公开(公告)号：US20120083505A1

公开(公告)日：2012-04-05

申请号：US13377554

申请日：2010-06-08

申请人： Klaus M Beier ,  Michael Dittgen ,  Eike Dittgen ,  Alfred Pauls

发明人： Klaus M Beier ,  Michael Dittgen ,  Eike Dittgen ,  Alfred Pauls

IPC分类号： A61K31/485 ,  A61P15/00

CPC分类号： A61K31/485

摘要： The present invention is directed to an opioid receptor antagonist or a pharmaceutically acceptable salt thereof for use in a method of acute treatment of paraphilic sexual arousal states in patients suffering from paraphilia.

摘要翻译： 本发明涉及一种阿片样物质受体拮抗剂或其药学上可接受的盐，用于急性治疗患有瘫痪症状的患者的性唤起状态的方法。

公开(公告)号：US5663203A

公开(公告)日：1997-09-02

申请号：US350171

申请日：1994-11-30

申请人： Roland Ekerdt ,  Georg Raptis ,  Alfred Pauls

发明人： Roland Ekerdt ,  Georg Raptis ,  Alfred Pauls

IPC分类号： A61K31/557

CPC分类号： A61K31/5585

摘要： The invention relates to a dermal application form of prostacyclin derivatives of Formula I ##STR1## wherein R.sub.1 means hydrogen or alkyl of 1-10 carbon atoms,A is a --CH.sub.2 --CH.sub.2 --, trans-CH.dbd.CH-- or --C.ident.C-group,W represents a hydroxymethyl group which is free or functionally modified at the hydroxy group, the OH-group being in the .alpha.- or .beta.-position,X is a CH.sub.2 -group or an oxygen atom,Z is hydrogen or a cyano group,D means a straight-chain or branched, saturated alkylene group of 1-5 carbon atoms,E is a --C.ident.C-linkage or a direct bond,R.sub.2 is a straight- or branched-chain, saturated alkyl group of 1-7 carbon atoms,R.sub.3 is a free or functionally modified hydroxy group,and, if R.sub.1 means a hydrogen atom, containing the salts thereof with physiologically compatible bases, for the treatment of ulcerations caused by arterial occlusive diseases, and other skin disorders.

摘要翻译： 本发明涉及式I的前列环素衍生物（I）的真皮施用形式，其中R 1表示氢或1-10个碳原子的烷基，A是-CH 2 -CH 2 - ，反式-CH = CH-或 - C = C - 基，W表示在羟基上游离或官能改性的羟甲基，OH-位于α位或β位，X为CH 2基或氧原子，Z为氢 或氰基，D表示1-5个碳原子的直链或支链饱和亚烷基，E是-C = C-键或直接键，R2是直链或支链饱和烷基 1-7个碳原子的基团，R3是游离或官能改性的羟基，并且如果R 1表示含有其与生理相容性碱的盐的氢原子，用于治疗由动脉闭塞性疾病引起的溃疡和其它皮肤 疾病