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公开(公告)号：US12076581B2
公开(公告)日：2024-09-03
申请号：US18094419
申请日：2023-01-09
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Itzhak Kelson , Yona Keisari , Amnon Gat , Robert Den , Ofer Magen , Vered Domankevich , Lior Arazi , Tomer Cooks , Guy Heger , Mirta Duman{hacek over (c)}ić , Ishai Luz , Maayan Hedva Vatarescu
IPC: A61N5/10
CPC classification number: A61N5/1007 , A61N5/1031 , A61N5/1071
Abstract: A method for treating a tumor, comprising identifying a tumor as a glioblastoma tumor and implanting in the tumor identified as a glioblastoma tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 6.5 Mega becquerel (MBq) hour and 14.3 MBq hour, per centimeter length.
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公开(公告)号：US20240285971A1
公开(公告)日：2024-08-29
申请号：US18569636
申请日：2022-06-19
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Yona Keisari , Itzhak Kelson , Vered Domankevich , Yossi Nishri , Tomer Cooks , Margalit Efrati , Ronen Segal , Robert Den , Ishai Luz , Maayan Hedva Vatarescu , Sara Del Mare Roumani , Amit Shai
CPC classification number: A61N5/1001 , A61K9/0019 , A61K31/4412 , A61K51/1282 , C07K16/22 , A61K2039/505 , A61K2039/545 , A61N2005/101 , A61N2005/1024
Abstract: A vascular inhibitor for use as a medicament for treatment of a tumor of a patient wherein the administration pattern of the medicament comprises administering a therapeutically effective amount of the vascular inhibitor to the patient, in one or more sessions, and implanting seeds (204) carrying radium-224 in the tumor for intra-tumoral alpha-emitter radiotherapy less than two weeks from administering the vascular inhibitor.
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公开(公告)号：US20240285820A1
公开(公告)日：2024-08-29
申请号：US18569650
申请日：2022-06-19
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Yona Keisari , Itzhak Kelson , Vered Domankevich , Sara Del Mare Roumani , Robert Den , Fairuz Mansour , Ronen Segal , Margalit Efrati , Amit Shai , Yossi Nishri
IPC: A61K51/12 , A61K9/00 , A61K31/4245 , A61K31/437 , A61K31/454 , A61K31/4985 , A61K31/635 , A61K39/00 , A61K39/395 , A61P35/00
CPC classification number: A61K51/1282 , A61K9/0024 , A61K31/4245 , A61K31/437 , A61K31/454 , A61K31/4985 , A61K31/635 , A61K39/3955 , A61P35/00 , A61K2039/505
Abstract: A substance which regulates immune-checkpoints for use as a medicament for treatment of a tumor of a patient wherein the administration pattern of the medicament comprises administering a therapeutically effective amount of the substance to the tumor, in one or more sessions, and implanting seeds (204) carrying radium-224 in the tumor for intra-tumoral alpha-emitter radiotherapy less than two weeks from administering the substance.
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公开(公告)号：US12070621B2
公开(公告)日：2024-08-27
申请号：US18094411
申请日：2023-01-09
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Itzhak Kelson , Yona Keisari , Amnon Gat , Robert Den , Ofer Magen , Vered Domankevich , Lior Arazi , Tomer Cooks , Guy Heger , Mirta Duman{hacek over (c)}ić , Ishai Luz , Maayan Hedva Vatarescu
IPC: A61N5/10
CPC classification number: A61N5/1007 , A61N5/1027 , A61N2005/1024 , A61N2005/1085
Abstract: A method for treating a tumor, comprising identifying a tumor as a pancreatic cancer tumor and implanting in the tumor identified as a pancreatic cancer tumor, at least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 5.6 Mega becquerel (MBq) hour and 11.6 MBq hour, per centimeter length.
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公开(公告)号：US11969485B2
公开(公告)日：2024-04-30
申请号：US16979543
申请日：2019-03-28
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Itzhak Kelson , Yona Keisari , Michael Schmidt , Amnon Gat , Ofer Magen , Guy Keret , Amitai Sosnovitch , Avia Berkowitz
CPC classification number: A61K51/1282 , A61N5/1001 , A61K9/0004 , A61K9/0009 , A61K9/0024
Abstract: A brachytherapy device including a base adapted for being at least partially introduced into a body of a subject and a plurality of radionuclide atoms of a first alpha-emitting isotope, coupled to the base in a manner that not more than 15% of the radionuclide atoms leave the base in 24 hours, in methods other than radioactive decay. When installed in a human subject, the brachytherapy device emits radionuclide atoms of the first alpha-emitting isotope at a rate of at least 0.1% of the number of radionuclide atoms of the first alpha-emitting isotope coupled to the base, per 24 hours.
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Patent Agency Ranking
公开(公告)号：US20230158329A1
公开(公告)日：2023-05-25
申请号：US18094419
申请日：2023-01-09
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Itzhak Kelson , Yona Keisari , Amnon Gat , Robert Den , Ofer Magen , Vered Domankevich , Lior Arazi , Tomer Cooks , Guy Heger , Mirta Dumancic , Ishai Luz , Maayan Hedva Vatarescu
IPC: A61N5/10
CPC classification number: A61N5/1007 , A61N5/1031 , A61N5/1071
Abstract: A method for treating a tumor, comprising identifying a tumor as a glioblastoma tumor and implanting in the tumor identified as a glioblastoma tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 6.5 Mega becquerel (MBq) hour and 14.3 MBq hour, per centimeter length.
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公开(公告)号：US20230142901A1
公开(公告)日：2023-05-11
申请号：US18094411
申请日：2023-01-09
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Itzhak Kelson , Yona Keisari , Amnon Gat , Robert Den , Ofer Magen , Vered Domankevich , Lior Arazi , Tomer Cooks , Guy Heger , Mirta Dumancic , Ishai Luz , Maayan Hedva Vatarescu
IPC: A61N5/10
CPC classification number: A61N5/1007
Abstract: A method for treating a tumor, comprising identifying a tumor as a pancreatic cancer tumor and implanting in the tumor identified as a pancreatic cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 5.6 Mega becquerel (MBq) hour and 11.6 MBq hour, per centimeter length.
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公开(公告)号：US20210128945A1
公开(公告)日：2021-05-06
申请号：US17092269
申请日：2020-11-08
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Michael Schmidt , Itzhak Kelson
Abstract: A method of accumulating radium radionuclides, comprising providing a first solution including thorium radionuclides and a thorium-binding extractant, wherein the first solution does not bind to radium, allowing a portion of the thorium radionuclides in the first solution to decay into radium atoms and collecting radium atoms resulting from the decay. The collected radium atoms may be included in a solution in which brachytherapy sources are dipped, in a manner which collects the radium atoms onto the source.
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公开(公告)号：US20240382779A1
公开(公告)日：2024-11-21
申请号：US18783445
申请日：2024-07-25
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Itzhak Kelson , Yona Keisari , Amnon Gat , Robert Den , Ofer Magen , Vered Domankevich , Lior Arazi , Tomer Cooks , Guy Heger , Mirta Dumancic , Ishai Luz , Maayan Hedva Vatarescu
IPC: A61N5/10
Abstract: A method for treating a tumor, comprising identifying a tumor as a colorectal cancer tumor and implanting in the tumor identified as a colorectal cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source with a suitable radon release rate and for a given duration, such that the source provides during the given duration a cumulated activity of released radon between 3.7 Mega becquerel (MBq) hour and 9.2 MBq hour, per centimeter length.
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公开(公告)号：US20240374920A1
公开(公告)日：2024-11-14
申请号：US18783450
申请日：2024-07-25
Applicant: ALPHA TAU MEDICAL LTD.
Inventor： Itzhak Kelson , Yona Keisari , Amnon Gat , Robert Den , Ofer Magen , Vered Domankevich , Lior Arazi , Tomer Cooks , Guy Heger , Mirta Dumancic , Ishai Luz , Maayan Hedva Vatarescu
IPC: A61N5/10
Abstract: A method for treating a tumor, comprising identifying a tumor as a pancreatic cancer tumor and implanting in the tumor identified as a pancreatic cancer tumor, as least one diffusing alpha-emitter radiation therapy (DaRT) source (21) with a suitable radon release rate and for a given duration, such that the source (21) provides during the given duration a cumulated activity of released radon between 5.6 Mega becquerel (MBq) hour and 11.6 MBq hour, per centimeter length.
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