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公开(公告)号：US20090196913A1
公开(公告)日：2009-08-06
申请号：US12119012
申请日：2008-05-12
IPC分类号： A61K9/127 , A61K31/704 , A61P35/00
CPC分类号： A61K9/127 , A61K31/704
摘要： An immunoliposome composition targeted to the alpha-V-integrin subunit of integrin receptors comprised of ligand-targeted liposomes bearing at least one targeting-ligand derived from an antibody and having binding specificity for at least one integrin receptor comprising an alpha-V subunit including αvβ1, αvβ3 αvβ5, αvβ6, or αvβ8 integrin cell receptors is described. The antibody-derived targeting ligand may be a Fab′ fragment, a scFv, or a the like. Binding of the immunoliposome to αv-integrin expressing cells, preferably results in internalization of the immunoliposome for cytoplasmic delivery of a liposome-entrapped agent.
摘要翻译： 靶向由整合素受体组成的α-V整联蛋白亚单位的免疫脂质体组合物，其由具有至少一种衍生自抗体的靶向配体的配体靶向脂质体组成，并且对至少一种整合素受体具有结合特异性，所述整合素受体包含α-V亚基，包括alphavbeta1 ，alphavbeta3 alphavbeta5，alphavbeta6或alphavbeta8整联蛋白细胞受体。 抗体衍生的靶向配体可以是Fab'片段，scFv等。 免疫脂质体与表达表达α-融合蛋白的细胞的结合优选地导致免疫脂质体内在化，用于脂质体包裹的药物的细胞质递送。
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2.发明申请公开(公告)号：US20060269542A1
公开(公告)日：2006-11-30
申请号：US11408441
申请日：2006-04-20
申请人： Kristen Hjortsvang , Luke Guo , Frances Wong , Azar Najafi , Anthony Huang , Robert Abra , Laura Kelley
发明人： Kristen Hjortsvang , Luke Guo , Frances Wong , Azar Najafi , Anthony Huang , Robert Abra , Laura Kelley
IPC分类号： A61K39/395 , A61K9/127
CPC分类号： A61K9/1271 , A61K47/6855 , A61K47/6913
摘要： An immunoliposome composition comprised of liposomes bearing a ligand for targeting to cells expressing a growth factor receptor, such as HER2, is described. Binding of the immunoliposome to HER2-expressing cells results in internalization of the immunoliposome for cytoplasmic delivery of an entrapped drug.
摘要翻译： 描述由包含用于靶向表达生长因子受体（例如HER2）的细胞的配体的脂质体组成的免疫脂质体组合物。 免疫脂质体与HER2表达细胞的结合导致免疫脂质体内含化，用于包埋药物的细胞质递送。
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公开(公告)号：US20090092662A1
公开(公告)日：2009-04-09
申请号：US12195795
申请日：2008-08-21
申请人： Anthony Huang , Bing Luo , Jingkang Wang , Yuanpeng Zhang
发明人： Anthony Huang , Bing Luo , Jingkang Wang , Yuanpeng Zhang
CPC分类号： A61K31/69 , A61K9/1271 , A61K41/0095 , A61K47/6911
摘要： A liposome composition comprised of liposomes having a peptide boronic acid proteasome inhibitor compound entrapped in the liposomes is described. More specifically, liposomes having a compound of Formula I or II entrapped in the interior aqueous compartment are loaded with a peptide boronic acid compound, to form a boronate ester compound inside the liposomal aqueous compartment. In one embodiment, the liposomes have an outer coating of hydrophilic polymer chains and are used to treat a solid tumor in a subject.
摘要翻译： 描述了包含脂质体中包含肽硼酸蛋白酶体抑制剂化合物的脂质体的脂质体组合物。 更具体地说，将含有式I或II化合物的脂质体包埋在内部水性室中，装载有肽硼酸化合物，以在脂质体水性隔室内形成硼酸酯化合物。 在一个实施方案中，脂质体具有亲水性聚合物链的外涂层，并且用于治疗受试者中的实体瘤。
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公开(公告)号：US20050025822A1
公开(公告)日：2005-02-03
申请号：US10856559
申请日：2004-05-27
申请人： Frances Wong , Anuk Das , Jonathan Seideman , Luke Guo , Anthony Huang
发明人： Frances Wong , Anuk Das , Jonathan Seideman , Luke Guo , Anthony Huang
CPC分类号： A61K9/0078 , A61K9/127 , A61K9/1271
摘要： A method for administering a therapeutic or diagnostic agent to a subject is described. The method includes providing a suspension of liposomes comprised of one or more of vesicle-forming lipids selected from (i) a vesicle-forming lipid derivatized with a hydrophilic polymer and (ii) a neutral lipopolymer, said liposomes being associated with said therapeutic or diagnostic agent, forming an aerosol of said liposome suspension; and administering the aerosol to the subject by inhalation. The liposome formulation delivers intact liposomal particles to the respiratory tract of said subject to form a depot of therapeutic agent therein with no observable provocation of an immune response, as measured by neutrophil or macrophage cell count in the lung after administration.
摘要翻译： 描述了向受试者施用治疗剂或诊断剂的方法。 该方法包括提供脂质体的悬浮液，其由一种或多种形成囊泡的脂质组成，所述脂质体选自（i）用亲水性聚合物衍生的囊泡形成脂质和（ii）中性脂质聚合物，所述脂质体与所述治疗或诊断相关联 形成所述脂质体悬浮液的气溶胶; 并通过吸入将烟雾剂施用于受试者。 脂质体制剂将完整的脂质体颗粒递送到所述受试者的呼吸道，以在其中形成治疗剂的贮库，其中不存在可观察到的免疫应答挑衅，如通过给药后肺中的嗜中性粒细胞或巨噬细胞细胞计数所测量的。
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5.发明申请公开(公告)号：US20090092661A1
公开(公告)日：2009-04-09
申请号：US12195755
申请日：2008-08-21
申请人： Anthony Huang , Bing Luo , Jinkang Wang , Yuanpeng Zhang
发明人： Anthony Huang , Bing Luo , Jinkang Wang , Yuanpeng Zhang
IPC分类号： A61K9/127
CPC分类号： A61K9/1278 , A61K9/1271 , A61K31/69 , A61K41/0095
摘要： Liposome formulations for administration of a boronic acid compound are described. The liposomes are comprised of a phospholipid having two acyl chains with between 20-22 carbon atoms in each chain and a boronic acid compound entrapped in the liposomes. In a preferred embodiment, the boronic acid compound is in the form of a complex with meglumine.
摘要翻译： 描述了用于施用硼酸化合物的脂质体制剂。 脂质体由具有两条链中具有20-22个碳原子的两个酰基链的磷脂和包含在脂质体中的硼酸化合物构成。 在优选的实施方案中，硼酸化合物是与葡甲胺复合物的形式。
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公开(公告)号：US08834920B2
公开(公告)日：2014-09-16
申请号：US12513383
申请日：2007-12-20
IPC分类号： A61K9/127 , C07K14/705 , A61K38/00
CPC分类号： C07K14/705 , A61K38/00
摘要： Short oligopeptides are provide which are capable of binding to the epidermal growth factor receptor on the surface of human tumor cells. Methods for using the peptides as targeting moieties in more complex compositions, such as conjugates of cytoxins, and/or structures, such as liposomal structures, for the purposes of drug delivery are also provided.
摘要翻译： 提供能够结合人肿瘤细胞表面的表皮生长因子受体的短寡肽。 还提供了用于在更复杂的组合物中使用肽作为靶向部分的方法，例如用于药物递送目的的细胞毒素和/或结构（例如脂质体结构）的缀合物。
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公开(公告)号：US20120213844A1
公开(公告)日：2012-08-23
申请号：US12513383
申请日：2007-12-20
IPC分类号： A61K9/127 , A61P35/00 , A61K31/351
CPC分类号： C07K14/705 , A61K38/00
摘要： Short oligopeptides are provide which are capable of binding to the epidermal growth factor receptor on the surface of human tumor cells. Methods for using the peptides as targeting moieties in more complex compositions, such as conjugates of cytoxins, and/or structures, such as liposomal structures, for the purposes of drug delivery are also provided.
摘要翻译： 提供能够结合人肿瘤细胞表面的表皮生长因子受体的短寡肽。 还提供了用于在更复杂的组合物中使用肽作为靶向部分的方法，例如用于药物递送目的的细胞毒素和/或结构（例如脂质体结构）的缀合物。
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公开(公告)号：US20060110441A1
公开(公告)日：2006-05-25
申请号：US11261983
申请日：2005-10-28
申请人： Harry Wong , Yuanpeng Zhang , Anthony Huang
发明人： Harry Wong , Yuanpeng Zhang , Anthony Huang
IPC分类号： A61K9/127 , A61K38/13 , A61K31/7048 , A61K31/7012 , A61K31/573 , A61K31/7072 , A61K31/55 , A61K31/4706 , A61K31/337 , A61K31/4196
CPC分类号： A61K31/337 , A61K9/127 , A61K9/19 , A61K31/00 , A61K31/4196 , A61K31/4706 , A61K31/55 , A61K31/573 , A61K31/7012 , A61K31/7048 , A61K31/7072 , A61K38/13
摘要： Formulations and methods for preparing a lyophilized composition comprising liposomes comprised of an unsaturated lipid and a hydrophobic drug associated with the liposome, and a cryoprotectant in a solution at a selected concentration. The phase transition temperature of the lipid is greater than the freezing point of the solution at the selected concentration.
摘要翻译： 用于制备冻干组合物的制剂和方法，所述组合物包含由与脂质体相关的不饱和脂质和疏水性药物组成的脂质体，以及选定浓度的溶液中的冷冻保护剂。 脂质的相变温度大于所选浓度下溶液的凝固点。
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