translation: 公开了在制备抗HCV药物中使用式（I）的9,10-蒽醌化合物或其药用盐或含有所述化合物的植物提取物，其中Y 1为Y 2独立地为氢，羟基或式（II ）; 并且R 1，R 2，R 3，R 4，R 5和R 6独立地是氢，羟基，羧基，氰基，硝基，式（III）的基团或选自那些取代或未取代的基团的基团：氨基，C 1 -C 6脂族烃， C 3 -C 7环脂族烃，C 1 -C 6烷氧基，C 2 -C 7烷酰氧基，C 1 -C 4酰氧基，C 6 -C 20芳基或5至7元杂环或苯并杂环; 或R 5和R 6形成式（IV）的基团。 本发明化合物廉价，安全有效，因为它们大多是中药复方，抗HCV效果更好，副作用更轻。