公开(公告)号：US20190209489A1

公开(公告)日：2019-07-11

申请号：US15866450

申请日：2018-01-09

申请人： Aleksandra Niedzwiecki ,  Matthias W. Rath ,  Anna Goc ,  Waldemar Sumera

发明人： Aleksandra Niedzwiecki ,  Matthias W. Rath ,  Anna Goc ,  Waldemar Sumera

IPC分类号： A61K31/07 ,  A61K31/375 ,  A61K31/355 ,  A61K31/198 ,  A61K31/385 ,  A61K31/047 ,  A61K31/01 ,  A61K36/28 ,  A61K36/15 ,  A61K36/87 ,  A61K36/45 ,  A61K33/30 ,  A61P27/02

CPC分类号： A61K31/07 ,  A23K20/174 ,  A23L33/105 ,  A61K8/27 ,  A61K31/01 ,  A61K31/047 ,  A61K31/198 ,  A61K31/355 ,  A61K31/375 ,  A61K31/385 ,  A61K33/30 ,  A61K36/15 ,  A61K36/28 ,  A61K36/45 ,  A61K36/87 ,  A61K36/88 ,  A61P27/02

摘要： The nutrient mixture made up of vitamin, carotenoid, micronutrient, essential trace element, and plant extract was much more effective in proactively protecting the corneal cells (human) and retinal pigment endothelial cells (rat) against damaging effects of H2O2 and glycosylated proteins (AGE-BSA) compared to its individual components. A mixture is made up of vitamin A, vitamin C, vitamin E, Lycopene, lutein, marigold flower extract, a saffron extract, pine bark extract, grape seed extract, bilberry extract, lipoic acid, L-Arginine and zinc.

公开(公告)号：US20160106777A1

公开(公告)日：2016-04-21

申请号：US14517887

申请日：2014-10-19

申请人： Matthias W. Rath ,  Aleksandra Niedzwiecki ,  Anna Goc

发明人： Matthias W. Rath ,  Aleksandra Niedzwiecki ,  Anna Goc

IPC分类号： A61K33/18 ,  A61K31/201 ,  A61K31/23 ,  A61K31/353 ,  A61K31/216 ,  A61K31/375 ,  A61K31/51 ,  A61K31/525 ,  A61K31/455 ,  A61K31/191 ,  A61K31/4415 ,  A61K31/4188 ,  A61K31/519 ,  A61K31/714 ,  A61K31/593

CPC分类号： A61K33/18 ,  A61K31/05 ,  A61K31/13 ,  A61K31/19 ,  A61K31/191 ,  A61K31/195 ,  A61K31/197 ,  A61K31/20 ,  A61K31/201 ,  A61K31/216 ,  A61K31/22 ,  A61K31/23 ,  A61K31/231 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/593 ,  A61K31/675 ,  A61K31/7048 ,  A61K31/714 ,  A61K31/737 ,  A61K36/03 ,  A61K36/185 ,  A61K36/35 ,  A61K36/53 ,  A61K36/73 ,  A61K36/87 ,  A61K45/06 ,  A61K2300/00 ,  Y02A50/401

摘要： A composition for treating Lyme disease caused by Borrelia Species, comprising a vitamin, a small fatty acid signaling molecule, an essential amino acid, a flavonoid, a plant extract and a mineral.

摘要翻译： 用于治疗由疏螺旋体种引起的莱姆病的组合物，其包含维生素，小脂肪酸信号分子，必需氨基酸，类黄酮，植物提取物和矿物质。

公开(公告)号：US20160339057A1

公开(公告)日：2016-11-24

申请号：US15229245

申请日：2016-08-05

申请人： MATTHIAS W. RATH ,  Aleksandra Niedzwiecki ,  Anna Goc

发明人： MATTHIAS W. RATH ,  Aleksandra Niedzwiecki ,  Anna Goc

IPC分类号： A61K33/18 ,  A61K31/231 ,  A61K31/375 ,  A61K31/216 ,  A61K31/352 ,  A61K36/87 ,  A61K31/593 ,  A61K31/22

CPC分类号： A61K33/18 ,  A61K31/05 ,  A61K31/13 ,  A61K31/19 ,  A61K31/191 ,  A61K31/195 ,  A61K31/197 ,  A61K31/20 ,  A61K31/201 ,  A61K31/216 ,  A61K31/22 ,  A61K31/23 ,  A61K31/231 ,  A61K31/343 ,  A61K31/352 ,  A61K31/353 ,  A61K31/375 ,  A61K31/4188 ,  A61K31/4415 ,  A61K31/455 ,  A61K31/51 ,  A61K31/519 ,  A61K31/525 ,  A61K31/593 ,  A61K31/675 ,  A61K31/7048 ,  A61K31/714 ,  A61K31/737 ,  A61K36/03 ,  A61K36/185 ,  A61K36/35 ,  A61K36/53 ,  A61K36/73 ,  A61K36/87 ,  A61K45/06 ,  A61K2300/00 ,  Y02A50/401

摘要： Lyme disease caused by B. burgdorferi and B. garinii has been traditionally treated with antibiotics. However, to eradicate all three morphological forms of Borrelia species such as spirochetes, rounded bodies and biofilm more effective and safe treatment plan is required. In the instant application, Vitamins and Phytobiologicals have been tested for as a short term and long term treatment in vitro and on biofilm. The combination of tested compounds in form of Mix AO seems to be very beneficial in treating Lyme disease caused by B. burgdorferi and B. garinii.

摘要翻译： 传统上使用抗生素治疗布氏疏螺旋体和布氏球菌引起的莱姆病。 然而，为了根除所有三种形态形态的螺旋体，圆形体和生物膜，需要更有效和安全的治疗方案。 在即时应用中，维生素和植物生物学已被测试为体外和生物膜的短期和长期治疗。 混合AO形式的测试化合物的组合似乎非常有益于治疗由布氏疏螺旋体和布氏梭菌引起的莱姆病。

公开(公告)号：US10716767B2

公开(公告)日：2020-07-21

申请号：US15866450

申请日：2018-01-09

申请人： Aleksandra Niedzwiecki ,  Matthias W Rath ,  Anna Goc ,  Waldemar Sumera

发明人： Aleksandra Niedzwiecki ,  Matthias W Rath ,  Anna Goc ,  Waldemar Sumera

IPC分类号： A61K31/07 ,  A61K31/375 ,  A61K31/355 ,  A61K31/198 ,  A61K31/385 ,  A61K31/047 ,  A61P27/02 ,  A61K36/28 ,  A61K36/15 ,  A61K36/87 ,  A61K36/45 ,  A61K33/30 ,  A61K31/01

摘要： The nutrient mixture made up of vitamin, carotenoid, micronutrient, essential trace element, and plant extract was much more effective in proactively protecting the corneal cells (human) and retinal pigment endothelial cells (rat) against damaging effects of H2O2 and glycosylated proteins (AGE-BSA) compared to its individual components. A mixture is made up of vitamin A, vitamin C, vitamin E, Lycopene, lutein, marigold flower extract, a saffron extract, pine bark extract, grape seed extract, bilberry extract, lipoic acid, L-Arginine and zinc.

公开(公告)号：US10238619B1

公开(公告)日：2019-03-26

申请号：US15799573

申请日：2017-10-31

申请人： Matthias W Rath ,  Aleksandra Niedzwiecki ,  Anna Goc

发明人： Matthias W Rath ,  Aleksandra Niedzwiecki ,  Anna Goc

IPC分类号： A61K31/20 ,  A61K31/122 ,  A61K31/11 ,  A61K31/05

摘要： A composition of a fatty acids, essential oils, plant extracts, phenols, and terpenoids and used for treating Lyme disease is disclosed. Compositions as a mix of ingredients was tested in various combinations and concentration against active (spirochetes), as well as persistent/latent forms, (knob-shaped/rounded-forms) and biofilm of the bacteria, i.e., Borrelia burgdorferi and Borrelia garinii. The results document pleiotropic effects of the tested combinations against all tested forms of Borrelia sp. and show their better efficacy than doxycycline—the current antibiotic treatment against Lyme disease.