公开(公告)号：US07531554B2

公开(公告)日：2009-05-12

申请号：US11133470

申请日：2005-05-20

申请人： Motohide Satoh ,  Takashi Matsuda ,  Satoshi Okuda ,  Hiroshi Kawakami ,  Hisateru Aramaki ,  Hisashi Shinkai ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki ,  Mitsuru Takahashi ,  Naohito Yamada ,  Akemi Nagao

发明人： Motohide Satoh ,  Takashi Matsuda ,  Satoshi Okuda ,  Hiroshi Kawakami ,  Hisateru Aramaki ,  Hisashi Shinkai ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki ,  Mitsuru Takahashi ,  Naohito Yamada ,  Akemi Nagao

IPC分类号： C07D215/04 ,  A61K31/44

CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D401/06 ,  C07D405/06 ,  C07D491/04

摘要： Provision of a compound having an anti-HIV activity, particularly an integrase inhibitory activity.A 4-oxoquinoline compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification. The present invention also relates to a pharmaceutical composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; an integrase inhibitor, an antiviral agent, anti-HIV agent, and the like, which contains the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient; an anti-HIV composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and one or more other kinds of anti-HIV activity substances as active ingredients; an anti-HIV agent containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient, which is used for a multiple drug therapy with other anti-HIV agent(s), and the like.

摘要翻译： 提供具有抗HIV活性的化合物，特别是整合酶抑制活性。 由下式[I]表示的4-氧代喹啉化合物或其药学上可接受的盐：其中每个符号如说明书中所定义。 本发明还涉及含有4-氧代喹啉化合物或其药学上可接受的盐和药学上可接受的载体的药物组合物; 含有4-氧代喹啉化合物或其药学上可接受的盐作为活性成分的整合酶抑制剂，抗病毒剂，抗HIV剂等; 含有4-氧代喹啉化合物或其药学上可接受的盐的抗HIV组合物和一种或多种其它类型的抗HIV活性物质作为活性成分; 含有4-氧代喹啉化合物或其药学上可接受的盐作为活性成分的抗HIV剂，其用于与其它抗HIV剂的多重药物治疗等。

公开(公告)号：US20060019906A1

公开(公告)日：2006-01-26

申请号：US11133470

申请日：2005-05-20

申请人： Motohide Satoh ,  Takashi Matsuda ,  Satoshi Okuda ,  Hiroshi Kawakami ,  Hisateru Aramaki ,  Hisashi Shinkai ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki ,  Mitsuru Takahashi ,  Naohito Yamada ,  Akemi Nagao

发明人： Motohide Satoh ,  Takashi Matsuda ,  Satoshi Okuda ,  Hiroshi Kawakami ,  Hisateru Aramaki ,  Hisashi Shinkai ,  Yuji Matsuzaki ,  Wataru Watanabe ,  Kazunobu Yamataka ,  Shinichi Kiyonari ,  Shuichi Wamaki ,  Mitsuru Takahashi ,  Naohito Yamada ,  Akemi Nagao

IPC分类号： A61K31/4704 ,  C07H17/02 ,  C07D215/36

CPC分类号： C07D215/56 ,  C07D401/04 ,  C07D401/06 ,  C07D405/06 ,  C07D491/04

摘要： Provision of a compound having an anti-HIV activity, particularly an integrase inhibitory activity. A 4-oxoquinoline compound represented by the following formula [I] or a pharmaceutically acceptable salt thereof: wherein each symbol is as defined in the specification. The present invention also relates to a pharmaceutical composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier; an integrase inhibitor, an antiviral agent, anti-HIV agent, and the like, which contains the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient; an anti-HIV composition containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof, and one or more other kinds of anti-HIV activity substances as active ingredients; an anti-HIV agent containing the 4-oxoquinoline compound or a pharmaceutically acceptable salt thereof as an active ingredient, which is used for a multiple drug therapy with other anti-HIV agent(s), and the like.

摘要翻译： 提供具有抗HIV活性的化合物，特别是整合酶抑制活性。 由下式[I]表示的4-氧代喹啉化合物或其药学上可接受的盐：其中每个符号如说明书中所定义。 本发明还涉及含有4-氧代喹啉化合物或其药学上可接受的盐和药学上可接受的载体的药物组合物; 含有4-氧代喹啉化合物或其药学上可接受的盐作为活性成分的整合酶抑制剂，抗病毒剂，抗HIV剂等; 含有4-氧代喹啉化合物或其药学上可接受的盐的抗HIV组合物和一种或多种其它类型的抗HIV活性物质作为活性成分; 含有4-氧代喹啉化合物或其药学上可接受的盐作为活性成分的抗HIV剂，其用于与其它抗HIV剂的多重药物治疗等。