公开(公告)号：US5874111A

公开(公告)日：1999-02-23

申请号：US779904

申请日：1997-01-07

申请人： Amarnath Maitra ,  Prashant Kumar Ghosh ,  Tapas K. De ,  Sanjeeb Kumar Sahoo

发明人： Amarnath Maitra ,  Prashant Kumar Ghosh ,  Tapas K. De ,  Sanjeeb Kumar Sahoo

IPC分类号： A61K47/30 ,  A61K9/51 ,  B01J13/04 ,  B01J13/18 ,  C08F2/32 ,  C08F2/44 ,  C08F6/16 ,  C08F26/10 ,  C08L39/06 ,  A61K47/32 ,  B01J13/20

CPC分类号： A61K9/5138 ,  A61K9/5146 ,  A61K9/5192 ,  B01J13/043 ,  B01J13/18

摘要： Preparation of highly monodispersed polymeric hydrophilic nanoparticles having a size of up to 100 nm (in which may have drug substances encapsulated therein. The process comprises subjecting a mixture of an aqueous solution of a monomer or preformed polymer reverse micelles, a cross linking agent, initiator, and optionally, a drug or target substance to polymerization. The polymerized reaction product is dried for removal of solvent to obtain dried nanoparticles and surfactant employed in the process of preparing reverse micelles. The dry mass is dispersed in aqueous buffer and the surfactant and other toxic material are removed therefrom.

摘要翻译： 制备尺寸高达100nm的高度单分散的聚合物亲水性纳米颗粒（其中可以包封药物物质），该方法包括使单体水溶液或预成型聚合物反胶束，交联剂，引发剂 和任选的药物或目标物质进行聚合，将聚合的反应产物干燥除去溶剂，得到干燥的纳米颗粒和制备反胶束的方法中使用的表面活性剂，将干质量分散在水性缓冲液和表面活性剂等中 从中除去有毒物质。

公开(公告)号：US06579519B2

公开(公告)日：2003-06-17

申请号：US09954722

申请日：2001-09-18

申请人： Amarnath Maitra ,  Ajay Kumar Gupta ,  Dipak Majumdar ,  Sumit Madan

发明人： Amarnath Maitra ,  Ajay Kumar Gupta ,  Dipak Majumdar ,  Sumit Madan

IPC分类号： A61K3174

CPC分类号： A61K9/5138 ,  A61K9/0048 ,  A61K9/1075 ,  A61K31/18 ,  A61K31/405 ,  A61K31/407 ,  A61K31/63 ,  A61K47/34

摘要： The present invention relates to sustained release and long residing opthalmic formulation having thermosensitivity, mucoadhesiveness, hydro gel properties and small particle size. The said formulation comprises micelle solution of random block co-polymer having a hydrophobic component and a hydrophillic component of general formula —(X+Y+Z-)m, and at least one hydrophobic drug with the block co-polymer solution. The invention also provides a process of preparing said formulation.

摘要翻译： 本发明涉及具有热敏性，粘膜粘附性，水凝胶性质和小粒径的持续释放和长期驻留的眼药物。 所述制剂包含具有疏水组分和通式 - （X + Y + Z-）m的亲水组分的无规嵌段共聚物的胶束溶液和至少一种具有嵌段共聚物溶液的疏水性药物。 本发明还提供了制备所述制剂的方法。

公开(公告)号：US06555376B2

公开(公告)日：2003-04-29

申请号：US10201247

申请日：2002-07-24

申请人： Amarnath Maitra ,  Subho Mozumdar ,  Susmita Mitra ,  Indrajit Roy

发明人： Amarnath Maitra ,  Subho Mozumdar ,  Susmita Mitra ,  Indrajit Roy

IPC分类号： C12N1588

CPC分类号： B82Y5/00 ,  A61K47/549 ,  A61K47/6923 ,  A61K47/6929 ,  C12N15/88

摘要： The present invention relates to a process of entrapping genetic materials in nanoparticles of inorganic metal salts of size below 100 nm diameter to form non-viral carriers for delivery of genes. The process comprises the steps of dissolving surfactants and a cosurfactant in oil to obtain reverse micelles. An aqueous solution of genetic material is added to the reverse micelles. Thereafter the reverse micelles are divided into two equal parts. To one part, aqueous solution of inorganic metal salts is dissolved to obtain optically clear and transparent reverse micelles. To the second part aqueous solution of precipitating agent is added to obtain optically clear and transparent reverse micelles. The two equally divided parts of reverse micelles are mixed to form inorganic nanopartcles encapsulating added genetic material. Thereafter, the nanoparticles are separated from reverse micelles, the inorganic nanoparticles are dispersed in water and dialyzed to remove free metal salts, surfactant and oil.

摘要翻译： 本发明涉及一种在大于100nm直径的无机金属盐的纳米颗粒中捕获遗传物质以形成用于递送基因的非病毒载体的方法。 该方法包括将表面活性剂和辅助表面活性剂溶解在油中以获得反胶束的步骤。 将遗传物质的水溶液加入到反胶束中。 此后将反胶束分成两等份。 一方面，将无机金属盐的水溶液溶解，得到透明透明的反胶束。 向第二部分添加沉淀剂水溶液以获得光学透明且透明的反胶束。 将两个等分的部分反胶束混合以形成包封添加的遗传物质的无机纳米颗粒。 此后，将纳米颗粒与反胶束分离，将无机纳米颗粒分散在水中并透析以除去游离金属盐，表面活性剂和油。

公开(公告)号：US06322817B1

公开(公告)日：2001-11-27

申请号：US09401927

申请日：1999-09-23

申请人： Amarnath Maitra ,  Sanjeeb Kumar Sahoo ,  Prasanta Kumar Ghosh ,  Anand C. Burman ,  Rama Mukherjee ,  Dhiraj Khattar ,  Mukesh Kumar ,  Soumendu Paul

发明人： Amarnath Maitra ,  Sanjeeb Kumar Sahoo ,  Prasanta Kumar Ghosh ,  Anand C. Burman ,  Rama Mukherjee ,  Dhiraj Khattar ,  Mukesh Kumar ,  Soumendu Paul

IPC分类号： A61K4730

CPC分类号： A61K9/5138 ,  A61K9/1075 ,  A61K9/5146 ,  A61K9/5192 ,  A61K31/337 ,  Y10S977/906

摘要： This invention relates to pharmaceutical formulations of paclitaxel, its derivatives or analogs entrapped into nanoparticles of co-polymeric micelles, a process for preparing the same and the use thereof.

摘要翻译： 本发明涉及包埋在共聚合胶束纳米颗粒中的紫杉醇，其衍生物或类似物的药物制剂，其制备方法及其用途。