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公开(公告)号：US12226616B2
公开(公告)日：2025-02-18
申请号：US18415452
申请日：2024-01-17
Applicant: Ascendis Pharma A/S
Inventor： Per Mølgaard Pedersen , Flemming Madsen , Sven Erik Poulsen , Steen Jensen , Henrik Egesborg
Abstract: Disclosed is an auto injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge assembly comprising a cartridge and a cartridge code feature, the cartridge containing the medicament; a code sensor configured to read the cartridge code feature; a drive module coupled to move a plunger rod; and a processing unit coupled to the code sensor and the drive module. The processing unit being configured to: receive from the code sensor a code signal indicative of the cartridge code feature; control the drive module to move the plunger rod to a first plunger rod position, the first plunger rod position being based on the code signal; receive a trigger event; control the drive module to move the plunger rod to a second plunger rod position following reception of the trigger event.
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公开(公告)号：US11896671B2
公开(公告)日：2024-02-13
申请号：US16317689
申请日：2017-07-12
Applicant: Ascendis Pharma A/S
Inventor： Nicola Bisek , Samuel Weisbrod , Kornelia Bigott
CPC classification number: A61K47/545 , A61K47/542 , A61K47/60 , A61K47/61 , A61K47/64
Abstract: The present invention relates to reagents comprising a substituted acyl borate or a substituted hydroxylamine, to a method of synthesizing a carrier-linked prodrug using said reagents and to carrier-linked prodrugs obtainable by said method.
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公开(公告)号：US11738147B2
公开(公告)日：2023-08-29
申请号：US17829161
申请日：2022-05-31
Applicant: Ascendis Pharma A/S
Inventor： Jan Olesen , Flemming Madsen
CPC classification number: A61M5/20 , A61M5/24 , A61M5/3202 , A61M2005/2411 , A61M2205/50 , A61M2205/502 , A61M2205/82 , A61M2205/8206 , A61M2205/8237 , A61M2205/8262
Abstract: An auto injector is disclosed comprising: a housing, a cartridge receiver, and an ejector member. The cartridge receiver is configured to receive a cartridge containing the medicament. The auto injector further comprises a blocking member coupled to an ejector member. The blocking member is configured to move between a blocking position wherein a connector opening is blocked and a non-blocking position wherein the connector opening is not blocked.
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公开(公告)号：US20230241217A1
公开(公告)日：2023-08-03
申请号：US17923314
申请日：2021-05-03
Applicant: Ascendis Pharma A/S
Inventor： Oliver Boris STAUCH , Sebastian STARK , Tobias VOIGT , Nicola BISEK
CPC classification number: A61K41/17 , A61K47/60 , A61K47/6903
Abstract: The present invention relates to a process for the irradiation of a water-insoluble conjugate comprising a polymer Z to which a plurality of moieties -L2-L1-D is covalently conjugated or of a water-insoluble complex comprising a plurality of releasably and non-covalently bound drug molecules D-H or D-OH embedded in a polymer Z′, wherein the process comprises the steps of (a) providing said conjugate or complex; and (b) exposing the conjugate or complex to ionizing radiation; wherein each -L2- is independently a chemical bond or is a spacer moiety; each -L1- is independently a linker moiety covalently and reversibly attached to -D; and each -D is independently a drug moiety.
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公开(公告)号：US20230110994A1
公开(公告)日：2023-04-13
申请号：US17790589
申请日：2020-12-30
Applicant: Ascendis Pharma A/S
Inventor： Samuel WEISBROD
IPC: A61K47/68
Abstract: The present invention relates to conjugates and pharmaceutically acceptable salts thereof, reagents, intermediates, methods for the synthesis of said conjugates, pharmaceutical compositions comprising said conjugates and the use of said conjugates.
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Patent Agency Ranking
公开(公告)号：US20230072178A1
公开(公告)日：2023-03-09
申请号：US17985438
申请日：2022-11-11
Applicant: Ascendis Pharma A/S
Inventor： Thorben Kvisgaard Jacobsen , Jan Olesen
Abstract: An auto injector (4) for administering injection of a medicament from a cartridge containing the medicament, the auto injector (4) comprising: a housing (6); a cartridge receiver (300) with a cartridge receiver compartment (302) configured to receive a cartridge assembly (600), with at least one cartridge retention member (808), when inserted through a cartridge receiver opening (301) along a longitudinal axis (L) in a receiving direction; wherein the cartridge receiver (300) has a passage (316) through which the at least one cartridge retention member (808) travels at least in the receiving direction, and a member (312) preventing movement beyond a retention position in a direction opposite of the receiving direction; an elongated ejector (200) that is configured with: an ejector support face (204) for supporting the cartridge or cartridge assembly (600), a longitudinal ejector slot (228) extending towards the ejector support face (204) from an ejector rest portion (206); wherein the elongated ejector (200) is suspended to move along the longitudinal direction and is spring-loaded in the direction opposite of the receiving direction; and an ejector lock (212) supported for turning at least a fraction of a revolution and maintained in a longitudinal position relative to the housing (6); wherein the ejector lock (212) has a ejector lock support portion (214) that is configured to align with and slide along the longitudinal ejector slot (228) at a first angle and to be brought to align with the ejector rest portion (206) at a second angle.
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公开(公告)号：US20210338834A1
公开(公告)日：2021-11-04
申请号：US17280760
申请日：2019-09-25
Applicant: Ascendis Pharma A/S
Inventor： Sebastian STARK , Burkhardt LAUFER , Thomas KNAPPE , Tobias VOIGT , Nicola BISEK
Abstract: The present invention relates to conjugates comprising crosslinked hyaluronic acid to which a plurality of drug moieties are covalently and reversibly conjugated, wherein the hyaluronic acid exhibits a certain degree of modification and comprises degradable crosslinked moieties. It also relates to their use as medicaments and their use in the diagnosis, prevention and treatment of diseases.
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公开(公告)号：US20180369483A1
公开(公告)日：2018-12-27
申请号：US16060608
申请日：2016-12-29
Applicant: Ascendis Pharma A/S
Inventor： Jan Olesen , Flemming Madsen
Abstract: An auto injector is disclosed comprising: a housing, a cartridge receiver, and an ejector member. The cartridge receiver is configured to receive a cartridge containing the medicament. The auto injector further comprises a blocking member coupled to an ejector member. The blocking member is configured to move between a blocking position wherein a connector opening is blocked and a non-blocking position wherein the connector opening is not blocked.
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公开(公告)号：US20180369482A1
公开(公告)日：2018-12-27
申请号：US16060606
申请日：2016-12-29
Applicant: Ascendis Pharma A/S
Inventor： Per Mølgaard Pedersen , Flemming Madsen , Sven Erik Poulsen , Steen Jensen , Henrik Egesborg
Abstract: Disclosed is an auto injector for administering a medicament. The auto injector comprising: a housing; a cartridge receiver configured to receive a cartridge assembly comprising a cartridge (700) and a cartridge code (1000) feature, the cartridge containing the medicament; a code sensor configured to read the cartridge code feature; a drive module coupled to move a plunger rod; and a processing unit coupled to the code sensor and the drive module. The processing unit being configured to: receive from the code sensor a code signal indicative of the cartridge code feature; control the drive module to move the plunger rod to a first plunger rod position, the first plunger rod position being based on the code signal; receive a trigger event; control the drive module to move the plunger rod to a second plunger rod position following reception of the trigger event.
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公开(公告)号：US20160082123A1
公开(公告)日：2016-03-24
申请号：US14786481
申请日：2014-04-16
Applicant: ASCENDIS PHARMA A/S
Inventor： Harald RAU , Nora KALUZA , Ulrich HERSEL , Thomas KNAPPE , Burkhardt LAUFER
IPC: A61K47/48
CPC classification number: A61K47/48784 , A61K47/60 , A61K47/6903
Abstract: The present invention relates to a process for the preparation of a hydrogel-linked prodrug releasing a tag moiety-biologically active moiety conjugate, to a hydrogel-linked prodrug releasing a tag moiety-bio logically active moiety conjugate obtainable by such process, to pharmaceutical compositions comprising said prodrug and their use as a medicament.
Abstract translation: 本发明涉及一种制备水凝胶连接的前体药物，释放标签部分 - 生物活性部分缀合物的方法，其涉及将通过这种方法获得的标签部分生物逻辑活性部分缀合物释放到药物组合物上的水凝胶连接的前药 包括所述前药及其作为药物的用途。
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