公开(公告)号：US20110269155A1

公开(公告)日：2011-11-03

申请号：US13127136

申请日：2008-11-03

申请人： Sine Reker-Hadrup ,  Arnold Hendrik Bakker ,  Cheng Yi Jenny Shu ,  Antonius Nicolaas Maria Schumacher

发明人： Sine Reker-Hadrup ,  Arnold Hendrik Bakker ,  Cheng Yi Jenny Shu ,  Antonius Nicolaas Maria Schumacher

IPC分类号： G01N33/566 ,  C07K7/06

CPC分类号： G01N33/56972 ,  G01N33/58

摘要： The present invention relates to methods for detecting antigen responsive cells in a sample using multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (NHC). Further, the present invention relates to the use of the present multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (MHC), for detecting antigen responsive cells in a sample, preferably a single sample, such as a blood sample. The present method allows high-throughput analysis of specific antigen responsive cells, such as T- and B-cells, thereby providing, for example, high-throughput methods for monitoring of diseases or conditions and the development of immunotherapeutics, vaccines, or the identification epitopes or immunogenic amino acid sequences.

摘要翻译： 本发明涉及使用多维标记抗原呈递化合物如抗原主要组织相容性复合物（NHC）检测样品中抗原应答细胞的方法。 此外，本发明涉及本发明的多维标记抗原呈递化合物如抗原主要组织相容性复合物（MHC）用于检测样品中优选单个样品例如血液样品中的抗原应答细胞的用途。 本方法允许特异性抗原应答细胞例如T细胞和B细胞的高通量分析，从而提供例如用于监测疾病或病症的高通量方法以及发展免疫治疗剂，疫苗或鉴定 表位或免疫原性氨基酸序列。

公开(公告)号：US09151757B2

公开(公告)日：2015-10-06

申请号：US13127136

申请日：2008-11-03

申请人： Sine Reker-Hadrup ,  Arnold Hendrik Bakker ,  Cheng Yi Jenny Shu ,  Antonius Nicolaas Maria Schumacher

发明人： Sine Reker-Hadrup ,  Arnold Hendrik Bakker ,  Cheng Yi Jenny Shu ,  Antonius Nicolaas Maria Schumacher

IPC分类号： G01N33/58 ,  G01N33/569

CPC分类号： G01N33/56972 ,  G01N33/58

摘要： The present invention relates to methods for detecting antigen responsive cells in a sample using multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (NHC). Further, the present invention relates to the use of the present multidimensional labeled antigen presenting compounds, such as antigen-major histocompatibility complexes (MHC), for detecting antigen responsive cells in a sample, preferably a single sample, such as a blood sample. The present method allows high-throughput analysis of specific antigen responsive cells, such as T- and B-cells, thereby providing, for example, high-throughput methods for monitoring of diseases or conditions and the development of immunotherapeutics, vaccines, or the identification epitopes or immunogenic amino acid sequences.

摘要翻译： 本发明涉及使用多维标记抗原呈递化合物如抗原主要组织相容性复合物（NHC）检测样品中抗原应答细胞的方法。 此外，本发明涉及本发明的多维标记抗原呈递化合物如抗原主要组织相容性复合物（MHC）用于检测样品中优选单个样品例如血液样品中的抗原应答细胞的用途。 本方法允许特异性抗原应答细胞例如T细胞和B细胞的高通量分析，从而提供例如用于监测疾病或病症的高通量方法以及发展免疫治疗剂，疫苗或鉴定 抗原决定簇或免疫原性氨基酸序列。