公开(公告)号：US07674824B2

公开(公告)日：2010-03-09

申请号：US11515553

申请日：2006-09-05

申请人： Satish Chandra Upadhyay ,  Manoj Kumar Pananchukunnath ,  Ajeet Kumar Singh ,  Deepti Jain ,  Deepak Judgelal Parshotamdas ,  Rama Mukharjee ,  Anand C Burman

发明人： Satish Chandra Upadhyay ,  Manoj Kumar Pananchukunnath ,  Ajeet Kumar Singh ,  Deepti Jain ,  Deepak Judgelal Parshotamdas ,  Rama Mukharjee ,  Anand C Burman

IPC分类号： A61K31/282

CPC分类号： A61K47/26 ,  A61K9/0019 ,  A61K31/282 ,  A61K31/70 ,  A61K31/7012

摘要： A storage stable pharmaceutical composition comprising a solution of Oxaliplatin in water and a catalytic amount of a carbohydrate. A process for forming such pharmaceutical composition comprising dissolving a known amount of Oxaliplatin in water; adding an amount of carbohydrate in the range of 0.0010% to 0.05% w/v with respect to such solution; agitating the mixture to get clear solution; filtering it through a filter membrane under aseptic conditions; and filling the solution resulting into glass vials sealed with elastomeric stoppers and aluminium flip-off seals.

摘要翻译： 一种储存稳定的药物组合物，其包含奥沙利铂在水中的溶液和催化量的碳水化合物。 一种形成这种药物组合物的方法，包括将已知量的奥沙利铂溶于水中; 相对于这种溶液加入0.001-0.05％w / v范围内的碳水化合物量; 搅拌混合物以得到澄清溶液; 在无菌条件下通过滤膜过滤; 并将溶液填充到用弹性塞子和铝翻盖密封件密封的玻璃小瓶中。