Glycidic acid ester and process of preparation
    9.
    发明授权
    Glycidic acid ester and process of preparation 失效
    糖苷酸酯及其制备方法

    公开(公告)号:US5008411A

    公开(公告)日:1991-04-16

    申请号:US416295

    申请日:1989-10-02

    摘要: A process for the preparing a compound of the formula ##STR1## wherein R.sub.1 and R.sub.2 are each independently hydrogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl or nitro; or R.sub.1 and R.sub.2 taken together with the benzene ring to which they are attached are naphthalene, and Ar is p-lower alkoxy phenyl.which comprises reacting ##STR2## wherein R.sub.1 and R.sub.2 are as described above with the compound of the formula ##STR3## wherein Ar is as described above, in an aromatic organic compound. The intermediates formed by the process of the invention are useful in the production of thiazepin-4(5H)-ones which have activity as calcium channel blockers and accordingly are useful as agents for lowering blood pressure and agents for treating ischemia.

    摘要翻译: 制备式IV化合物的方法,其中R 1和R 2各自独立地为氢,1至4个碳原子的烷基,1至4个碳原子的烷氧基,卤素,三氟甲基或硝基; 或者R 1和R 2与它们所连接的苯环一起为萘,Ar为对低级烷氧基苯基。 其中包括使其中R 1和R 2如上所述的其中Ar如上所述的式IIIa化合物在芳族有机化合物中反应。 通过本发明的方法形成的中间体可用于制备具有钙通道阻断剂活性的硫氮平-4(5H)酮,因此可用作降低血压的药剂和用于治疗缺血的药剂。

    Cryogenic surgical tool
    10.
    发明授权
    Cryogenic surgical tool 失效
    低温手术工具

    公开(公告)号:US4770171A

    公开(公告)日:1988-09-13

    申请号:US13949

    申请日:1987-02-12

    IPC分类号: A61B18/00 A61B18/02 A61B17/36

    CPC分类号: A61B18/02 A61B2018/00101

    摘要: A cryogenic surgical tool (10) is provided to contact and freeze predetermined areas of tissue. The cryogenic surgical tool (10) consists of a low thermal conductivity handle (12) which is threadedly secured to an applicator member (20). The applicator member (20) includes an internal bore (26) within which is fitted an absorbent member (34) which absorbs a cryogenic liquid. The applicator member (20) includes an applicator first end surface (24) which contacts tissue and draws heat therefrom to extremely low temperatures, thus generally destroying the tissue contacted. The applicator member (20) includes a plurality of housing sidewall through openings (32) which are vent holes and allow for vaporization of the cryogenic liquid from the absorbent member (34) and prevents undue pressures from building up a cavity formed by bore (26) within housing member (20).

    摘要翻译: 提供一种低温外科手术工具(10)来接触和冻结组织的预定区域。 低温外科手术工具(10)由低导热性手柄(12)组成,该手柄螺纹地固定到涂抹器构件(20)上。 涂抹器构件(20)包括内孔(26),其内装有吸收低温液体的吸收构件(34)。 涂抹器构件(20)包括施加器第一端表面(24),其接触组织并将热量从其中吸取到极低温度,从而通常破坏接触的组织。 施用器构件(20)包括多个壳体侧壁通孔(32),其是通气孔并允许来自吸收构件(34)的低温液体蒸发,并且防止不必要的压力建立由孔(26)形成的空腔 )在壳体构件(20)内。