公开(公告)号：US07709484B1

公开(公告)日：2010-05-04

申请号：US11110060

申请日：2005-04-19

申请人： Shubh D. Sharma ,  Yi-Qun Shi ,  Zhijun Wu ,  Bolun Hu ,  Ramesh Rajpurohit

发明人： Shubh D. Sharma ,  Yi-Qun Shi ,  Zhijun Wu ,  Bolun Hu ,  Ramesh Rajpurohit

IPC分类号： A61K31/497 ,  C07D241/04 ,  C07D403/04 ,  C07D405/04 ,  C07D295/04

CPC分类号： C07D241/04 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12

摘要： A substituted piperazine compound having the structure I: or the structure IX: or an enantomeric, stereoisomeric or diastereomeric form of the foregoing, and pharmaceutically acceptable salts thereof, where J, L, Q, W, A, R6, R7, z and y are as defined in the specification, and the carbon atoms marked with an asterisk can have any stereochemical configuration, which compounds bind to one or more melanocortin receptors and may be employed in pharmaceutical preparations for treatment of one or more melanocortin receptor-associated conditions or disorders, and methods for the use of the compounds of the invention.

摘要翻译： 其中J，L，Q，W，A，R6，R7，z和y具有结构I或结构IX的取代哌嗪化合物或其前体的烯醇，立体异构体或非对映体形式及其药学上可接受的盐 标记有星号的碳原子可以具有任何立体化学构型，该化合物结合一种或多种黑皮质素受体并可用于治疗一种或多种黑皮质素受体相关病症或病症的药物制剂中 以及使用本发明化合物的方法。