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1.发明申请ANTIMICROBIAL FILLED CAPSULES IN AN ULTRASOUND FIELD FOR TREATMENT OF DENTAL BIOFILM 失效用于治疗牙齿生物膜的超声波填充胶囊中的抗微生物填充胶囊公开(公告)号：US20100269281A1
公开(公告)日：2010-10-28
申请号：US12808254
申请日：2008-12-09
IPC分类号： A46B9/04
CPC分类号： A61C17/20 , A46B15/0002 , A46B15/0028 , A46B2200/1066 , A61C17/0202 , A61C17/22 , A61C17/227 , A61K8/11 , A61K2800/82 , A61Q11/00
摘要： An appliance and corresponding method for delivering antimicrobial agents to the vicinity of dental biofilm and for killing bacteria therein includes a system (18, 20, 24) for delivering polymeric capsules containing gas bubbles and an antimicrobial agent. A source of ultrasonic energy (18) is provided for moving the capsules toward the biofilm, the ultrasonic energy having sufficient intensity for thereafter bursting the capsules, in the vicinity of the biofilm, releasing the gas bubbles and the agent. The gas bubbles vibrate within the ultrasound field, disrupting the biofilm, so that the released agent can act effectively against the bacteria in the disrupted biofilm.
摘要翻译： 用于将抗微生物剂递送到牙齿生物膜附近并用于杀死细菌的器具和相应方法包括用于递送含有气泡的聚合物胶囊和抗微生物剂的系统（18,20,24）。 提供超声波能量源（18），用于将胶囊朝向生物膜移动，超声能量具有足够的强度，此后使生物膜附近的胶囊爆裂，释放出气泡和药剂。 气泡在超声波场内振动，破坏了生物膜，使得释放的试剂能够有效地对抗破坏的生物膜中的细菌。
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公开(公告)号：US20100063490A1
公开(公告)日：2010-03-11
申请号：US12305438
申请日：2007-06-21
申请人： Rieko Verhagen , Robbert A.M. Van Hal , Bart Gottenbos , Jozef J.M. Janssen , Paul A.J. Ackermans , Francisco Morales Serrano , Sieglinde Nerken , Dirk Brokken , Guido Roosen
发明人： Rieko Verhagen , Robbert A.M. Van Hal , Bart Gottenbos , Jozef J.M. Janssen , Paul A.J. Ackermans , Francisco Morales Serrano , Sieglinde Nerken , Dirk Brokken , Guido Roosen
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B5/1077 , A61B5/442 , A61B18/20 , A61B90/361 , A61B2017/00057 , A61B2017/00106 , A61B2017/00154 , A61B2018/00452 , A61B2018/0047 , A61B2018/00666 , A61B2018/00904 , A61B2018/20351
摘要： The invention provides a skin treatment device comprising a laser source (40) and focusing optics (50), such that a focal spot (18) is positioned in a dermis layer (24) of the skin to be treated. The laser beam (42) is powered and focused (16) such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (30). The device may comprise wrinkle-determining means (52, 54, 56, 58). The focusing optics (50) may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (30), by providing a focused laser beam (16) that causes LIOB in the dermis layer (24) of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.
摘要翻译： 本发明提供一种皮肤治疗装置，其包括激光源（40）和聚焦光学元件（50），使得焦点（18）位于待治疗皮肤的真皮层（24）中。 激光束（42）被供电并聚焦（16），使得获得LIOB（激光诱导光学击穿）现象，其影响皮肤以刺激组织的再生长。 这反过来又减少皱纹（30）。 该装置可以包括皱纹确定装置（52,54,56,58）。 聚焦光学元件（50）可以具有至少0.4的数值孔径。 本发明还提供了一种相应的治疗皮肤的方法，特别是通过提供在皮肤真皮层（24）中引起LIOB的聚焦激光束（16）来减少皱纹（30）。 优点是可以通过使用非常局部的LIOB现象来避免覆盖表皮层的损伤。
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公开(公告)号：US08668660B2
公开(公告)日：2014-03-11
申请号：US12808251
申请日：2008-12-09
CPC分类号： A61C17/0202
摘要： The interproximal cleaning appliance includes a housing (12) and a spray applicator (16) extending therefrom for directing a spray of fluid droplets to the interproximal area. Within the housing is a spray-generating assembly (14) which includes a chamber, a movable piston (26) mounted therein, one-way inlets (42, 40) for gas and fluid and an outlet (44). A system (54) for moving the piston, such as a motor, operatively compresses a spring (32) which creates a partial vacuum in the chamber, allowing gas to flow into the chamber through the gas inlet. Release of the spring produces a stream of fluid droplets which flows out of the chamber through the applicator to the interproximal area.
摘要翻译： 所述邻间清洁器具包括从其延伸的壳体（12）和喷洒器（16），用于将流体液滴喷射到所述邻间区域。 在壳体内是喷射发生组件（14），其包括腔室，安装在其中的可移动活塞（26），用于气体和流体的单向入口（42,40）和出口（44）。 用于使活塞（例如电动机）移动的系统（54）可操作地压缩在腔室中产生部分真空的弹簧（32），允许气体通过气体入口流入腔室。 弹簧的释放产生流过液滴的流体流，通过涂布器流出到邻近区域。
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公开(公告)号：US20120083731A1
公开(公告)日：2012-04-05
申请号：US13377303
申请日：2010-06-09
申请人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
发明人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
IPC分类号： A61M1/06
CPC分类号： A61M1/066
摘要： An insert for a breast-receiving funnel (10) of a breast pump comprising an elongate inflatable bladder (23) which defines a pressure chamber (26), the elongate inflatable bladder (23) being adapted to fit in a teat receiving space (11) of said breast receiving funnel (10) so that the bladder extends from an inner end of said funnel towards an outer end of said funnel, and lie between a user's teat and the funnel when a breast is inserted in the funnel, such that the elongate inflatable bladder is configured to deform towards a user's teat located in the teat receiving space in a predetermined manner when a pressure difference is applied between the teat receiving space and the pressure chamber such that a peristaltic action is applied to said user's teat, to aid the expression of milk therefrom.
摘要翻译： 一种用于乳房接收漏斗（10）的插入物，其包括限定压力室（26）的细长的可充气气囊（23），所述细长的可充气囊（23）适于装配在奶嘴接收空间（11 ），使得所述囊从所述漏斗的内端朝向所述漏斗的外端延伸，并且当乳房插入漏斗中时，位于使用者的乳头和漏斗之间，使得 细长的可充气囊被构造成当在奶头接收空间和压力室之间施加压力差时以预定的方式朝着位于奶头接收空间内的使用者的奶头变形，使得蠕动动作施加到所述使用者的乳头，以帮助 牛奶的表达。
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5.发明申请公开(公告)号：US20100221196A1
公开(公告)日：2010-09-02
申请号：US12672710
申请日：2008-05-08
CPC分类号： A61K8/042 , A61K8/736 , A61K2800/5426 , A61Q11/00
摘要： The method for cleaning dental plaque biofilm from the teeth includes the steps of applying a liquid gellable composition to the teeth, the composition including a positively charged polymer such as chitosan, the liquid composition having a viscosity which results in coverage of substantially all of the exposed areas of the teeth. The liquid composition is then gelled by the addition of a second composition, such as a negatively charged compound. The resulting gelled composition has an adherence to the plaque biofilm which is greater than the adherence between the biofilm and the teeth. The gel layer with the biofilm is peeled off of the teeth, removing the dental plaque.
摘要翻译： 用于从牙齿清洁牙斑生物膜的方法包括以下步骤：向牙齿施加液体可胶凝组合物，所述组合物包含带正电荷的聚合物，例如壳聚糖，所述液体组合物具有导致基本上所有暴露的 牙齿区域 然后通过加入第二组合物如带负电荷的化合物使液体组合物凝胶化。 所得凝胶组合物对斑块生物膜的粘附性大于生物膜和牙齿之间的粘附。 将具有生物膜的凝胶层从牙齿上剥离，去除牙菌斑。
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公开(公告)号：US20090305187A1
公开(公告)日：2009-12-10
申请号：US12374505
申请日：2007-07-06
申请人： Jozef Johannes Maria Janssen , Bart Gottenbos , Luciana Opran , Petrus Henricus De Leeuw , Dirk Brokken , Arjan Leo Van Der Sande
发明人： Jozef Johannes Maria Janssen , Bart Gottenbos , Luciana Opran , Petrus Henricus De Leeuw , Dirk Brokken , Arjan Leo Van Der Sande
IPC分类号： A61C17/02
CPC分类号： A61C17/0217 , A61C17/0202 , A61C17/028
摘要： The interdental cleaner includes a source of liquid (22) and a control system (42) including a manual pump (26), for moving a selected amount of liquid, suitable for a single use, into a liquid pathway and there to a mixing chamber (53). A source of pressurized gas (30), such as a CO2 cartridge, is used to preload a selected amount of gas into a gas chamber (52). The control system includes a spring-loaded button (18), which upon operation results in the manual pump (26) being operated, forcing the selected amount of liquid into the mixing chamber, and then upon release, permits the pressurized gas in the gas chamber to enter the mixing chamber, breaking up the liquid therein into droplets and a liquid stream, and propelling the resulting liquid out of a nozzle portion (14) of the cleaner into the interproximal area of the teeth.
摘要翻译： 齿间清洁器包括液体源（22）和包括手动泵（26）的控制系统（42），用于将选定量的适于一次使用的液体移动到液体通道中，并且到达混合室 （53）。 使用诸如CO 2筒的加压气体源（30）将选定量的气体预加载到气室（52）中。 控制系统包括弹簧加载按钮（18），其在操作时导致手动泵（26）被操作，迫使选定量的液体进入混合室，然后在释放时允许气体中的加压气体 室进入混合室，将其中的液体分解为液滴和液体流，并将所得液体从吸尘器的喷嘴部分（14）推出到齿的邻近区域中。
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7.发明申请SYSTEMS AND METHODS FOR CARDIAC ABLATION USING LASER INDUCED OPTICAL BREAKDOWN 审中-公开使用激光诱导光学断裂进行心脏吸收的系统和方法公开(公告)号：US20090198223A1
公开(公告)日：2009-08-06
申请号：US12297012
申请日：2007-04-02
申请人： Rachel Estelle Thilwind , Robbert Adrianus Maria van Hal , Rieko Verhagen , Paul Anton Josef Ackermans , Dirk Brokken , Jozef J.M. Janssen , Bart Gottenbos , Sieglinde Neerken , Francisco Morales Serrano
发明人： Rachel Estelle Thilwind , Robbert Adrianus Maria van Hal , Rieko Verhagen , Paul Anton Josef Ackermans , Dirk Brokken , Jozef J.M. Janssen , Bart Gottenbos , Sieglinde Neerken , Francisco Morales Serrano
CPC分类号： A61B18/24 , A61B2017/00243 , A61B2018/2266
摘要： Systems and methods for achieving sub-surface, highly spatially selective cardiac ablation by means of laser induced optical breakdown (LIOB) are disclosed. Damage to non-targeted heart and artery/vein tissue is to be minimized according to the present disclosure. A catheter enters the heart, e.g., via a vein, and catheter location is determined/confirmed. Laser pulses are guided through the optical path within the catheter and, at or near the catheter end, a focusing structure is provided that focuses the laser radiation through the non-targeted vein/heart tissue into the targeted tissue. In the focusing structure, laser induced LIOB occurs and related mechanical effects affect the targeted tissue.
摘要翻译： 公开了通过激光诱导光学击穿（LIOB）实现子表面，高度空间选择性心脏消融的系统和方法。 根据本公开，要使对非靶向心脏和动脉/静脉组织的损伤最小化。 导管例如通过静脉进入心脏，并且确定/确认导管位置。 激光脉冲被引导通过导管内的光路，并且在导管末端处或附近提供聚焦结构，其将激光辐射通过非靶向静脉/心脏组织聚焦到目标组织中。 在聚焦结构中，激光诱导的LIOB发生并且相关的机械效应影响目标组织。
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公开(公告)号：US20080311540A1
公开(公告)日：2008-12-18
申请号：US12094187
申请日：2006-10-27
IPC分类号： A61C1/07
摘要： A method of removing bio films from a surface is disclosed. The method includes a source of bubbles in a liquid medium being provided. The bubbles having a predetermined size. A source of ultrasound waves at a predetermined frequency also being provided. The bubbles in the liquid medium being output toward the surface. The ultrasound waves also being directed toward the surface so that the bubbles vibrate at the predetermined frequency of the ultrasound waves. The predetermined size of the bubbles is approximately related to the frequency of the ultrasound waves.
摘要翻译： 公开了从表面去除生物膜的方法。 该方法包括提供液体介质中的气泡源。 具有预定尺寸的气泡。 还提供了预定频率的超声波源。 液体介质中的气泡朝向表面输出。 超声波也朝向表面，使得气泡以超声波的预定频率振动。 气泡的预定大小近似与超声波的频率有关。
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公开(公告)号：US08821482B2
公开(公告)日：2014-09-02
申请号：US12305438
申请日：2007-06-21
申请人： Rieko Verhagen , Robbert Adrianus Maria Van Hal , Bart Gottenbos , Jozef Johannes Maria Janssen , Paul Anton Josef Ackermans , Francisco Morales Serrano , Sieglinde Neerken , Dirk Brokken , Guido Roosen
发明人： Rieko Verhagen , Robbert Adrianus Maria Van Hal , Bart Gottenbos , Jozef Johannes Maria Janssen , Paul Anton Josef Ackermans , Francisco Morales Serrano , Sieglinde Neerken , Dirk Brokken , Guido Roosen
IPC分类号： A61B18/18
CPC分类号： A61B18/203 , A61B5/1077 , A61B5/442 , A61B18/20 , A61B90/361 , A61B2017/00057 , A61B2017/00106 , A61B2017/00154 , A61B2018/00452 , A61B2018/0047 , A61B2018/00666 , A61B2018/00904 , A61B2018/20351
摘要： The invention provides a skin treatment device comprising a laser source (40) and focusing optics (50), such that a focal spot (18) is positioned in a dermis layer (24) of the skin to be treated. The laser beam (42) is powered and focused (16) such that a LIOB (laser induced optical breakdown) phenomenon is obtained, which affects the skin in order to stimulate re-growth of tissue. This in turn reduces wrinkles (30). The device may comprise wrinkle-determining means (52, 54, 56, 58). The focusing optics (50) may have a numerical aperture of at least 0.4. The invention also provides a corresponding method to treat skin, in particular to reduce wrinkles (30), by providing a focused laser beam (16) that causes LIOB in the dermis layer (24) of the skin. The advantage is that damage to overlaying epidermis layers may be avoided by the use of the very local LIOB phenomenon.
摘要翻译： 本发明提供一种皮肤治疗装置，其包括激光源（40）和聚焦光学元件（50），使得焦点（18）位于待治疗皮肤的真皮层（24）中。 激光束（42）被供电并聚焦（16），使得获得LIOB（激光诱导光学击穿）现象，其影响皮肤以刺激组织的再生长。 这反过来又减少皱纹（30）。 该装置可以包括皱纹确定装置（52,54,56,58）。 聚焦光学元件（50）可以具有至少0.4的数值孔径。 本发明还提供了一种相应的治疗皮肤的方法，特别是通过提供在皮肤真皮层（24）中引起LIOB的聚焦激光束（16）来减少皱纹（30）。 优点是可以通过使用非常局部的LIOB现象来避免覆盖表皮层的损伤。
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公开(公告)号：US08684961B2
公开(公告)日：2014-04-01
申请号：US13377303
申请日：2010-06-09
申请人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
发明人： Bart Gottenbos , Rachel Estelle Thilwind , Jozef Johannes Maria Janssen , Marjolein Irene Van Lieshout
IPC分类号： A61M1/06
CPC分类号： A61M1/066
摘要： An insert for a breast-receiving funnel of a breast pump includes an elongate inflatable bladder which defines a pressure chamber. The elongate inflatable bladder is configured to fit in a teat receiving space of the breast receiving funnel so that the bladder extends from an inner end of the funnel towards an outer end of the funnel. The bladder lies between a user's teat and the funnel when a breast is inserted in the funnel, such that the elongate inflatable bladder is configured to deform towards a user's teat located in the teat receiving space in a predetermined manner when a pressure difference is applied between the teat receiving space and the pressure chamber such that a peristaltic action is applied to the user's teat, to aid the expression of milk therefrom.
摘要翻译： 用于吸乳器的乳房接收漏斗的插入件包括限定压力室的细长的可充气囊。 细长的可充气囊被构造成装配在乳房容纳漏斗的奶嘴接收空间中，使得囊从漏斗的内端朝向漏斗的外端延伸。 当乳房插入漏斗中时，膀胱位于使用者的乳头和漏斗之间，使得细长的可充气气囊被配置成在预定方式上朝向位于乳头接收空间中的使用者乳头变形时， 乳头接收空间和压力室，使得蠕动作用施加于使用者的乳头，以帮助从其中表达牛奶。
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