公开(公告)号：US12037407B2

公开(公告)日：2024-07-16

申请号：US18311856

申请日：2023-05-03

申请人： Arsenal Biosciences, Inc.

发明人： Jasper Williams ,  Michelle Nguyen ,  Anzhi Yao ,  Stephen Santoro ,  Aaron Cooper ,  John Gagnon ,  Adam Litterman ,  Omar Khan ,  Natalie Bezman ,  Katherine Harris ,  Harbani Kaur Malik Chaudhry ,  Nicole Allen

IPC分类号： C07K16/28 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61P35/00 ,  C07K16/2896 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

摘要： Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

公开(公告)号：US20230340139A1

公开(公告)日：2023-10-26

申请号：US18311856

申请日：2023-05-03

申请人： Arsenal Biosciences, Inc.

发明人： Jasper Williams ,  Michelle Nguyen ,  Anzhi Yao ,  Stephen Santoro ,  Aaron Cooper ,  John Gagnon ,  Adam Litterman ,  Omar Khan ,  Natalie Bezman ,  Katherine Harris ,  Harbani Kaur Malik Chaudhry ,  Nicole Allen

IPC分类号： C07K16/28 ,  A61P35/00

CPC分类号： C07K16/2878 ,  C07K16/2896 ,  A61P35/00 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

摘要： Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

公开(公告)号：US20230192843A1

公开(公告)日：2023-06-22

申请号：US18046213

申请日：2022-10-13

申请人： TENEOBIO, INC. ,  ARSENAL BIOSCIENCES, INC.

发明人： Katherine HARRIS ,  Harbani Kaur MALIK CHAUDHRY ,  Nicole ALLEN

IPC分类号： C07K16/28 ,  A61P35/00

CPC分类号： C07K16/28 ,  A61P35/00 ,  C07K16/2809 ,  A61K39/00 ,  C07K2317/31 ,  C07K2317/622

摘要： Single domain antibodies which specifically bind to mesothelin (MSLN) and mesothelin binding proteins, anti-mesothelin antibodies and antibody fragments thereof, antibody-drug conjugates, synthetic immune receptors, and diagnostic agents comprising the same are disclosed. Also disclosed are pharmaceutical compositions comprising any of the foregoing and uses of any of the foregoing in the treatment and/or diagnosis and/or monitoring of a disease associated with MSLN expression.

公开(公告)号：US20240309106A1

公开(公告)日：2024-09-19

申请号：US18677547

申请日：2024-05-29

申请人： Arsenal Biosciences, Inc.

发明人： Jasper Williams ,  Michelle Nguyen ,  Anzhi Yao ,  Stephen Santoro ,  Aaron Cooper ,  John Gagnon ,  Adam Litterman ,  Omar Khan ,  Natalie Bezman ,  Katherine Harris ,  Harbani Kaur Malik Chaudhry ,  Nicole Allen

IPC分类号： C07K16/28 ,  A61P35/00

CPC分类号： C07K16/2878 ,  A61P35/00 ,  C07K16/2896 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76

摘要： Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

公开(公告)号：US20230365997A1

公开(公告)日：2023-11-16

申请号：US18308481

申请日：2023-04-27

申请人： Arsenal Biosciences, Inc.

发明人： Aaron Cooper ,  Angela Boroughs ,  Pei-Ken Hsu

IPC分类号： C12N15/90 ,  C12N15/11 ,  C12N9/22 ,  A61P35/00 ,  A61K39/00

CPC分类号： C12N15/907 ,  A61K39/4611 ,  A61K39/4631 ,  A61P35/00 ,  C12N9/22 ,  C12N15/11 ,  C12N2310/20 ,  C12N2800/80

摘要： Provided herein are compositions and methods for producing genomically edited cells expressing an exogenous transgene and restored or continued expression of an endogenous gene. Methods of using the genomically edited cells for treating or preventing a disease in a subject are also provided.

公开(公告)号：US11761004B2

公开(公告)日：2023-09-19

申请号：US17716816

申请日：2022-04-08

申请人： Arsenal Biosciences, Inc.

发明人： Xinying Zheng ,  Brendan Galvin ,  Somya Khare ,  Aaron Cooper ,  Michelle Nguyen ,  Anzhi Yao

IPC分类号： C12N15/113 ,  A61K35/17 ,  C12N5/0783 ,  C12N15/11 ,  C12N9/22 ,  C12N15/85

CPC分类号： C12N15/1136 ,  A61K35/17 ,  C12N5/0636 ,  C12N9/22 ,  C12N15/111 ,  C12N15/85 ,  C12N2310/20

摘要： Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

公开(公告)号：US20220235380A1

公开(公告)日：2022-07-28

申请号：US17689837

申请日：2022-03-08

申请人： Arsenal Biosciences, Inc.

发明人： Jasper Williams ,  Michelle Nguyen ,  Anzhi Yao ,  Stephen Santoro ,  Aaron Cooper ,  John Gagnon ,  Adam Litterman ,  Omar Khan ,  Natalie Bezman

IPC分类号： C12N15/90 ,  C07K14/725 ,  C07K14/705 ,  C12N9/22 ,  C12N15/85 ,  A61P35/00

摘要： Provided herein are recombinant nucleic acids encoding chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX. Also provided are systems of chimeric priming receptors that bind ALPG/P, chimeric antigen receptors that bind MSLN, and shRNA that target FAS, PTPN2, and/or TOX, cells expressing such proteins and shRNA, and methods of use thereof.

公开(公告)号：US20220127616A1

公开(公告)日：2022-04-28

申请号：US17239484

申请日：2021-04-23

申请人： Arsenal Biosciences, Inc.

发明人： Xinying Zheng ,  Brendan Galvin ,  Somya Khare ,  Aaron Cooper ,  Michelle Nguyen ,  Anzhi Yao

IPC分类号： C12N15/113 ,  A61K35/17 ,  C12N5/0783 ,  C12N15/85 ,  C12N15/11 ,  C12N9/22

摘要： Provided herein are safe harbor loci and methods for identifying and using safe harbor loci to engineer cells to express transgenes. The safe harbor loci exhibit increased transgene knock-in efficiency and allow for increased, stable expression of transgenes in engineered cells. Guide ribonucleic acids (gRNAs) may be used for insertion of transgenes in the safe harbor loci.

公开(公告)号：US20240342284A1

公开(公告)日：2024-10-17

申请号：US18593711

申请日：2024-03-01

申请人： Arsenal Biosciences, Inc.

发明人： Angela Boroughs ,  Levi Gray-Rupp ,  Samuel A. Williams ,  Zhen Jian Zhou ,  Matthew Drever ,  Duy Nguyen ,  Amy-Jo Casbon ,  Anzhi Yao ,  Thomas Gardner

IPC分类号： A61K39/00 ,  A61P35/00 ,  C07K14/725 ,  C07K16/30 ,  C07K16/40 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC分类号： A61K39/464495 ,  A61K39/4631 ,  A61K39/464454 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/3069 ,  C07K16/40 ,  C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C07K2317/31 ,  C12N2310/20

摘要： Provided herein are antibodies and chimeric priming receptors that bind PSMA and antibodies and chimeric antigen receptors that bind CA9. Also provided are systems of chimeric priming receptors that bind PSMA and chimeric antigen receptors that bind CA9, cells expressing such systems, and methods of use thereof.

公开(公告)号：US20240240164A1

公开(公告)日：2024-07-18

申请号：US18379912

申请日：2023-10-13

申请人： Arsenal Biosciences, Inc.

发明人： Aaron Cooper ,  Pei-Ken Hsu ,  Robert Moot ,  Annie Truong ,  Thomas Gardner ,  Brian Hsu

IPC分类号： C12N9/22 ,  C12N15/11 ,  C12N15/90

CPC分类号： C12N9/22 ,  C12N15/11 ,  C12N15/907 ,  C12N2310/20 ,  C12N2800/80

摘要： Provided herein are compositions and methods for producing genetically engineered cells, such as T cells, with an insertion of a cassette at a designated genomic locus. Methods of using the genetically engineered cells for treating or preventing a disease in a subject are also provided.