公开(公告)号：US06387408B1

公开(公告)日：2002-05-14

申请号：US09059646

申请日：1998-04-13

Applicant: Lisbeth Illum ,  Paul Williams ,  Antony James Caston

Inventor： Lisbeth Illum ,  Paul Williams ,  Antony James Caston

IPC: A61K914

CPC classification number: A61K9/5052 ,  A61K9/167 ,  Y02A50/473

Abstract: Adhesive material from the fimbriae (esp. Type 1) of bacteria or synthetic analogues or fragments thereof is combined with a drug to provide for attachment to the gut of a mammal, thereby prolonging the transit time of the drug through the gut. The 28 kDa polypeptide from E. coli Type 1 fimbriae is the preferred adhesive material (“adhesin”). The drug is presented in a carrier such as albumin, a polylactide/glycolide copolymer or alginate microcapsules. The adhesin may be incorporated in the carrier during preparation thereof, adsorbed onto the carrier after preparation, or covalently linked thereto, for example with carbodiimide.

Abstract translation: 来自菌毛（特别是1型）的细菌或合成类似物或其片段的粘合剂材料与药物组合以提供与哺乳动物的肠道连接，从而延长药物通过肠道的通过时间。28kDa 来自大肠杆菌1型菌毛的多肽是优选的粘合剂材料（“粘附素”）。 药物存在于载体如白蛋白，聚丙交酯/乙交酯共聚物或藻酸盐微胶囊中。 粘附素可以在其制备过程中加入到载体中，在制备后吸附到载体上或与其共价连接，例如与碳二亚胺形成。

公开(公告)号：US06355276B1

公开(公告)日：2002-03-12

申请号：US08234723

申请日：1994-04-28

Applicant: Lisbeth Illum ,  Paul Williams ,  Antony James Caston

Inventor： Lisbeth Illum ,  Paul Williams ,  Antony James Caston

IPC: A61K916

CPC classification number: A61K9/5052 ,  A61K9/167 ,  Y02A50/473

Abstract: Adhesive material from the fimbriae (esp. Type 1) of bacteria or synthetic analogues or fragments thereof is combined with a drug to provide for attachment to the gut of a mammal, thereby prolonging the transit time of the drug through the gut. The 28 kDa polypeptide from E. coli Type 1 fimbriae is the preferred adhesive material (“adhesin”). The drug is presented in a carrier such as albumin, a polylactide/glycolide copolymer or alginate microcapsules. The adhesin may be incorporated in the carrier during preparation thereof, adsorbed onto the carrier after preparation, or covalently linked thereto, for example with carbodiimide.

Abstract translation: 来自细菌（特别是1型）的细菌或合成类似物或其片段的粘合剂材料与药物组合以提供与哺乳动物的肠道连接，从而延长药物通过肠道的通过时间。 来自大肠杆菌1型菌毛的28kDa多肽是优选的粘合剂材料（“粘附素”）。 药物存在于载体如白蛋白，聚丙交酯/乙交酯共聚物或藻酸盐微胶囊中。 粘附素可以在其制备过程中加入到载体中，在制备后吸附到载体上或与其共价连接，例如与碳二亚胺形成。