公开(公告)号：US20230159451A1

公开(公告)日：2023-05-25

申请号：US17806371

申请日：2022-06-10

Applicant: Ascletis BioScience Co., Ltd.

Inventor： Bailing YANG ,  Bin LIANG ,  Yang LAI ,  Jinzi J. WU

IPC: C07D207/27 ,  C07D403/14 ,  C07D417/14 ,  C07D487/08 ,  C07D493/08 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  A61P31/14

CPC classification number: C07D207/27 ,  C07D403/14 ,  C07D417/14 ,  C07D487/08 ,  C07D493/08 ,  C07D405/14 ,  C07D409/14 ,  C07D471/04 ,  A61P31/14

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

公开(公告)号：US11541071B1

公开(公告)日：2023-01-03

申请号：US17664304

申请日：2022-05-20

Applicant: Ascletis BioScience Co., Ltd.

Inventor： Bin Liang ,  Bailing Yang ,  Yang Lai ,  Jinzi Jason Wu

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7084 ,  C07H21/02 ,  A61P35/00 ,  A61P31/12 ,  A61K45/06

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

公开(公告)号：US20240182448A1

公开(公告)日：2024-06-06

申请号：US18325502

申请日：2023-05-30

Applicant: Ascletis BioScience Co., Ltd.

Inventor： Jinzi Jason WU

IPC: C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14 ,  C07B2200/05

Abstract: Certain antiviral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

公开(公告)号：US20210038681A1

公开(公告)日：2021-02-11

申请号：US16965667

申请日：2018-02-09

Applicant: ASCLETIS BIOSCIENCE CO., LTD.

Inventor： Jinzi Jason Wu ,  Kristjan Gudmundsson ,  Bailing Yang ,  Bo Shan

IPC: A61K38/12 ,  A61P31/14

Abstract: The present invention provides a pharmaceutical composition for treating viral hepatitis C, comprising ravidasvir (ASC16) or a pharmaceutically acceptable salt thereof and danoprevir (ASC08) or a pharmaceutically acceptable salt thereof. The combined use of ASC16 and ASC08 has an enhanced effect, and the experimental results show that ASC16 and ASC08 can form an effective combined anti-HCV treatment regimen. Moreover, the administration regimen of ASC16 in combination of ASC08 further expands the action spectrum of therapeutic drugs. More importantly, the combined use of ASC16 and ASC08 solves the problem of drug resistance.

公开(公告)号：US12187704B2

公开(公告)日：2025-01-07

申请号：US18325502

申请日：2023-05-30

Applicant: Ascletis BioScience Co., Ltd.

Inventor： Jinzi Jason Wu

IPC: C07D401/14 ,  C07D403/14

Abstract: Certain antiviral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

公开(公告)号：US20240189337A1

公开(公告)日：2024-06-13

申请号：US18519961

申请日：2023-11-27

Applicant: ASCLETIS BIOSCIENCE CO., LTD.

Inventor： Bin LIANG ,  Bailing YANG ,  Yang LAI ,  Jinzi Jason WU

IPC: A61K31/7084 ,  A61K45/06 ,  A61P31/12 ,  A61P35/00 ,  C07H21/02

CPC classification number: A61K31/7084 ,  A61K45/06 ,  A61P31/12 ,  A61P35/00 ,  C07H21/02

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

公开(公告)号：US20240025885A1

公开(公告)日：2024-01-25

申请号：US18067147

申请日：2022-12-16

Applicant: Ascletis BioScience Co., Ltd

Inventor： Jinzi Jason WU

IPC: C07D403/14 ,  A61P31/14 ,  C07D417/14 ,  C07D413/14

CPC classification number: C07D403/14 ,  A61P31/14 ,  C07D417/14 ,  C07D413/14 ,  C07B2200/05

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

公开(公告)号：US11702406B1

公开(公告)日：2023-07-18

申请号：US18064419

申请日：2022-12-12

Applicant: Ascletis BioScience Co., Ltd.

Inventor： Jinzi J. Wu

IPC: C07D401/14 ,  C07D403/14

CPC classification number: C07D401/14 ,  C07D403/14 ,  C07B2200/05

Abstract: Certain antiviral compounds, pharmaceutical compositions, and methods related thereto are disclosed.

公开(公告)号：US20240270756A1

公开(公告)日：2024-08-15

申请号：US18416152

申请日：2024-01-18

Applicant: Ascletis BioScience Co., Ltd.

Inventor： Jinzi Jason WU ,  Bin LIANG

IPC: C07D498/14 ,  A61K31/4985 ,  A61K31/5383

CPC classification number: C07D498/14 ,  A61K31/4985 ,  A61K31/5383

Abstract: Disclosed are a compound of Formula I, stereoisomers, pharmaceutically acceptable salts and deuterated compounds thereof and a method for treating, inhibiting and/or preventing a disease or disorder in a subject in need thereof:




wherein A, R, G, Y and n are defined as in the present disclosure.

公开(公告)号：US11865132B2

公开(公告)日：2024-01-09

申请号：US18046339

申请日：2022-10-13

Applicant: Ascletis BioScience Co., Ltd.

Inventor： Bin Liang ,  Bailing Yang ,  Yang Lai ,  Jinzi Jason Wu

IPC: A01N43/04 ,  A61K31/70 ,  A61K31/7084 ,  C07H21/02 ,  A61P35/00 ,  A61P31/12 ,  A61K45/06

CPC classification number: A61K31/7084 ,  A61K45/06 ,  A61P31/12 ,  A61P35/00 ,  C07H21/02

Abstract: Certain anti-viral compounds, pharmaceutical compositions, and methods related thereto are disclosed.