公开(公告)号：US20240158420A1

公开(公告)日：2024-05-16

申请号：US18547609

申请日：2021-03-17

Applicant: FIVE ELEVEN PHARMA, INC ,  BIOMOLECULAR PROBES BIOTECHNOLOGY (BEIJING) CO., LTD

Inventor： Hank F KUNG ,  Zhihao ZHA ,  Karl PLOESSL ,  Seok Rye CHOI ,  David ALEXOFF

IPC: C07F5/06 ,  G01N33/574 ,  G01N33/68

CPC classification number: C07F5/069 ,  G01N33/57434 ,  G01N33/68

Abstract: A radiopharmaceuticals in clinical popularization is facilitated. By means of the biological characteristic of specifically targeting PSMA of the [18F]AlF-P16-093, the labeled product has important potential clinical values in the aspects of early diagnosis, preoperative staging, treatment guidance, recurrence and metastasis focus detection of prostate cancer.

公开(公告)号：US20240139350A1

公开(公告)日：2024-05-02

申请号：US18263722

申请日：2021-02-01

Applicant: FIVE ELEVEN PHARMA, INC ,  BIOMOLECULAR PROBES BIOTECHNOLOGY (BEIJING) CO., LTD

Inventor： Hank F KUNG ,  Zhihao ZHA ,  Karl PLOESSL ,  Seok Rye CHOI ,  David ALEXOFF

IPC: A61K51/04

CPC classification number: A61K51/0455 ,  A61K2123/00

Abstract: A radioactively labeled ligand for a fibroblast activation protein-alpha imaging agent and a preparation method therefor are provided. The radioactively labeled ligand for the fibroblast activation protein-alpha imaging agent has structural formal (I). The compound has a good 68Ga labeling property, a high stability and a good affinity for FAP tumors. The radioactively labeled ligand for 68Ga-labeled FAPi can be used as a tumor positron imaging agent.