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1.发明申请Method for Detecting Atmospheric Vapors at Parts per Quadrillion (PPQ) Concentrations 有权用于检测每四分之一部分（PPQ）浓度的大气蒸气的方法公开(公告)号：US20120325024A1
公开(公告)日：2012-12-27
申请号：US13532146
申请日：2012-06-25
申请人： Guillermo Vidal-de-Miguel , Daoiz Zamora , Mario Amo , Alejandro Casado , Gonzalo Fernandez de la Mora , Juan Fernandez de la Mora
发明人： Guillermo Vidal-de-Miguel , Daoiz Zamora , Mario Amo , Alejandro Casado , Gonzalo Fernandez de la Mora , Juan Fernandez de la Mora
IPC分类号： G01N1/22
CPC分类号： G01N27/622 , G01N33/0057 , H01J49/165
摘要： Improvements are provided in the detection of atmospheric vapors by ionizing them near ambient pressure, and analyzing them as ions. Lowest detection limits of parts per quadrillion (ppq) concentrations are enabled by a combination of improvements, including the use of a filter to remove occasional intense signal from explosive particles. Several sources of chemical background are identified and solutions for their reduction or elimination are presented. Gains in response time may be achieved by operating at elevated temperature. When the ionizer is an electrospray source, the use of high boiling point solvents is indicated. An increased selectivity is achieved by operating a differential mobility analyzer (DMA) in series with a mass spectrometer. However, ppq sensitivities require various improvements in the DMA system including a special coupling to the ionizer, controlling the temperature in the DMA pump circuit, avoidance of induction on the DMA electrodes from heating devices, etc.
摘要翻译： 通过在大气压附近电离大气蒸气并分析它们作为离子，提供了改进。 通过改进的组合实现了每千瓦（ppq）浓度的最低检测限，包括使用过滤器去除爆炸性颗粒的偶然强烈信号。 确定了化学背景的几个来源，并提出了其减少或消除的解决方案。 响应时间的增益可以通过在高温下运行来实现。 当电离器是电喷雾源时，指示使用高沸点溶剂。 通过与质谱仪串联操作差示迁移率分析仪（DMA）来实现增加的选择性。 然而，ppq灵敏度需要DMA系统的各种改进，包括与离子发生器的特殊耦合，控制DMA泵电路中的温度，避免加热装置上DMA电极的感应等。
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2.发明申请Method and apparatus to accurately discriminate gas phase ions with several filtering devices in tandem 有权用多个过滤装置串联精确地区分气相离子的方法和装置公开(公告)号：US20080203290A1
公开(公告)日：2008-08-28
申请号：US12070937
申请日：2008-02-23
IPC分类号： B01D59/44
CPC分类号： H01J49/4215 , G01N15/0266 , H01J49/004
摘要： A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
摘要翻译： 基于一个或多个差分迁移率分析仪（DMA）和可能还有质谱仪（MS）串联使用的方法，教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法， ，全部排列在一起。 两个DMA在离子阻力对漂移速度曲线（例如，线性对非线性区域）的不同区域中操作，因此根据离子的多于一个独立鉴别参数进行分离。 即使通过使用DMA选择窄范围的离子，并且在MS中分析它们，也可以通过单阶段质谱分离来实现非常高的辨别，首先没有碎裂，然后是碎裂。 当MS的入口区域发生碎裂时，该过程不一定需要串联MS。 对于大量目标物种，单离子监测模式（SIM）可以进行快速准确的鉴别，即使是相对便宜又轻的单一四极杆MS系统，其中串联的各种过滤器将打开适合通过的预配置窄窗口 的列表中的每个离子。
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公开(公告)号：US20150023035A1
公开(公告)日：2015-01-22
申请号：US13942735
申请日：2013-07-16
申请人： Gregory Wood , Alejandro Casado
发明人： Gregory Wood , Alejandro Casado
摘要： An automotive safety device, specifically, an automobile safety device that assists drivers to remain in their proper driving lane when driving a moving vehicle. One embodiment of the present invention can include a flat planar body member, a plurality of light emitting members connected to the planar body member, wherein the light emitting members are configured in a predetermined arrangement, a power source electronically connected to the light emitting members, and a selectively engageable dimmer switch electronically connected to the power source and the light emitting members. The plurality of light emitting members can be configured in an angled position such that when the planar body member is positioned on the dashboard of a motor vehicle, between a steering wheel and a windshield of the motor vehicle, the reflection of the light emitting members appears to project outwardly in a straight line in front of the windshield.
摘要翻译： 一种汽车安全装置，特别是一种汽车安全装置，用于在驾驶移动车辆时协助驾驶员保持在适当的行车道。 本发明的一个实施例可以包括平坦平面本体构件，连接到平面本体构件的多个发光构件，其中发光构件以预定布置配置，电连接到发光构件的电源， 以及电连接到电源和发光构件的可选择性地接合的调光开关。 多个发光构件可以被构造成成角度的位置，使得当平面主体构件位于机动车辆的仪表板上时，在方向盘和机动车辆的挡风玻璃之间，发光构件的反射出现 在挡风玻璃前面的直线向外突出。
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4.发明授权Method and apparatus to accurately discriminate gas phase ions with several filtering devices in tandem 有权用多个过滤装置串联精确地区分气相离子的方法和装置公开(公告)号：US08278622B2
公开(公告)日：2012-10-02
申请号：US12946435
申请日：2010-11-15
IPC分类号： G01N15/00
CPC分类号： H01J49/4215 , G01N15/0266 , H01J49/004
摘要： A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
摘要翻译： 基于一个或多个差分迁移率分析仪（DMA）和可能还有质谱仪（MS）串联使用的方法，教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法， ，全部排列在一起。 两个DMA在离子阻力对漂移速度曲线（例如，线性对非线性区域）的不同区域中操作，因此根据离子的多于一个独立鉴别参数进行分离。 即使通过使用DMA选择窄范围的离子，并且在MS中分析它们，也可以通过单阶段质谱分离来实现非常高的辨别，首先没有碎裂，然后是碎裂。 当MS的入口区域发生碎裂时，该过程不一定需要串联MS。 即使使用相对便宜又轻的单一四极杆MS系统，单个离子监测模式（SIM）对于大量目标物种可以进行快速准确的鉴别，其中各种过滤器串联放置可以打开预先配置的适合通过的窄窗口 的列表中的每个离子。
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5.发明授权Method and apparatus to accurately discriminate gas phase ions with several filtering devices in tandem 有权用多个过滤装置串联精确地区分气相离子的方法和装置公开(公告)号：US07855360B2
公开(公告)日：2010-12-21
申请号：US12070937
申请日：2008-02-23
IPC分类号： G01N15/00
CPC分类号： H01J49/4215 , G01N15/0266 , H01J49/004
摘要： A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
摘要翻译： 基于一个或多个差分迁移率分析仪（DMA）和可能还有质谱仪（MS）串联使用的方法，教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法， ，全部排列在一起。 两个DMA在离子阻力对漂移速度曲线（例如，线性对非线性区域）的不同区域中操作，因此根据离子的多于一个独立鉴别参数进行分离。 即使通过使用DMA选择窄范围的离子，并且在MS中分析它们，也可以通过单阶段质谱分离来实现非常高的辨别，首先没有碎裂，然后是碎裂。 当MS的入口区域发生碎裂时，该过程不一定需要串联MS。 对于大量目标物种，单离子监测模式（SIM）可以进行快速准确的鉴别，即使是相对便宜又轻的单一四极杆MS系统，其中串联的各种过滤器将打开适合通过的预配置窄窗口 的列表中的每个离子。
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6.发明授权Method for detecting atmospheric vapors at parts per quadrillion (PPQ) concentrations 有权用于检测每千瓦（PPQ）浓度的大气蒸气的方法公开(公告)号：US09297785B2
公开(公告)日：2016-03-29
申请号：US13532146
申请日：2012-06-25
申请人： Mario Amo , Daoiz Zamora , Alejandro Casado , Gonzalo Fernandez de la Mora , Guillermo Vidal-de-Miguel , Juan Fernandez de la Mora
发明人： Mario Amo , Daoiz Zamora , Alejandro Casado , Gonzalo Fernandez de la Mora , Guillermo Vidal-de-Miguel , Juan Fernandez de la Mora
CPC分类号： G01N27/622 , G01N33/0057 , H01J49/165
摘要： Improvements are provided in the detection of atmospheric vapors by ionizing them near ambient pressure, and analyzing them as ions. Lowest detection limits of parts per quadrillion (ppq) concentrations are enabled by a combination of improvements, including the use of a filter to remove occasional intense signal from explosive particles. Several sources of chemical background are identified and solutions for their reduction or elimination are presented. Gains in response time may be achieved by operating at elevated temperature. When the ionizer is an electrospray source, the use of high boiling point solvents is indicated. An increased selectivity is achieved by operating a differential mobility analyzer (DMA) in series with a mass spectrometer. However, ppq sensitivities require various improvements in the DMA system including a special coupling to the ionizer, controlling the temperature in the DMA pump circuit, avoidance of induction on the DMA electrodes from heating devices, etc.
摘要翻译： 通过在大气压附近电离大气蒸气并分析它们作为离子，提供了改进。 通过改进的组合实现了每千瓦（ppq）浓度的最低检测限，包括使用过滤器去除爆炸性颗粒的偶然强烈信号。 确定了化学背景的几个来源，并提出了其减少或消除的解决方案。 响应时间的增益可以通过在高温下运行来实现。 当电离器是电喷雾源时，指示使用高沸点溶剂。 通过与质谱仪串联操作差示迁移率分析仪（DMA）来实现增加的选择性。 然而，ppq灵敏度需要DMA系统的各种改进，包括与离子发生器的特殊耦合，控制DMA泵电路中的温度，避免加热装置上DMA电极的感应等。
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公开(公告)号：US09187036B2
公开(公告)日：2015-11-17
申请号：US13942735
申请日：2013-07-16
申请人： Gregory Wood , Alejandro Casado
发明人： Gregory Wood , Alejandro Casado
摘要： An automotive safety device, specifically, an automobile safety device that assists drivers to remain in their proper driving lane when driving a moving vehicle. One embodiment of the present invention can include a flat planar body member, a plurality of light emitting members connected to the planar body member, wherein the light emitting members are configured in a predetermined arrangement, a power source electronically connected to the light emitting members, and a selectively engageable dimmer switch electronically connected to the power source and the light emitting members. The plurality of light emitting members can be configured in an angled position such that when the planar body member is positioned on the dashboard of a motor vehicle, between a steering wheel and a windshield of the motor vehicle, the reflection of the light emitting members appears to project outwardly in a straight line in front of the windshield.
摘要翻译： 一种汽车安全装置，特别是一种汽车安全装置，用于在驾驶移动车辆时协助驾驶员保持在正确的行车道。 本发明的一个实施例可以包括平坦平面本体构件，连接到平面本体构件的多个发光构件，其中发光构件以预定布置配置，电连接到发光构件的电源， 以及电连接到电源和发光构件的可选择性地接合的调光开关。 多个发光构件可以被构造成成角度的位置，使得当平面主体构件位于机动车辆的仪表板上时，在方向盘和机动车辆的挡风玻璃之间，发光构件的反射出现 在挡风玻璃前面的直线向外突出。
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8.发明申请METHOD AND APPARATUS TO ACCURATELY DISCRIMINATE GAS PHASE IONS WITH SEVERAL FILTERING DEVICES IN TANDEM 有权在TANDEM中精确地分离气相相关离子的方法和装置，具有多个过滤装置公开(公告)号：US20110057096A1
公开(公告)日：2011-03-10
申请号：US12946435
申请日：2010-11-15
IPC分类号： H01J49/00
CPC分类号： H01J49/4215 , G01N15/0266 , H01J49/004
摘要： A method for fast and accurate recognition of species contained in trace amounts in complex mixtures such as ambient air or biological fluids is taught based on the use in tandem of one or several differential mobility analyzers (DMAs) and possibly also a mass spectrometer (MS), all arranged in series. The two DMAs operate in different regions of the ion drag versus drift velocity curve (for instance, linear versus nonlinear regions), hence separating according to more than one independently discriminating parameters of the ion. Very high discrimination can be achieved even with a single stage of mass spectrometric separation by selecting a narrow range of ions with the DMA, and analyzing them in the MS, first without fragmentation, and then with fragmentation. This process does not require necessarily a tandem MS when fragmentation takes place in the inlet region of the MS. Fast and accurate discrimination is possible in single ion monitoring mode (SIM) for a large number of targeted species, even with relatively inexpensive and light single quadrupole MS systems, where the various filters placed in series would open pre-configured narrow windows suitable for passage of each ion in a list.
摘要翻译： 基于一个或多个差分迁移率分析仪（DMA）和可能还有质谱仪（MS）串联使用的方法，教导了在复杂混合物如环境空气或生物流体中快速和准确地识别微量物质的方法， ，全部排列在一起。 两个DMA在离子阻力对漂移速度曲线（例如，线性对非线性区域）的不同区域中操作，因此根据离子的多于一个独立鉴别参数进行分离。 即使通过使用DMA选择窄范围的离子，并且在MS中分析它们，也可以通过单阶段质谱分离来实现非常高的辨别，首先没有碎裂，然后是碎裂。 当MS的入口区域发生碎裂时，该过程不一定需要串联MS。 即使使用相对便宜又轻的单一四极杆MS系统，单个离子监测模式（SIM）对于大量目标物种可以进行快速准确的鉴别，其中各种过滤器串联放置可以打开预先配置的适合通过的窄窗口 的列表中的每个离子。
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