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公开(公告)号：US20230144322A1
公开(公告)日：2023-05-11
申请号：US18149981
申请日：2023-01-04
CPC分类号： A61K51/0489 , C07F9/2458 , C07F9/58 , A61K51/0402 , C07F9/2404 , C07F9/2416
摘要： Compounds of Marlush formula (I) described in the claims are useful in diagnostic methods for detecting and/or identifying cells presenting PSMA. Disclosed are also methods for preparing the compounds. Representative compounds according to the application are:
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公开(公告)号：US20200061218A1
公开(公告)日：2020-02-27
申请号：US16349756
申请日：2017-11-24
发明人： Clifford Berkman , Cindy Choy
IPC分类号： A61K49/10 , C07D225/08
摘要： Provided herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof, wherein L1 and L2 are each independently a covalent bond or a divalent linking group, R is a detectable label or therapeutic drug and B is an albumin binding moiety. Also provided are compositions including a compound of Formula (I) together with a pharmaceutically acceptable carrier, and methods for imaging prostate cancer cells using a compound of Formula (I).
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公开(公告)号：US20170072075A1
公开(公告)日：2017-03-16
申请号：US15246483
申请日：2016-08-24
IPC分类号： A61K51/04 , C07F9/6561 , C07F9/6524
CPC分类号： A61K51/0489 , A61K49/04 , A61K51/0497 , C07B59/004 , C07B2200/05 , C07F9/2458 , C07F9/6515 , C07F9/6524 , C07F9/6527 , C07F9/65583 , C07F9/6561
摘要： Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells.
摘要翻译： 提供了本文定义的化合物，其可用于（1）用于检测和/或鉴定呈现PSMA的细胞的诊断方法; （2）包含本发明化合物和药学上可接受的稀释剂的组合物; 和（3）前列腺癌细胞成像方法。
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公开(公告)号：US20190309000A1
公开(公告)日：2019-10-10
申请号：US16316567
申请日：2017-08-10
发明人： Clifford Berkman , Cindy Choy
IPC分类号： C07F9/6561 , C07F9/6524 , C07F9/24 , C07F9/553 , A61K51/04
摘要： Provided herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. Also provided are compositions including a compound of Formula (I) together with a pharmaceutically acceptable carrier, and methods for imaging prostate cancer cells.
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公开(公告)号：US09974869B2
公开(公告)日：2018-05-22
申请号：US15246483
申请日：2016-08-24
IPC分类号： A61K51/04 , A61K49/04 , C07B59/00 , C07F9/24 , C07F9/6515 , C07F9/6524 , C07F9/6527 , C07F9/6558 , C07F9/6561
CPC分类号： A61K51/0489 , A61K49/04 , A61K51/0497 , C07B59/004 , C07B2200/05 , C07F9/2458 , C07F9/6515 , C07F9/6524 , C07F9/6527 , C07F9/65583 , C07F9/6561
摘要： Compounds as defined herein are provided which are useful in (1) diagnostic methods for detecting and/or identifying cells presenting PSMA; (2) compositions comprising a compound of the invention together with a pharmaceutically acceptable diluent; and (3) methods for imaging prostate cancer cells.
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公开(公告)号：US20160030605A1
公开(公告)日：2016-02-04
申请号：US14774371
申请日：2014-03-14
CPC分类号： A61K51/0489 , A61K51/0402 , C07F9/2404 , C07F9/2416 , C07F9/2458 , C07F9/58
摘要： Compounds of Marlush formula (I) described in the claims are useful in diagnostic methods for detecting and/or identifying cells presenting PSMA. Disclosed are also methods for preparing the compounds. Representative compounds according to the application are:
摘要翻译： 权利要求中描述的Marlush式（I）化合物可用于检测和/或鉴定呈现PSMA的细胞的诊断方法。 还公开了制备化合物的方法。 根据应用的代表性化合物是：
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公开(公告)号：US11225496B2
公开(公告)日：2022-01-18
申请号：US16316567
申请日：2017-08-10
发明人： Clifford Berkman , Cindy Choy
IPC分类号： A61K51/00 , A61M36/14 , C07F9/6561 , A61K51/04 , C07F9/24 , C07F9/553 , C07F9/6524
摘要： Provided herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. Also provided are compositions including a compound of Formula (I) together with a pharmaceutically acceptable carrier, and methods for imaging prostate cancer cells.
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公开(公告)号：US20230064292A1
公开(公告)日：2023-03-02
申请号：US17759754
申请日：2021-01-29
摘要： The invention relates to methods of treating cancer with CTT1403 having specificity for prostate-specific membrane antigen (PSMA).
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公开(公告)号：US11554183B2
公开(公告)日：2023-01-17
申请号：US14774371
申请日：2014-03-14
摘要： Compounds of Marlush formula (I) described in the claims are useful in diagnostic methods for detecting and/or identifying cells presenting PSMA. Disclosed are also methods for preparing the compounds. Representative compounds according to the application are:
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公开(公告)号：US20220162241A1
公开(公告)日：2022-05-26
申请号：US17528571
申请日：2021-11-17
发明人： Clifford Berkman , Cindy Choy
IPC分类号： C07F9/6561 , A61K51/04 , C07F9/24 , C07F9/553 , C07F9/6524
摘要： Provided herein are compounds of Formula (I) or a pharmaceutically acceptable salt thereof. Also provided are compositions including a compound of Formula (I) together with a pharmaceutically acceptable carrier, and methods for imaging prostate cancer cells.
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