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公开(公告)号：US07842810B2
公开(公告)日：2010-11-30
申请号：US11393558
申请日：2006-03-30
申请人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Alejandro Santillan, Jr. , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Alejandro Santillan, Jr. , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号： C07D215/00
CPC分类号： A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译： 抗菌化合物，含有它们的组合物，以及用于抑制细菌活性和治疗，预防或抑制细菌感染的方法。
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公开(公告)号：US20100274005A1
公开(公告)日：2010-10-28
申请号：US12833752
申请日：2010-07-09
申请人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号： C07D487/04 , C07D471/04 , C07D417/14 , C07D403/14 , C07D498/04
CPC分类号： A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
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3.发明申请TETRAHYDROISOQUINOLINE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 审中-公开作为组胺H3受体的调节剂的四氢喹啉化合物公开(公告)号：US20090099158A1
公开(公告)日：2009-04-16
申请号：US12039162
申请日：2008-02-28
IPC分类号： A61K31/4725 , C07D401/02 , A61K31/551 , A61K31/496 , A61P25/00 , C07D471/04 , A61K31/4985 , A61K31/5377 , C07D413/02
CPC分类号： C07D401/06 , C07D217/02 , C07D217/06 , C07D405/06 , C07D409/06 , C07D471/04 , C07D487/04 , C07D487/08
摘要： Certain substituted tetrahydroisoquinoline compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的四氢异喹啉化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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公开(公告)号：US08232391B2
公开(公告)日：2012-07-31
申请号：US12833682
申请日：2010-07-09
申请人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号： C07D279/10 , A61K31/54
CPC分类号： A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
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5.发明申请INDOLE AND BENZOTHIOPHENE COMPOUNDS AS MODULATORS OF THE HISTAMINE H3 RECEPTOR 审中-公开作为组胺H3受体的调节剂的吲哚和苯并噻唑化合物公开(公告)号：US20110178062A1
公开(公告)日：2011-07-21
申请号：US12039143
申请日：2008-02-28
IPC分类号： A61K31/553 , C07D401/14 , A61K31/551 , A61K31/4545 , A61K31/496 , C07D403/14 , A61K31/454 , A61K31/55 , C07D413/14 , C07D417/14 , A61K31/541 , A61P25/00
CPC分类号： C07D403/06 , C07D209/14 , C07D401/06 , C07D401/12
摘要： Certain substituted indole and benzothiophene compounds are histamine H3 receptor modulators useful in the treatment of histamine H3 receptor-mediated diseases.
摘要翻译： 某些取代的吲哚和苯并噻吩化合物是可用于治疗组胺H3受体介导的疾病的组胺H3受体调节剂。
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公开(公告)号：US20100280240A1
公开(公告)日：2010-11-04
申请号：US12833621
申请日：2010-07-09
申请人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brain J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J.M. Wiener
发明人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brain J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J.M. Wiener
IPC分类号： C07D487/04 , C07D471/04 , C07D417/14 , C07D403/14 , C07D498/04
CPC分类号： A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译： 抗菌化合物，含有它们的组合物，以及用于抑制细菌活性和治疗，预防或抑制细菌感染的方法。
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公开(公告)号：US08242275B2
公开(公告)日：2012-08-14
申请号：US12833621
申请日：2010-07-09
申请人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
发明人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, Jr. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J. M. Wiener
IPC分类号： C07D471/02
CPC分类号： A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译： 抗菌化合物，含有它们的组合物，以及用于抑制细菌活性和治疗，预防或抑制细菌感染的方法。
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公开(公告)号：US20100274004A1
公开(公告)日：2010-10-28
申请号：US12833682
申请日：2010-07-09
申请人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J.M. Wiener
发明人： Brett D. Allison , Laurent Gomez , Cheryl A. Grice , Michael D. Hack , Brian J. Morrow , S. Timothy Motley , Alejandro Santillan, JR. , Karen J. Shaw , Kimberly L. Schwarz , Liu Y. Tang , Hariharan Venkatesan , John J.M. Wiener
IPC分类号： C07D487/04 , C07D471/04 , C07D417/14 , C07D403/14 , C07D498/04
CPC分类号： A61K31/4375 , A61K31/444 , A61K31/4453 , A61K31/4709 , A61K31/498 , A61K31/538 , A61K31/5383 , A61K31/5415 , A61K31/55 , C07D401/04 , C07D401/14 , C07D405/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： Antibacterial compounds, compositions containing them, and methods of use for the inhibition of bacterial activity and the treatment, prevention or inhibition of bacterial infection.
摘要翻译： 抗菌化合物，含有它们的组合物，以及用于抑制细菌活性和治疗，预防或抑制细菌感染的方法。
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9.发明申请Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase 有权噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯胺作为白三烯A4水解酶的调节剂公开(公告)号：US20090258854A1
公开(公告)日：2009-10-15
申请号：US12421406
申请日：2009-04-09
申请人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
发明人： Genesis M. Bacani , Diego Broggini , Eugene Y. Cheung , Christa C. Chrovian , Xiaohu Deng , Anne M. Fourie , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearny , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Jimmy T. Liang , Susanne Lochner , Neelakandha S. Mani , Alejandro Santillan, JR. , Kathleen Sappey , Kia Sepassi , Virginia M. Tanis , Alvah T. Wickboldt , John J. M. Wiener , Hartmut Zinser
IPC分类号： A61K31/437 , C07D513/04 , A61K31/506 , A61K31/5377 , A61K31/4985 , A61P29/00 , C12N9/50 , C07D453/02
CPC分类号： C07D498/04 , C07D451/02
摘要： Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amine compounds are described, which are useful as LTA4 hydrolase (LTA4H) modulators. Such compounds may be used in pharmaceutical compositions and methods for modulation of LTA4H and for the treatment of disease states, disorders, and conditions mediated by LTA4 hydrolase activity.
摘要翻译： 描述了噻唑并吡啶-2-基氧基 - 苯基和噻唑并吡嗪-2-基氧基 - 苯基胺化合物，其可用作LTA4水解酶（LTA4H）调节剂。 这样的化合物可以用于调节LTA4H的药物组合物和方法以及用于治疗由LTA4水解酶活性介导的疾病状态，障碍和病症。
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10.发明申请Aryl-substituted bridged or fused diamines as modulators of leukotriene A4 hydrolase 有权芳基取代的桥连或稠合二胺作为白三烯A4水解酶的调节剂公开(公告)号：US20090111794A1
公开(公告)日：2009-04-30
申请号：US12291018
申请日：2008-10-30
申请人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillan, JR.
发明人： Genesis M. Bacani , Scott D. Bembenek , Wendy Eccles , James P. Edwards , Matthew T. Epperson , Laurent Gomez , Cheryl A. Grice , Aaron M. Kearney , Adrienne M. Landry-Bayle , Alice Lee-Dutra , Kelly J. McClure , Taraneh Mirzadegan , Alejandro Santillan, JR.
IPC分类号： A61K31/55 , C07D277/68 , C07D263/54 , C07D487/08 , A61K31/423 , A61K31/4439 , A61P37/02 , A61K31/497 , A61K31/428 , C07D401/14 , C07D417/14
CPC分类号： C07D487/08 , C07D417/12 , C07D451/04 , C07D471/04 , C07D471/08 , C07D487/04
摘要： Aryl-substituted bridged or fused diamine compounds, pharmaceutical compositions containing them, and methods of using the compounds and the pharmaceutical compositions for leukotriene A4 hydrolase (LTA4H or LTA4H) modulation and for the treatment of disease states, disorders, and conditions mediated by LTA4H activity, such as allergy, asthma, autoimmune diseases, pruritis, inflammatory bowel disease, ulcerative colitis, and cardiovascular disease, including atherosclerosis and prevention of myocardial infarction.
摘要翻译： 芳基取代的桥连或稠合二胺化合物，含有它们的药物组合物，以及使用该化合物和药物组合物用于白三烯A4水解酶（LTA4H或LTA4H）调节和治疗由LTA4H活性介导的疾病状态，障碍和病症的方法 ，例如过敏，哮喘，自身免疫性疾病，瘙痒炎，炎性肠病，溃疡性结肠炎和心血管疾病，包括动脉粥样硬化和预防心肌梗死。
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