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公开(公告)号：US10358439B2
公开(公告)日：2019-07-23
申请号：US15759884
申请日：2016-09-16
Applicant: Board of Regents, The University of Texas System , Board of Regents, The University of Texas System
Inventor： Waldemar Priebe , Liwei Guo , Arkadiusz Kazimierski , Izabela Fokt , Charles Conrad , Timothy Madden
IPC: C07C13/66 , C07D309/14 , C07D405/12 , C07D405/14 , C07H15/24 , C07H15/244 , A61P35/00
Abstract: Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung, or pancreatic cancer, are also provided herein.
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公开(公告)号：US20180251454A1
公开(公告)日：2018-09-06
申请号：US15759884
申请日：2016-09-16
Applicant: Board of Regents, The University of Texas System , Board of Regents, The University of Texas System
Inventor： Waldemar PRIEBE , Liwei GUO , Arkadiusz KAZIMIERSKI , Izabela FOKT , Charles CONRAD , Timothy MADDEN
IPC: C07D405/14 , C07D405/12 , A61P35/00
CPC classification number: C07D405/14 , A61P35/00 , C07C13/66 , C07D309/14 , C07D405/12 , C07H15/24 , C07H15/244
Abstract: Provided herein are compounds which intercalate into the DNA of a cell and are capable of crossing the blood brain barrier of a formula provided herein. Pharmaceutical compositions of the compounds and methods of treating cancer, for example brain, lung, or pancreatic cancer, are also provided herein.
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公开(公告)号：US20250062738A1
公开(公告)日：2025-02-20
申请号：US18807407
申请日：2024-08-16
Inventor： Ruochen Lu , Jack Kramer , Sinwoo Cho , Omar Barrera , Vakhtang Chulukhadze
Abstract: Exemplary multimeter-wave acoustic resonators and methods employing intermediate layers in the fabricating of piezoelectric devices based on thin-film lithium niobate/lithium tantalate or aluminum nitride/scandium aluminum nitride on a substrate in a film stack that can use higher order first and third antisymmetric bulk acoustic tones. In some embodiments, the acoustic resonator comprises a base substrate of a material with low electromagnetic loss, a piezoelectric film layer that is suspended over the base substrate, and an interdigitated electrode (IDE) array formed by a pair of independently addressable microelectrode arrays disposed on a top surface of the piezoelectric film layer to resonantly vibrate at a range of frequencies greater than 6 GHz. The piezoelectric film layer was formed over an intermediate or sacrificial layer positioned between the base substrate and the piezoelectric film layer and then etched to provide the piezoelectric film layer suspended over the base substrate.
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公开(公告)号：US20250062042A1
公开(公告)日：2025-02-20
申请号：US18449468
申请日：2023-08-14
Applicant: ABILENE CHRISTIAN UNIVERSITY , GEORGIA TECH RESEARCH CORPORATION , The Texas A&M University System , Board of Regents, The University of Texas System
Inventor： Derek Haas , Jordan Robison , Steven Biegalski , Timothy Head , Rusty Towell , Kevin Clarno , Bojan Petrovic , Pavel Tsvetkov , Jonathan Scherr , Mark Kimber
Abstract: An integral molten salt nuclear reactor includes a drain tank section configured to hold a volume of fuel salt. The integral molten salt nuclear reactor further includes a reactor section configured to receive the volume of fuel salt from the drain tank and cause fission reactions that heats the molten salt. The integral molten salt nuclear reactor further includes a heat exchange section configured to receive a flow of the heated fuel salt from the reactor section and remove heat therefrom.
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公开(公告)号：US20250059282A1
公开(公告)日：2025-02-20
申请号：US18936765
申请日：2024-11-04
Inventor： Michael A. CURRAN , Ashvin R. JAISWAL , Dongxing ZHA , Carlo TONIATTI , Bianka PRINZ , Nadthakarn BOLAND , Eric KRAULAND
IPC: C07K16/28 , A61K39/00 , G01N33/569 , G01N33/68
Abstract: The present disclosure is directed to bispecific antibodies which bind to both PD-L1 and PD-L2, and methods of using such antibodies to treat cancers, such as those that express or overexpress PD-L1, PD-L2, or both.
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Patent Agency Ranking
公开(公告)号：US20250059272A1
公开(公告)日：2025-02-20
申请号：US18583340
申请日：2024-02-21
Inventor： Jean X. Jiang , Manuel A. Riquelme , Sumin Gu
Abstract: Methods for identifying compounds that positively regulate connexin 43 hemichannels.
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公开(公告)号：US12227806B2
公开(公告)日：2025-02-18
申请号：US17472740
申请日：2021-09-13
Inventor： Jonathan C. Cohen , Helen H. Hobbs
IPC: C12Q1/68 , C12Q1/6883
Abstract: The invention relates generally to an allele on human chromosome 9 associated with increased risk for coronary heart disease and the use or detection of such an allele in determining whether a human has an increased risk for coronary heart disease. In one aspect, the invention relates to methods for detecting a predisposition or propensity or susceptibility for coronary heart disease in a human, comprising detecting the presence of an allele on human chromosome 9 that is associated with an increased risk for coronary heart disease in a human. Disclosed are methods and compositions for determining whether a person carries an allele associated with increased risk for coronary atherosclerosis by determining whether the person has an RA-CHR9 allele, such as by determining whether the person has an RA-CHR9 allele-associated single nucleotide polymorphism (SNP). The invention also relates to kits for detecting the presence of an allele on chromosome 9 associated with an increased risk for coronary heart disease.
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公开(公告)号：US12226571B2
公开(公告)日：2025-02-18
申请号：US17234544
申请日：2021-04-19
Inventor： Benjamin G. Johnson , Michelle Colleen Cole , Chase Christenson , Mikayla Li Rahman , Teja Guda
Abstract: The present invention provides an apparatus for detection of ventilator associated pneumonia (VAP) in a patient, the apparatus comprising: an endotracheal tube; at least two non-selective electrode contacts located in proximity to each other within the endotracheal tube, the contacts lacking any structural feature or component that particularly recognizes a chemical or biological species; an electrical subsystem that is capable of generating, receiving and processing electrical signals; wiring for connecting each of the electrode contacts with the electrical subsystem; and tubing for insulating the wiring from any sputum material that is introduced into the endotracheal tube by the patient.
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公开(公告)号：US12226404B2
公开(公告)日：2025-02-18
申请号：US17836067
申请日：2022-06-09
Inventor： Robert O. Williams, III , Keith P. Johnston , Prapasri Sinswat , Jason T. McConville , Robert Talbert , Jay I. Peters , Alan B. Watts , True L. Rogers
IPC: A61K31/436 , A61K9/00 , A61K9/16 , A61K9/19 , A61K9/51 , A61K38/13 , A61P11/00 , A61P37/00 , A61P37/06
Abstract: The present invention includes compositions and methods for making and using a rapid dissolving, high potency, substantially amorphous nanostructured aggregate for pulmonary delivery of tacrolimus and a stabilizer matrix comprising, optionally, a polymeric or non-polymeric surfactant, a polymeric or non-polymeric saccharide or both, wherein the aggregate comprises a surface area greater than 5 m2/g as measured by BET analysis and exhibiting supersaturation for at least 0.5 hours when 11-15-times the aqueous crystalline solubility of tacrolimus is added to simulated lung fluid.
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公开(公告)号：US20250054648A1
公开(公告)日：2025-02-13
申请号：US18795873
申请日：2024-08-06
Applicant: ABILENE CHRISTIAN UNIVERSITY , GEORGIA TECH RESEARCH CORPORATION , The Texas A&M University System , Board of Regents, The University of Texas System
Inventor： Ryan Kelly , Steven Biegalski , Ryan Brownfield , Kraig Farrar , Tyler Gates , Derek Haas , Jonathan Scherr , Jack Shoemate , Pavel Tsvetkov
IPC: G21C17/108 , G01T3/00 , G01T7/00
Abstract: A method and system for calibrating nuclear instrumentation of a reactor is disclosed. The system comprises a reactor configured to operate at a low power level and an external heater configured to heat the reactor to its operating temperature and maintain the reactor in a critical state. The reactor maintains its temperature at a steady state by repeating steps of reducing the heater's power and increasing the reactor's power by changing one or more reactivity settings, wherein the reduced heater's power is compensated by using the increased power generated by the reactor itself. The nuclear instrumentation is configured to measure the reactor's output power and compare it with the calculated reactor's power. Based on the discrepancy between the calculated power and the measured power exceeds a threshold; and the nuclear instrumentation is appropriately calibrated by adjusting one or more settings.
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