公开(公告)号：US4322423A

公开(公告)日：1982-03-30

申请号：US134441

申请日：1980-03-27

Applicant: Claus Schneider ,  Karl-Heinz Weber ,  Adolf Langbein ,  Wolf D. Bechtel ,  Karin Boke

Inventor： Claus Schneider ,  Karl-Heinz Weber ,  Adolf Langbein ,  Wolf D. Bechtel ,  Karin Boke

IPC: A61K31/435 ,  A61K31/4365 ,  A61P25/24 ,  A61P25/26 ,  C07D333/30 ,  C07D495/04 ,  A61K31/44 ,  C07D495/14

CPC classification number: C07D495/04 ,  C07D333/30

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is chlorine, bromine or alkyl of 1 to 3 carbon atoms;R.sub.2 is hydrogen or, when R.sub.1 is alkyl, chlorine or bromine;R.sub.1 and R.sub.2, together with each other, are straight alkylene of 3 to 4 carbon atoms;R.sub.3 is hydrogen, fluorine, chlorine, bromine, alkyl of 1 to 2 carbon atoms; hydroxyl or trifluoromethyl; andR.sub.4 is hydrogen, straight or branched alkyl of 1 to 4 carbon atoms or phenyl lower alkyl;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.

Abstract translation: 其中R 1是氯，溴或1至3个碳原子的烷基; R2是氢或当R1是烷基时，是氯或溴; R 1和R 2彼此一起是3至4个碳原子的直链亚烷基; R3是氢，氟，氯，溴，1至2个碳原子的烷基; 羟基或三氟甲基; R4为氢，1〜4个碳原子的直链或支链烷基或苯基低级烷基; 和无毒的，药学上可接受的酸加成盐。 化合物及其盐可用作抗抑郁药。

公开(公告)号：US4087531A

公开(公告)日：1978-05-02

申请号：US730123

申请日：1976-10-06

Applicant: Adolf Langbein ,  Gerhard Walther ,  Peter Danneberg ,  Franz Josef Kuhn

Inventor： Adolf Langbein ,  Gerhard Walther ,  Peter Danneberg ,  Franz Josef Kuhn

IPC: C07D211/58 ,  C07D401/04 ,  A61K31/445

CPC classification number: C07D211/58

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, acetyl, alkyl of 1 to 3 carbon atoms or phenyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as CNS-depressants, sedatives and tranquilizers.

Abstract translation: 其中R1是氢，乙酰基，1至3个碳原子的烷基或苯基的式“IMAGE”化合物及其无毒的药学上可接受的酸加成盐; 化合物及其盐可用作CNS抑制剂，镇静剂和镇定剂。

公开(公告)号：US4038397A

公开(公告)日：1977-07-26

申请号：US699985

申请日：1976-06-25

Applicant: Herbert Merz ,  Adolf Langbein ,  Gerard Walther ,  Klaus Stockhaus

Inventor： Herbert Merz ,  Adolf Langbein ,  Gerard Walther ,  Klaus Stockhaus

IPC: A61K31/395

CPC classification number: A61K31/395

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl, R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl,R.sub.4 is ##STR2## R.sub.5 is hydrogen, methyl or acetyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics.

公开(公告)号：US4004010A

公开(公告)日：1977-01-18

申请号：US627286

申请日：1975-10-30

Applicant: Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

Inventor： Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

IPC: A61K31/485 ,  C07D489/02 ,  C07D489/12

CPC classification number: A61K31/485 ,  C07D489/02 ,  C07D489/12

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 is methyl, phenyl or hydrogen,Z is --CH=CH-- or --CH.sub.2 --CH.sub.2 --, andR.sub.3 is hydrogen or methyl,And non-toxic, pharmacologically acceptable acid addition salts thereof; and a method using the same as analgesics and antitussives.

Abstract translation: 其中R为氢，甲基或乙酰基，R1为甲基，苯基或氢，Z为-CH = CH-或-CH2-CH2-，R3为氢原子的药物组合物为式 或甲基，和非毒性，药理学上可接受的酸添加量; 和使用其作为分析和反义词的方法。

公开(公告)号：US3998960A

公开(公告)日：1976-12-21

申请号：US627207

申请日：1975-10-30

Applicant: Herbert Merz ,  Adolf Langbein ,  Klaus Stockhaus ,  Helmut Wick

Inventor： Herbert Merz ,  Adolf Langbein ,  Klaus Stockhaus ,  Helmut Wick

IPC: A61K31/395 ,  A61K31/38 ,  A61K31/34

CPC classification number: A61K31/395

Abstract: Pharmaceutical compositions containing as an active ingredient a compound of the formula ##STR1## wherein R is hydrogen, methyl or acetyl,R.sub.1 and R.sub.2, which may be identical to or different from each other, are each alkyl of 1 to 3 carbon atoms,R.sub.3 is hydrogen or methyl, andY is oxygen or sulfur,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as analgesics, antitussives and opiate-antagonists.

Abstract translation: 其中R为氢，甲基或乙酰基，R 1和R 2可以相同或不同，含有1-3个碳原子的烷基，R3， 是氢或甲基，Y是氧或硫，或非毒性，药理学上可接受的酸加法盐; 以及使用该方法作为分析，抗原和反义寡核苷酸的方法。

公开(公告)号：US4333944A

公开(公告)日：1982-06-08

申请号：US233294

申请日：1981-02-10

Applicant: Karl-Heinz Weber ,  Adolf Langbein ,  Erich Lehr ,  Karin Boke ,  Franz J. Kuhn

Inventor： Karl-Heinz Weber ,  Adolf Langbein ,  Erich Lehr ,  Karin Boke ,  Franz J. Kuhn

IPC: A61K31/55 ,  A61K31/551 ,  A61K31/5517 ,  A61P25/08 ,  A61P25/20 ,  A61P25/24 ,  A61P25/26 ,  C07D243/00 ,  C07D333/00 ,  C07D495/14

CPC classification number: C07D495/14

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is chlorine, bromine or iodine,R.sub.2 is hydrogen or halogen, andR.sub.3 is hydrogen, lower alkyl or hydroxy-lower alkyl, or when R.sub.3 is hydrogen, an alkali metal salt thereof; the compounds and their salts are useful as anxiolytics, anticonvulsives and sedatives.

Abstract translation: 其中R 1是氯，溴或碘，R 2是氢或卤素，R 3是氢，低级烷基或羟基 - 低级烷基，或者当R 3是氢时，其碱金属盐; 化合物及其盐可用作抗焦虑剂，抗惊厥药和镇静剂。

公开(公告)号：US4100288A

公开(公告)日：1978-07-11

申请号：US714045

申请日：1976-08-13

Applicant: Herbert Merz ,  Gerhard Walther ,  Adolf Langbein ,  Klaus Stockhaus ,  Helmut Wick

Inventor： Herbert Merz ,  Gerhard Walther ,  Adolf Langbein ,  Klaus Stockhaus ,  Helmut Wick

IPC: C07D489/02 ,  A61K31/47 ,  A61K31/485 ,  A61P25/04 ,  A61P25/30 ,  C07D489/08

CPC classification number: C07D489/08

Abstract: Diastereoisomers of the compound of the formula ##STR1## and non-toxic, pharmacologically acceptable acid addition salts thereof; the isomers as well as their salts are useful as analgesics and morphine-antagonists.

Abstract translation: 式“化合物”的非对映异构体及其无毒的药学上可接受的酸加成盐; 异构体及其盐可用作镇痛药和吗啡拮抗剂。

公开(公告)号：US4087532A

公开(公告)日：1978-05-02

申请号：US673116

申请日：1976-04-02

Applicant: Herbert Merz ,  Adolf Langbein ,  Gerhard Walther ,  Klaus Stockhaus

Inventor： Herbert Merz ,  Adolf Langbein ,  Gerhard Walther ,  Klaus Stockhaus

IPC: C07D221/26 ,  A61K31/445

CPC classification number: C07D221/26

Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is methyl, ethyl or propyl,R.sub.2 is hydrogen, methyl or ethyl,R.sub.3 is hydrogen or methyl, andR.sub.4 is hydrogen, alkyl of 1 to 4 carbon atoms or alkanoyl of 2 to 5 carbon atoms,And non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as the salts are useful as analgesics.

Abstract translation: 其中R 1是甲基，乙基或丙基，R 2是氢，甲基或乙基，R 3是氢或甲基，R 4是氢，1至4个碳原子的烷基或2至5个碳原子的烷酰基， 和非毒性，药理学上可接受的酸添加量; 该化合物作为盐作为有用的方法。

公开(公告)号：US4473573A

公开(公告)日：1984-09-25

申请号：US495513

申请日：1983-05-17

Applicant: Herbert Merz ,  Adolf Langbein ,  Klaus Stockhaus

Inventor： Herbert Merz ,  Adolf Langbein ,  Klaus Stockhaus

IPC: C07D489/02 ,  A61K31/485 ,  A61P25/04 ,  C07D489/08

CPC classification number: C07D489/08

Abstract: The invention relates to N-(2-methoxyethyl)-noroxymorphone and pharmacologically acceptable acid addition salts thereof. These compounds are analgesically effective and can be used for controlling pain.

Abstract translation: 本发明涉及N-（2-甲氧基乙基） - 去氧吗啡酮及其药理学上可接受的酸加成盐。 这些化合物具有止痛效果，可用于控制疼痛。

公开(公告)号：US4069328A

公开(公告)日：1978-01-17

申请号：US732708

申请日：1976-10-15

Applicant: Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

Inventor： Adolf Langbein ,  Herbert Merz ,  Gerhard Walther ,  Klaus Stockhaus

IPC: A61K31/33 ,  C07D405/06 ,  A61K31/445 ,  A61K31/455

CPC classification number: C07D405/06 ,  A61K31/33

Abstract: Pharmaceutical compositions containing as an active ingredient compounds of the formula ##STR1## wherein R is hydrogen or methyl, or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as morphine-antagonists and analgesics.

Abstract translation: 药物组合物，其含有下式的化合物，其中R为氢或甲基，或其无毒的药理学上可接受的酸加成盐; 以及使用吗啡拮抗剂和镇痛药的方法。