公开(公告)号：US07853406B2

公开(公告)日：2010-12-14

申请号：US10462108

申请日：2003-06-13

申请人： Seth Gary Michelson ,  Alex Lawrence Bangs

发明人： Seth Gary Michelson ,  Alex Lawrence Bangs

IPC分类号： G01N33/48

CPC分类号： G06F19/704 ,  G06F19/12

摘要： Methods and apparatus to identify a potential toxicity of a therapy in a biological system are described. In one embodiment, a method uses a computer model that represents a set of biological processes of the biological system. The method includes executing the computer model to identify a first set of biological processes contributing to the occurrence of a toxic state of the biological system. The method also includes identifying a set of biological assays based on the first set of biological processes and testing the therapy in the set of biological assays to identify a second set of biological processes modified by the therapy. The method further includes identifying the potential toxicity of the therapy based on the second set of biological processes.

摘要翻译： 描述了鉴定生物系统中治疗潜在毒性的方法和装置。 在一个实施例中，一种方法使用表示该生物系统的一组生物过程的计算机模型。 该方法包括执行计算机模型以识别有助于生物系统的毒性状态发生的第一组生物过程。 该方法还包括基于第一组生物过程识别一组生物测定，并测试该组生物测定中的治疗，以鉴定通过治疗修饰的第二组生物学过程。 该方法还包括基于第二组生物过程鉴定治疗的潜在毒性。

公开(公告)号：US20110275527A1

公开(公告)日：2011-11-10

申请号：US12968097

申请日：2010-12-14

申请人： Seth Gary Michelson ,  Alex Lawrence Bangs

发明人： Seth Gary Michelson ,  Alex Lawrence Bangs

IPC分类号： C40B30/04 ,  C12Q1/02

CPC分类号： G16C20/30 ,  G16B5/00

摘要： Methods and apparatus to identify a potential toxicity of a therapy in a biological system are described. In one embodiment, a method uses a computer model that represents a set of biological processes of the biological system. The method includes executing the computer model to identify a first set of biological processes contributing to the occurrence of a toxic state of the biological system. The method also includes identifying a set of biological assays based on the first set of biological processes and testing the therapy in the set of biological assays to identify a second set of biological processes modified by the therapy. The method further includes identifying the potential toxicity of the therapy based on the second set of biological processes.

摘要翻译： 描述了鉴定生物系统中治疗潜在毒性的方法和装置。 在一个实施例中，一种方法使用表示该生物系统的一组生物过程的计算机模型。 该方法包括执行计算机模型以识别有助于生物系统的毒性状态发生的第一组生物过程。 该方法还包括基于第一组生物过程识别一组生物测定，并测试该组生物测定中的治疗，以鉴定通过治疗修饰的第二组生物学过程。 该方法还包括基于第二组生物过程鉴定治疗的潜在毒性。