公开(公告)号：US11919854B2

公开(公告)日：2024-03-05

申请号：US17042806

申请日：2019-03-29

申请人： Centre national de la recherche scientifique ,  CHRU de Lille ,  Universite Côte D'Azur ,  Institut National de la Sante et de la Recherche Medicale (INSERM) ,  Université de Lille ,  YNCREA Hauts de France

发明人： Valérie Vouret ,  Laetitia Douguet ,  Alina Ghinet ,  Germain Homerin ,  Benoît Guy Marie Rigo ,  Davy Jérémy Baudelet ,  Xavier Dezitter ,  Régis Millet ,  Christophe Furman

IPC分类号： C07D207/16 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4439 ,  A61K39/395 ,  A61P1/00 ,  A61P35/00 ,  C07D401/12 ,  C07D409/12

CPC分类号： C07D207/16 ,  A61K31/4015 ,  A61K31/4025 ,  A61K31/4439 ,  A61K39/395 ,  A61P1/00 ,  A61P35/00 ,  C07D401/12 ,  C07D409/12

摘要： The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the treatment of cancer or inflammatory diseases.

公开(公告)号：US20240327354A1

公开(公告)日：2024-10-03

申请号：US18579953

申请日：2022-07-22

申请人： INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE ,  INSTITUT PASTEUR DE LILLE ,  UNIVERSITÉ DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  CHRU DE LILLE ,  JOHANN WOLFGANG GOETHE-UNIVERSITÄT FRANKFURT AM MAIN

发明人： Anaïs VIEIRA DA CRUZ ,  Coline PLÉ ,  Marion FLIPO ,  Nina COMPAGNE ,  Nicolas WILLAND ,  Heng-Keat TAM ,  Juan Carlos JIMÉNEZ CASTELLANOS ,  Klaas Martinus POS ,  Ruben Christiaan HARTKOORN ,  Reinke Tobias MÜLLER

IPC分类号： C07D213/74 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/496 ,  A61K31/498 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D213/80 ,  C07D215/38 ,  C07D217/22 ,  C07D241/44 ,  C07D295/073 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/08

CPC分类号： C07D213/74 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/495 ,  A61K31/496 ,  A61K31/498 ,  A61K31/55 ,  A61K31/551 ,  A61K45/06 ,  C07D213/80 ,  C07D215/38 ,  C07D217/22 ,  C07D241/44 ,  C07D295/073 ,  C07D401/04 ,  C07D413/04 ,  C07D471/04 ,  C07D471/08 ,  C07D487/08

摘要： The present invention concerns novel Gram-negative bacteria efflux pump inhibitors. It further relates to the use of Gram-negative bacteria efflux pump inhibitors to prevent and/or treat antibiotic resistance by potentiating the activity of antibiotics. Infections by multidrug resistant (MDR) Gram-negative bacteria are a major threat to global healthcare. The inventors have discovered a novel class of Resistance Nodulation cell Division-efflux pump inhibitors. The inventors tested the effects of these inhibitors on growth inhibition of different bacteria as well as their impact on the boosting of antibiotic activity in different bacteria. Particularly, the inventors tested the effects of these inhibitors on E. coli, A. baumamnii, K. pneumoniae and P. aeruginosa.

公开(公告)号：US12042179B2

公开(公告)日：2024-07-23

申请号：US17251807

申请日：2019-06-13

申请人： CHRU DE LILLE

发明人： Chrystèle Rubod ,  Michel Cosson ,  Estelle Jean ,  Franck Gaultier ,  Mathias Brieu

IPC分类号： A61B17/44 ,  A61B17/00

CPC分类号： A61B17/44 ,  A61B2017/00119 ,  A61B2017/00221 ,  A61B2017/445

摘要： An assistance device and an associated obstetrical instrument, in particular of the forceps type, for extracting a fetus during childbirth having two branches. Each branch being equipped at one end with a gripping handle and at the other end with cephalic blades. The instrument further includes a measurement device using the blades and connector between the measurement device and the blade. The measurement device includes: a pressure measurement instrument configured to measure the pressure exerted by the blade on the fetus, a position measuring instrument to measure the positioning of the obstetrical instrument, a power supply, and a transmitter configured to transmit the measurements to a processing unit.

公开(公告)号：US20210113242A1

公开(公告)日：2021-04-22

申请号：US17251807

申请日：2019-06-13

申请人： CHRU DE LILLE

发明人： CHRYSTÈLE RUBOD ,  MICHEL COSSON ,  ESTELLE JEAN ,  FRANCK GAULTIER ,  MATHIAS BRIEU

IPC分类号： A61B17/44

摘要： An assistance device and an associated obstetrical instrument, in particular of the forceps type, for extracting a fetus during childbirth having two branches. Each branch being equipped at one end with a gripping handle and at the other end with cephalic blades. The instrument further includes a measurement device using the blades and connector between the measurement device and the blade. The measurement device includes: a pressure measurement instrument configured to measure the pressure exerted by the blade on the fetus, a position measuring instrument to measure the positioning of the obstetrical instrument, a power supply, and a transmitter configured to transmit the measurements to a processing unit.

公开(公告)号：US20210017131A1

公开(公告)日：2021-01-21

申请号：US17042806

申请日：2019-03-29

申请人： Centre national de la recherche scientifique ,  CHRU de Lille ,  Universite Côte D'Azur ,  Institut National de la Sante et da la Recherche Medicale (INSERM) ,  Université de Lille ,  YNCREA Hauts de France

发明人： Valérie Vouret ,  Laetitia Douguet ,  Alina Ghinet ,  Germain Homerin ,  Benoît Guy Marie Rigo ,  Davy Jérémy Baudelet ,  Xavier Dezitter ,  Régis Millet ,  Christophe Furman

IPC分类号： C07D207/16 ,  C07D401/12 ,  C07D409/12 ,  A61K39/395 ,  A61K31/4439 ,  A61K31/4025 ,  A61K31/4015 ,  A61P1/00 ,  A61P35/00

摘要： The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the prevention and/or treatment of cancer or inflammatory diseases.